{
    "info": {
        "nct_id": "NCT06755866",
        "official_title": "DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer",
        "inclusion_criteria": "1. Be 18 years of age and older;\n2. First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy;\n3. The clinical stage is cT1b~cT2N+; or the clinical stage is cT3~cT4 any N, (thoracic esophageal cancer, esophagogastric junction cancer);\n4. There are no contraindications to MRI examination\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "1. Have other primary tumors;\n2. The image quality does not meet the diagnostic criteria;\n3. Those who do not cooperate with the inspection;\n4. Patients who have received prior chemoradiotherapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Be 18 years of age and older;",
            "criterions": [
                {
                    "exact_snippets": "18 years of age and older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. First diagnosis of esophageal squamous cell carcinoma confirmed by histopathological biopsy;",
            "criterions": [
                {
                    "exact_snippets": "First diagnosis of esophageal squamous cell carcinoma",
                    "criterion": "esophageal squamous cell carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": "first"
                        }
                    ]
                },
                {
                    "exact_snippets": "confirmed by histopathological biopsy",
                    "criterion": "histopathological biopsy",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. The clinical stage is cT1b~cT2N+; or the clinical stage is cT3~cT4 any N, (thoracic esophageal cancer, esophagogastric junction cancer);",
            "criterions": [
                {
                    "exact_snippets": "clinical stage is cT1b~cT2N+",
                    "criterion": "clinical stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "cT1b",
                                "cT2N+"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "clinical stage is cT3~cT4 any N",
                    "criterion": "clinical stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "cT3",
                                "cT4 any N"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "thoracic esophageal cancer",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "esophagogastric junction cancer",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. There are no contraindications to MRI examination",
            "criterions": [
                {
                    "exact_snippets": "no contraindications to MRI examination",
                    "criterion": "contraindications to MRI examination",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Have other primary tumors;",
            "criterions": [
                {
                    "exact_snippets": "Have other primary tumors",
                    "criterion": "primary tumors",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. The image quality does not meet the diagnostic criteria;",
            "criterions": [
                {
                    "exact_snippets": "image quality does not meet the diagnostic criteria",
                    "criterion": "image quality",
                    "requirements": [
                        {
                            "requirement_type": "diagnostic criteria",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Those who do not cooperate with the inspection;",
            "criterions": [
                {
                    "exact_snippets": "do not cooperate with the inspection",
                    "criterion": "cooperation with inspection",
                    "requirements": [
                        {
                            "requirement_type": "cooperation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Patients who have received prior chemoradiotherapy",
            "criterions": [
                {
                    "exact_snippets": "Patients who have received prior chemoradiotherapy",
                    "criterion": "prior chemoradiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}