{
    "info": {
        "nct_id": "NCT06672120",
        "official_title": "Exercise in Regional Breast Cancer With Neoadjuvant Anthracycline- Based Chemotherapy and Immunotherapy With Checkpoint-Inhibition",
        "inclusion_criteria": "* Female patients with newly diagnosed, local triple-negative breast cancer (stage I-III) ≥ 18 to 50 years of age scheduled for immunochemotherapy with pembrolizumab and anthracycline-based chemotherapy\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 50 Years",
        "exclusion_criteria": "* Unstable cardiac condition (clinical suspicion of progress or unstable coronary artery disease, signs of acute heart failure, haemodynamically relevant arrhythmias)\n* Orthopaedic disability to exercise",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Female patients with newly diagnosed, local triple-negative breast cancer (stage I-III) ≥ 18 to 50 years of age scheduled for immunochemotherapy with pembrolizumab and anthracycline-based chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "Female patients",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    ]
                },
                {
                    "exact_snippets": "newly diagnosed, local triple-negative breast cancer",
                    "criterion": "breast cancer type",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": "newly diagnosed"
                        },
                        {
                            "requirement_type": "locality",
                            "expected_value": "local"
                        },
                        {
                            "requirement_type": "subtype",
                            "expected_value": "triple-negative"
                        }
                    ]
                },
                {
                    "exact_snippets": "stage I-III",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "≥ 18 to 50 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 50,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "scheduled for immunochemotherapy with pembrolizumab and anthracycline-based chemotherapy",
                    "criterion": "treatment plan",
                    "requirements": [
                        {
                            "requirement_type": "scheduled",
                            "expected_value": [
                                "immunochemotherapy with pembrolizumab",
                                "anthracycline-based chemotherapy"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 50 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 50 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 50,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Unstable cardiac condition (clinical suspicion of progress or unstable coronary artery disease, signs of acute heart failure, haemodynamically relevant arrhythmias)",
            "criterions": [
                {
                    "exact_snippets": "Unstable cardiac condition (clinical suspicion of progress or unstable coronary artery disease",
                    "criterion": "unstable coronary artery disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Unstable cardiac condition ... signs of acute heart failure",
                    "criterion": "acute heart failure",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Unstable cardiac condition ... haemodynamically relevant arrhythmias",
                    "criterion": "haemodynamically relevant arrhythmias",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Orthopaedic disability to exercise",
            "criterions": [
                {
                    "exact_snippets": "Orthopaedic disability to exercise",
                    "criterion": "orthopaedic disability",
                    "requirements": [
                        {
                            "requirement_type": "impact on exercise",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}