{
    "info": {
        "nct_id": "NCT06479473",
        "official_title": "Chemoimmunotherapy Followed by All-residual-lesions Radiotherapy for Extensive-stage Small-cell Lung Cancer: A Phase I/II Trial",
        "inclusion_criteria": "* 18-70 years old;\n* ECOG 0-1;\n* Adequate organ function to tolerate chemotherapy, immunotherapy and radiotherapy;\n* Small-cell lung cancer;\n* Extensive stage confirmed by cranial MRI, chest CT, abdominal ultrasonograph, bone scan or cranial MRI and PET-CT;\n* Signature of inform consent.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "Younger than 18 years old or older than 70 years old;\n\n* ECOG>1;\n* Inadequate organ function to tolerate chemotherapy, immunotherapy and radiotherapy;\n* Non-small cell lung cancer and other neuroendocrine carcinoma including typical or atypical carcinoid, large-cell neuroendocrine carcinoma;\n* Limited stage confirmed by cranial MRI, chest CT, abdominal ultrasonograph, bone scan or cranial MRI and PET-CT;\n* No signature of inform consent.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* 18-70 years old;",
            "criterions": [
                {
                    "exact_snippets": "18-70 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG 0-1;",
            "criterions": [
                {
                    "exact_snippets": "ECOG 0-1",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate organ function to tolerate chemotherapy, immunotherapy and radiotherapy;",
            "criterions": [
                {
                    "exact_snippets": "Adequate organ function to tolerate chemotherapy",
                    "criterion": "organ function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "tolerance",
                            "expected_value": "chemotherapy"
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate organ function to tolerate ... immunotherapy",
                    "criterion": "organ function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "tolerance",
                            "expected_value": "immunotherapy"
                        }
                    ]
                },
                {
                    "exact_snippets": "Adequate organ function to tolerate ... radiotherapy",
                    "criterion": "organ function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "tolerance",
                            "expected_value": "radiotherapy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Small-cell lung cancer;",
            "criterions": [
                {
                    "exact_snippets": "Small-cell lung cancer",
                    "criterion": "small-cell lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Extensive stage confirmed by cranial MRI, chest CT, abdominal ultrasonograph, bone scan or cranial MRI and PET-CT;",
            "criterions": [
                {
                    "exact_snippets": "Extensive stage confirmed by cranial MRI, chest CT, abdominal ultrasonograph, bone scan or cranial MRI and PET-CT",
                    "criterion": "extensive stage",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "cranial MRI",
                                "chest CT",
                                "abdominal ultrasonograph",
                                "bone scan",
                                "PET-CT"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Signature of inform consent.",
            "criterions": [
                {
                    "exact_snippets": "Signature of inform consent.",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signature",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "Younger than 18 years old or older than 70 years old;",
            "criterions": [
                {
                    "exact_snippets": "Younger than 18 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "older than 70 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inadequate organ function to tolerate chemotherapy, immunotherapy and radiotherapy;",
            "criterions": [
                {
                    "exact_snippets": "Inadequate organ function to tolerate chemotherapy, immunotherapy and radiotherapy",
                    "criterion": "organ function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Non-small cell lung cancer and other neuroendocrine carcinoma including typical or atypical carcinoid, large-cell neuroendocrine carcinoma;",
            "criterions": [
                {
                    "exact_snippets": "Non-small cell lung cancer",
                    "criterion": "non-small cell lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other neuroendocrine carcinoma including typical or atypical carcinoid, large-cell neuroendocrine carcinoma",
                    "criterion": "neuroendocrine carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Limited stage confirmed by cranial MRI, chest CT, abdominal ultrasonograph, bone scan or cranial MRI and PET-CT;",
            "criterions": [
                {
                    "exact_snippets": "Limited stage confirmed by cranial MRI, chest CT, abdominal ultrasonograph, bone scan or cranial MRI and PET-CT",
                    "criterion": "limited stage",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": [
                                "cranial MRI",
                                "chest CT",
                                "abdominal ultrasonograph",
                                "bone scan",
                                "PET-CT"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No signature of inform consent.",
            "criterions": [
                {
                    "exact_snippets": "No signature of inform consent.",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signature",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* ECOG&gt;1;",
            "criterions": [
                {
                    "exact_snippets": "ECOG>1",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "performance status",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}