{
    "info": {
        "nct_id": "NCT06353191",
        "official_title": "Biomarkers to Predict Cancer Therapy-Related Cardiotoxicity",
        "inclusion_criteria": "* 18 years of age or older\n* Treated for any malignancy with any type of chemotherapy including oral, parenteral therapy and immunotherapy\n* One of the following:\n\n  * Diagnosed with cardiotoxicity defined as; cardiomyopathy, symptomatic heart failure, asymptomatic reduced systolic function, acute coronary syndrome, myocardial infarction, critical limb ischemia, cardiac arrhythmias or myocarditis possibly related to prior cancer treatment\n  * Completed chemotherapy with no cardiotoxicity at least two years post treatment\n  * Patients with cancer who will be initiating systemic therapy with potentially cardiotoxic medications. This will include chemotherapy, immunotherapy, targeted therapy that have been associated with cardiac toxicity\n* An understanding of the protocol and its requirements, risks, and discomforts\n* The ability and willingness to sign an informed consent\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "- Inability on the part of the patient to understand the informed consent or be compliant with the protocol",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* 18 years of age or older",
            "criterions": [
                {
                    "exact_snippets": "18 years of age or older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Treated for any malignancy with any type of chemotherapy including oral, parenteral therapy and immunotherapy",
            "criterions": [
                {
                    "exact_snippets": "Treated for any malignancy with any type of chemotherapy including oral, parenteral therapy and immunotherapy",
                    "criterion": "treatment for malignancy",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "chemotherapy",
                                "oral",
                                "parenteral therapy",
                                "immunotherapy"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Diagnosed with cardiotoxicity defined as; cardiomyopathy, symptomatic heart failure, asymptomatic reduced systolic function, acute coronary syndrome, myocardial infarction, critical limb ischemia, cardiac arrhythmias or myocarditis possibly related to prior cancer treatment",
            "criterions": [
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; cardiomyopathy",
                    "criterion": "cardiomyopathy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... symptomatic heart failure",
                    "criterion": "symptomatic heart failure",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... asymptomatic reduced systolic function",
                    "criterion": "asymptomatic reduced systolic function",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... acute coronary syndrome",
                    "criterion": "acute coronary syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... myocardial infarction",
                    "criterion": "myocardial infarction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... critical limb ischemia",
                    "criterion": "critical limb ischemia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... cardiac arrhythmias",
                    "criterion": "cardiac arrhythmias",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosed with cardiotoxicity defined as; ... myocarditis possibly related to prior cancer treatment",
                    "criterion": "myocarditis possibly related to prior cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Completed chemotherapy with no cardiotoxicity at least two years post treatment",
            "criterions": [
                {
                    "exact_snippets": "Completed chemotherapy",
                    "criterion": "chemotherapy completion",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "no cardiotoxicity",
                    "criterion": "cardiotoxicity",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "at least two years post treatment",
                    "criterion": "time since treatment",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with cancer who will be initiating systemic therapy with potentially cardiotoxic medications. This will include chemotherapy, immunotherapy, targeted therapy that have been associated with cardiac toxicity",
            "criterions": [
                {
                    "exact_snippets": "Patients with cancer",
                    "criterion": "cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "initiating systemic therapy",
                    "criterion": "systemic therapy",
                    "requirements": [
                        {
                            "requirement_type": "initiation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "potentially cardiotoxic medications",
                    "criterion": "cardiotoxic medications",
                    "requirements": [
                        {
                            "requirement_type": "potential cardiotoxicity",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "association with cardiac toxicity",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "immunotherapy",
                    "criterion": "immunotherapy",
                    "requirements": [
                        {
                            "requirement_type": "association with cardiac toxicity",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "targeted therapy",
                    "criterion": "targeted therapy",
                    "requirements": [
                        {
                            "requirement_type": "association with cardiac toxicity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* An understanding of the protocol and its requirements, risks, and discomforts",
            "criterions": [
                {
                    "exact_snippets": "An understanding of the protocol and its requirements, risks, and discomforts",
                    "criterion": "understanding of the protocol",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* The ability and willingness to sign an informed consent",
            "criterions": [
                {
                    "exact_snippets": "The ability ... to sign an informed consent",
                    "criterion": "ability to sign informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willingness to sign an informed consent",
                    "criterion": "willingness to sign informed consent",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "- Inability on the part of the patient to understand the informed consent or be compliant with the protocol",
            "criterions": [
                {
                    "exact_snippets": "Inability on the part of the patient to understand the informed consent",
                    "criterion": "understanding of informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Inability on the part of the patient to ... be compliant with the protocol",
                    "criterion": "compliance with the protocol",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* One of the following:",
            "criterions": []
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}