{
    "info": {
        "nct_id": "NCT06164691",
        "official_title": "The Effect of Peri-surgery Blue and Amber Light Exposure in Subjects Undergoing Medical and Surgical Treatment of Cancer",
        "inclusion_criteria": "1. greater than 18 and less than 80 years of age\n2. adenocarcinoma of the pancreas (unresectable) or adenocarcinoma of the rectum (stage II or III).\nHealthy volunteers allowed\nMust have minimum age of 19 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "1. Prior chemotherapy (inability to determine the integrity of the immune response)\n2. Autoimmune disorder, immunosuppression therapy, or immunocompromised state (inability to determine the integrity of the immune response)\n3. Blindness or other significant vision disorder or prior traumatic brain injury (the inability to determine the integrity of functional optic and suprachiasmatic pathways)\n4. Hematological disease - e.g., myelodysplastic syndrome, leukemia (inability to determine the integrity of the immune response)\n5. Bipolar disorder or schizophrenia (potential heightened symptoms)\n6. Refusal/ineligible to undergo neoadjuvant chemotherapy and/or radiation",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. greater than 18 and less than 80 years of age",
            "criterions": [
                {
                    "exact_snippets": "greater than 18 and less than 80 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. adenocarcinoma of the pancreas (unresectable) or adenocarcinoma of the rectum (stage II or III).",
            "criterions": [
                {
                    "exact_snippets": "adenocarcinoma of the pancreas (unresectable)",
                    "criterion": "adenocarcinoma of the pancreas",
                    "requirements": [
                        {
                            "requirement_type": "resectability",
                            "expected_value": "unresectable"
                        }
                    ]
                },
                {
                    "exact_snippets": "adenocarcinoma of the rectum (stage II or III)",
                    "criterion": "adenocarcinoma of the rectum",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "II",
                                "III"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 19 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 19 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 19,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Prior chemotherapy (inability to determine the integrity of the immune response)",
            "criterions": [
                {
                    "exact_snippets": "Prior chemotherapy",
                    "criterion": "prior chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Autoimmune disorder, immunosuppression therapy, or immunocompromised state (inability to determine the integrity of the immune response)",
            "criterions": [
                {
                    "exact_snippets": "Autoimmune disorder",
                    "criterion": "autoimmune disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "immunosuppression therapy",
                    "criterion": "immunosuppression therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "immunocompromised state (inability to determine the integrity of the immune response)",
                    "criterion": "immunocompromised state",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Blindness or other significant vision disorder or prior traumatic brain injury (the inability to determine the integrity of functional optic and suprachiasmatic pathways)",
            "criterions": [
                {
                    "exact_snippets": "Blindness or other significant vision disorder",
                    "criterion": "vision disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "prior traumatic brain injury",
                    "criterion": "traumatic brain injury",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Hematological disease - e.g., myelodysplastic syndrome, leukemia (inability to determine the integrity of the immune response)",
            "criterions": [
                {
                    "exact_snippets": "Hematological disease - e.g., myelodysplastic syndrome, leukemia",
                    "criterion": "hematological disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "inability to determine the integrity of the immune response",
                    "criterion": "integrity of the immune response",
                    "requirements": [
                        {
                            "requirement_type": "determinability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Bipolar disorder or schizophrenia (potential heightened symptoms)",
            "criterions": [
                {
                    "exact_snippets": "Bipolar disorder",
                    "criterion": "bipolar disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "schizophrenia",
                    "criterion": "schizophrenia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Refusal/ineligible to undergo neoadjuvant chemotherapy and/or radiation",
            "criterions": [
                {
                    "exact_snippets": "Refusal/ineligible to undergo neoadjuvant chemotherapy",
                    "criterion": "neoadjuvant chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Refusal/ineligible to undergo ... radiation",
                    "criterion": "radiation",
                    "requirements": [
                        {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}