{
    "info": {
        "nct_id": "NCT06142760",
        "official_title": "Daily AI-based Treatment Adaptation Under Weekly Offline MR-guidance in Chemoradiotherapy for Cervical Cancer 1 AIM-C1",
        "inclusion_criteria": "* biopsy-proven cervical cancer including squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma\n* FIGO stage IB, IIA, IIB, IIIA, IIIB, IIIC1\n* indication and eligibility for definitive chemoradiotherapy including brachytherapy discussed in an interdisciplinary tumor board\n* Karnofsky performance score ≥ 70%\n* 18-80 years of age\n* Capacity of the patient to consent to participation in the study\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* FIGO stage IIIC2 and IV\n* Paraaortic lymphatic node metastases\n* small cell neuroendocrine cancer, melanoma and other rare cancers of the cervix\n* previous radiotherapy of the pelvic region\n* previous total or partial hysterectomy\n* neoadjuvant chemotherapy\n* contraindications against performing contrast-enhanced MRI scans (pacemakers, other implants making MRI impossible, allergy to gadolinium (GD)-based contrast agent)\n* claustrophobia\n* pregnant or lactating women\n* other primary malignancies within 5 years before except carcinoma in situ of the cervix and basal cell carcinoma of the skin\n* patient is enrolled in another study, that could influence the outcome of the presented study",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* biopsy-proven cervical cancer including squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma",
            "criterions": [
                {
                    "exact_snippets": "biopsy-proven cervical cancer",
                    "criterion": "cervical cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis method",
                            "expected_value": "biopsy-proven"
                        }
                    ]
                },
                {
                    "exact_snippets": "squamous-cell carcinoma",
                    "criterion": "cervical cancer subtype",
                    "requirements": [
                        {
                            "requirement_type": "subtype",
                            "expected_value": "squamous-cell carcinoma"
                        }
                    ]
                },
                {
                    "exact_snippets": "adenocarcinoma",
                    "criterion": "cervical cancer subtype",
                    "requirements": [
                        {
                            "requirement_type": "subtype",
                            "expected_value": "adenocarcinoma"
                        }
                    ]
                },
                {
                    "exact_snippets": "adeno-squamous cell carcinoma",
                    "criterion": "cervical cancer subtype",
                    "requirements": [
                        {
                            "requirement_type": "subtype",
                            "expected_value": "adeno-squamous cell carcinoma"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* FIGO stage IB, IIA, IIB, IIIA, IIIB, IIIC1",
            "criterions": [
                {
                    "exact_snippets": "FIGO stage IB, IIA, IIB, IIIA, IIIB, IIIC1",
                    "criterion": "FIGO stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IB",
                                "IIA",
                                "IIB",
                                "IIIA",
                                "IIIB",
                                "IIIC1"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* indication and eligibility for definitive chemoradiotherapy including brachytherapy discussed in an interdisciplinary tumor board",
            "criterions": [
                {
                    "exact_snippets": "indication and eligibility for definitive chemoradiotherapy including brachytherapy",
                    "criterion": "indication and eligibility for definitive chemoradiotherapy including brachytherapy",
                    "requirements": [
                        {
                            "requirement_type": "discussion",
                            "expected_value": "interdisciplinary tumor board"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Karnofsky performance score ≥ 70%",
            "criterions": [
                {
                    "exact_snippets": "Karnofsky performance score ≥ 70%",
                    "criterion": "Karnofsky performance score",
                    "requirements": [
                        {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 70,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* 18-80 years of age",
            "criterions": [
                {
                    "exact_snippets": "18-80 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Capacity of the patient to consent to participation in the study",
            "criterions": [
                {
                    "exact_snippets": "Capacity of the patient to consent",
                    "criterion": "capacity to consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* FIGO stage IIIC2 and IV",
            "criterions": [
                {
                    "exact_snippets": "FIGO stage IIIC2",
                    "criterion": "FIGO stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IIIC2"
                        }
                    ]
                },
                {
                    "exact_snippets": "FIGO stage ... IV",
                    "criterion": "FIGO stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Paraaortic lymphatic node metastases",
            "criterions": [
                {
                    "exact_snippets": "Paraaortic lymphatic node metastases",
                    "criterion": "paraaortic lymphatic node metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* small cell neuroendocrine cancer, melanoma and other rare cancers of the cervix",
            "criterions": [
                {
                    "exact_snippets": "small cell neuroendocrine cancer",
                    "criterion": "small cell neuroendocrine cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "melanoma",
                    "criterion": "melanoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other rare cancers of the cervix",
                    "criterion": "rare cancers of the cervix",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* previous radiotherapy of the pelvic region",
            "criterions": [
                {
                    "exact_snippets": "previous radiotherapy of the pelvic region",
                    "criterion": "radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "pelvic region"
                        },
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* previous total or partial hysterectomy",
            "criterions": [
                {
                    "exact_snippets": "previous total or partial hysterectomy",
                    "criterion": "hysterectomy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "total",
                                "partial"
                            ]
                        },
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* neoadjuvant chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "neoadjuvant chemotherapy",
                    "criterion": "neoadjuvant chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* contraindications against performing contrast-enhanced MRI scans (pacemakers, other implants making MRI impossible, allergy to gadolinium (GD)-based contrast agent)",
            "criterions": [
                {
                    "exact_snippets": "contraindications against performing contrast-enhanced MRI scans (pacemakers, other implants making MRI impossible",
                    "criterion": "contraindications for MRI",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "allergy to gadolinium (GD)-based contrast agent",
                    "criterion": "allergy to gadolinium-based contrast agent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* claustrophobia",
            "criterions": [
                {
                    "exact_snippets": "claustrophobia",
                    "criterion": "claustrophobia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* pregnant or lactating women",
            "criterions": [
                {
                    "exact_snippets": "pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating women",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* other primary malignancies within 5 years before except carcinoma in situ of the cervix and basal cell carcinoma of the skin",
            "criterions": [
                {
                    "exact_snippets": "other primary malignancies within 5 years before",
                    "criterion": "other primary malignancies",
                    "requirements": [
                        {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "except carcinoma in situ of the cervix",
                    "criterion": "carcinoma in situ of the cervix",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "except ... basal cell carcinoma of the skin",
                    "criterion": "basal cell carcinoma of the skin",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* patient is enrolled in another study, that could influence the outcome of the presented study",
            "criterions": [
                {
                    "exact_snippets": "patient is enrolled in another study",
                    "criterion": "enrollment in another study",
                    "requirements": [
                        {
                            "requirement_type": "influence on outcome",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}