{
    "info": {
        "nct_id": "NCT05763472",
        "official_title": "Molecular Landscape Involved in the Onset of Breast Cancer in Patients With Germline BRCA-1/2 Mutations, During or After Therapy With Platinum-based Agents and/or PARP-inhibitors for Ovarian Cancer",
        "inclusion_criteria": "* Written informed consent.\n* Age older than 18 years.\n* Germline BRCA1/2 mutation.\n* Histologically confirmed ovarian cancer treated with platinum-based chemotherapy and/or PARP inhibitors.\n* Histologically confirmed breast cancer occurred during or after therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer.\n* Availability of FFPE breast and ovarian tumor samples.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Other malignancies in the last 2 years.\n* Prior chemotherapy or radiation therapy for other malignancies.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Written informed consent.",
            "criterions": [
                {
                    "exact_snippets": "Written informed consent.",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age older than 18 years.",
            "criterions": [
                {
                    "exact_snippets": "Age older than 18 years.",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Germline BRCA1/2 mutation.",
            "criterions": [
                {
                    "exact_snippets": "Germline BRCA1/2 mutation",
                    "criterion": "germline BRCA1/2 mutation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Histologically confirmed ovarian cancer treated with platinum-based chemotherapy and/or PARP inhibitors.",
            "criterions": [
                {
                    "exact_snippets": "Histologically confirmed ovarian cancer",
                    "criterion": "ovarian cancer",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    ]
                },
                {
                    "exact_snippets": "treated with platinum-based chemotherapy",
                    "criterion": "treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": "platinum-based chemotherapy"
                        }
                    ]
                },
                {
                    "exact_snippets": "treated with ... PARP inhibitors",
                    "criterion": "treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": "PARP inhibitors"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Histologically confirmed breast cancer occurred during or after therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer.",
            "criterions": [
                {
                    "exact_snippets": "Histologically confirmed breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    ]
                },
                {
                    "exact_snippets": "occurred during or after therapy with platinum-based agents",
                    "criterion": "therapy with platinum-based agents",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "during or after"
                        }
                    ]
                },
                {
                    "exact_snippets": "occurred during or after therapy with ... PARP-inhibitors",
                    "criterion": "therapy with PARP-inhibitors",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "during or after"
                        }
                    ]
                },
                {
                    "exact_snippets": "therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer",
                    "criterion": "ovarian cancer",
                    "requirements": [
                        {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "platinum-based agents",
                                "PARP-inhibitors"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Availability of FFPE breast and ovarian tumor samples.",
            "criterions": [
                {
                    "exact_snippets": "Availability of FFPE breast and ovarian tumor samples.",
                    "criterion": "FFPE breast tumor samples",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Availability of FFPE breast and ovarian tumor samples.",
                    "criterion": "FFPE ovarian tumor samples",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Other malignancies in the last 2 years.",
            "criterions": [
                {
                    "exact_snippets": "Other malignancies in the last 2 years.",
                    "criterion": "other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior chemotherapy or radiation therapy for other malignancies.",
            "criterions": [
                {
                    "exact_snippets": "Prior chemotherapy ... for other malignancies.",
                    "criterion": "prior chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Prior ... radiation therapy for other malignancies.",
                    "criterion": "prior radiation therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}