{
    "info": {
        "nct_id": "NCT05498194",
        "official_title": "Computational Prediction and Experimental Validation of Gastric Cancer Associated Neoantigens",
        "inclusion_criteria": "1. Male or Female patients aged 15 years and older\n2. Diagnosed with advanced gastric cancer (T2-4b/N0-3/M0-1 stage, according to the eighth edition of the American Joint Committee on Cancer TNM (AJCC TNM) system)\n3. Treatment-Naive\n4. Not known for other concomitant cancers\n5. Provide written informed consent\nMust have minimum age of 15 Years\nMust have maximum age of 18 Years",
        "exclusion_criteria": "1. Insufficient tumor tissues (less than 1 cm3)\n2. Unable to sign informed consent\n3. Underwent treatment",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Male or Female patients aged 15 years and older",
            "criterions": [
                {
                    "exact_snippets": "Male or Female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "allowed_values",
                            "expected_value": [
                                "Male",
                                "Female"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "aged 15 years and older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum_age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 15,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Diagnosed with advanced gastric cancer (T2-4b/N0-3/M0-1 stage, according to the eighth edition of the American Joint Committee on Cancer TNM (AJCC TNM) system)",
            "criterions": [
                {
                    "exact_snippets": "Diagnosed with advanced gastric cancer",
                    "criterion": "gastric cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    ]
                },
                {
                    "exact_snippets": "T2-4b/N0-3/M0-1 stage",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "T2",
                                "T3",
                                "T4",
                                "T4a",
                                "T4b"
                            ]
                        },
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "N0",
                                "N1",
                                "N2",
                                "N3"
                            ]
                        },
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "M0",
                                "M1"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "according to the eighth edition of the American Joint Committee on Cancer TNM (AJCC TNM) system",
                    "criterion": "staging system",
                    "requirements": [
                        {
                            "requirement_type": "edition",
                            "expected_value": "eighth"
                        },
                        {
                            "requirement_type": "organization",
                            "expected_value": "American Joint Committee on Cancer"
                        },
                        {
                            "requirement_type": "system",
                            "expected_value": "TNM"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Treatment-Naive",
            "criterions": [
                {
                    "exact_snippets": "Treatment-Naive",
                    "criterion": "treatment history",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "naive"
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Not known for other concomitant cancers",
            "criterions": [
                {
                    "exact_snippets": "Not known for other concomitant cancers",
                    "criterion": "concomitant cancers",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Provide written informed consent",
            "criterions": [
                {
                    "exact_snippets": "Provide written informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "provision",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 15 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 15 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 15,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Insufficient tumor tissues (less than 1 cm3)",
            "criterions": [
                {
                    "exact_snippets": "Insufficient tumor tissues (less than 1 cm3)",
                    "criterion": "tumor tissue",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "cm3"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Unable to sign informed consent",
            "criterions": [
                {
                    "exact_snippets": "Unable to sign informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability to sign",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Underwent treatment",
            "criterions": [
                {
                    "exact_snippets": "Underwent treatment",
                    "criterion": "treatment",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": "underwent"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}