{
    "info": {
        "nct_id": "NCT05494320",
        "official_title": "The Effect of ATP-Binding Cassette C2 (ABCC2) Transporter Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin -Based Chemotherapy",
        "inclusion_criteria": "1. gastrointestinal cancer Patients ( ≥ stages II ) who receive Oxaliplatin based chemotherapy ( FOLFOX6 ) for adjuvant and metastatic setting.\n2. Eastern Cooperative Oncology Group ( ECOG ) performance ≤ 2.\n3. Adequate bone marrow functions ,liver functions and renal functions.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Patients who have any clinical neuropathy.\n2. Pateints with Diabetes mellitus.\n3. Serious comorbid systemic disorder incompatible with study.\n4. Pregnancy.\n5. Other primary tumors.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. gastrointestinal cancer Patients ( ≥ stages II ) who receive Oxaliplatin based chemotherapy ( FOLFOX6 ) for adjuvant and metastatic setting.",
            "criterions": [
                {
                    "exact_snippets": "gastrointestinal cancer Patients",
                    "criterion": "gastrointestinal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "( ≥ stages II )",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "receive Oxaliplatin based chemotherapy ( FOLFOX6 )",
                    "criterion": "chemotherapy regimen",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "Oxaliplatin based chemotherapy ( FOLFOX6 )"
                        }
                    ]
                },
                {
                    "exact_snippets": "adjuvant and metastatic setting",
                    "criterion": "treatment setting",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "adjuvant",
                                "metastatic"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Eastern Cooperative Oncology Group ( ECOG ) performance ≤ 2.",
            "criterions": [
                {
                    "exact_snippets": "Eastern Cooperative Oncology Group ( ECOG ) performance ≤ 2",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "performance status",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Patients who have any clinical neuropathy.",
            "criterions": [
                {
                    "exact_snippets": "Patients who have any clinical neuropathy",
                    "criterion": "clinical neuropathy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Pateints with Diabetes mellitus.",
            "criterions": [
                {
                    "exact_snippets": "Diabetes mellitus",
                    "criterion": "Diabetes mellitus",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Serious comorbid systemic disorder incompatible with study.",
            "criterions": [
                {
                    "exact_snippets": "Serious comorbid systemic disorder incompatible with study.",
                    "criterion": "comorbid systemic disorder",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        },
                        {
                            "requirement_type": "compatibility with study",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Pregnancy.",
            "criterions": [
                {
                    "exact_snippets": "Pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Other primary tumors.",
            "criterions": [
                {
                    "exact_snippets": "Other primary tumors.",
                    "criterion": "primary tumors",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "3. Adequate bone marrow functions ,liver functions and renal functions.",
            "criterions": [
                {
                    "exact_snippets": "Adequate bone marrow functions",
                    "criterion": "bone marrow functions",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate ... liver functions",
                    "criterion": "liver functions",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate ... renal functions",
                    "criterion": "renal functions",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    ]
                }
            ]
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}