{
    "info": {
        "nct_id": "NCT05444491",
        "official_title": "Based on the Application of Peripheral Blood Polygene Methylation Markers in Postoperative Recurrence Monitoring of Colorectal Cancer",
        "inclusion_criteria": "1. Newly diagnosed patients with primary colorectal cancer confirmed by histopathology (no restriction on histological type);\n2. Patients diagnosed as stage I-III and feasible for radical bowel surgery;\n3. Patients diagnosed by stage IV (only colorectal cancer patients with liver metastasis at the time of diagnosis) and feasible radical bowel resection or complete resection of liver metastasis;\n4. No gender limitation, age ≥18;\n5. ECOG score ≤1;\n6. Life expectancy ≥5 years;\n7. Those who fully understand the study and voluntarily sign the informed consent.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Blood transfusion was performed during surgery or 2 weeks before surgery;\n2. complicated with primary malignant tumors of other organs;\n3. With colonic obstruction, intestinal perforation and other symptoms requiring emergency treatment;\n4. Colorectal cancer was diagnosed with extrahepatic metastasis;\n5. Neoadjuvant therapy (such as radiotherapy and chemotherapy) before radical bowel resection;\n6. Radical bowel resection was performed after endoscopic surgery;\n7. Concomitant symptoms and/or family history collection suggest hereditary colorectal cancer;\n8. serious mental illness or drug abuse;\n9. patients with serious heart, lung and vascular diseases who cannot tolerate surgery;\n10. pregnant or lactating women;\n11. Participate in other interventional clinical investigators within 3 months\n12. Poor compliance, unable to complete the study according to the judgment of the researcher.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Newly diagnosed patients with primary colorectal cancer confirmed by histopathology (no restriction on histological type);",
            "criterions": [
                {
                    "exact_snippets": "Newly diagnosed patients",
                    "criterion": "diagnosis status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "newly diagnosed"
                        }
                    ]
                },
                {
                    "exact_snippets": "primary colorectal cancer",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "primary colorectal cancer"
                        }
                    ]
                },
                {
                    "exact_snippets": "confirmed by histopathology",
                    "criterion": "confirmation method",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "histopathology"
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Patients diagnosed as stage I-III and feasible for radical bowel surgery;",
            "criterions": [
                {
                    "exact_snippets": "Patients diagnosed as stage I-III",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "feasible for radical bowel surgery",
                    "criterion": "feasibility for radical bowel surgery",
                    "requirements": [
                        {
                            "requirement_type": "feasibility",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Patients diagnosed by stage IV (only colorectal cancer patients with liver metastasis at the time of diagnosis) and feasible radical bowel resection or complete resection of liver metastasis;",
            "criterions": [
                {
                    "exact_snippets": "Patients diagnosed by stage IV (only colorectal cancer patients with liver metastasis at the time of diagnosis)",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    ]
                },
                {
                    "exact_snippets": "colorectal cancer patients",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "colorectal"
                        }
                    ]
                },
                {
                    "exact_snippets": "liver metastasis at the time of diagnosis",
                    "criterion": "liver metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "feasible radical bowel resection",
                    "criterion": "radical bowel resection",
                    "requirements": [
                        {
                            "requirement_type": "feasibility",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "complete resection of liver metastasis",
                    "criterion": "liver metastasis resection",
                    "requirements": [
                        {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. No gender limitation, age ≥18;",
            "criterions": [
                {
                    "exact_snippets": "No gender limitation",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "limitation",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "age ≥18",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. ECOG score ≤1;",
            "criterions": [
                {
                    "exact_snippets": "ECOG score ≤1",
                    "criterion": "ECOG score",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Life expectancy ≥5 years;",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy ≥5 years;",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Those who fully understand the study and voluntarily sign the informed consent.",
            "criterions": [
                {
                    "exact_snippets": "fully understand the study",
                    "criterion": "understanding of the study",
                    "requirements": [
                        {
                            "requirement_type": "comprehension",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "voluntarily sign the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Blood transfusion was performed during surgery or 2 weeks before surgery;",
            "criterions": [
                {
                    "exact_snippets": "Blood transfusion was performed during surgery",
                    "criterion": "blood transfusion",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "during surgery"
                        }
                    ]
                },
                {
                    "exact_snippets": "Blood transfusion was performed ... 2 weeks before surgery",
                    "criterion": "blood transfusion",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "2 weeks before surgery"
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. complicated with primary malignant tumors of other organs;",
            "criterions": [
                {
                    "exact_snippets": "complicated with primary malignant tumors of other organs",
                    "criterion": "primary malignant tumors of other organs",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. With colonic obstruction, intestinal perforation and other symptoms requiring emergency treatment;",
            "criterions": [
                {
                    "exact_snippets": "colonic obstruction",
                    "criterion": "colonic obstruction",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "intestinal perforation",
                    "criterion": "intestinal perforation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other symptoms requiring emergency treatment",
                    "criterion": "symptoms requiring emergency treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Colorectal cancer was diagnosed with extrahepatic metastasis;",
            "criterions": [
                {
                    "exact_snippets": "Colorectal cancer was diagnosed",
                    "criterion": "colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "extrahepatic metastasis",
                    "criterion": "extrahepatic metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Neoadjuvant therapy (such as radiotherapy and chemotherapy) before radical bowel resection;",
            "criterions": [
                {
                    "exact_snippets": "Neoadjuvant therapy (such as radiotherapy and chemotherapy) before radical bowel resection",
                    "criterion": "neoadjuvant therapy",
                    "requirements": [
                        {
                            "requirement_type": "types",
                            "expected_value": [
                                "radiotherapy",
                                "chemotherapy"
                            ]
                        },
                        {
                            "requirement_type": "timing",
                            "expected_value": "before radical bowel resection"
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Radical bowel resection was performed after endoscopic surgery;",
            "criterions": [
                {
                    "exact_snippets": "Radical bowel resection was performed",
                    "criterion": "radical bowel resection",
                    "requirements": [
                        {
                            "requirement_type": "performed",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "after endoscopic surgery",
                    "criterion": "endoscopic surgery",
                    "requirements": [
                        {
                            "requirement_type": "performed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Concomitant symptoms and/or family history collection suggest hereditary colorectal cancer;",
            "criterions": [
                {
                    "exact_snippets": "Concomitant symptoms and/or family history collection suggest hereditary colorectal cancer",
                    "criterion": "hereditary colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "suggestion",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. serious mental illness or drug abuse;",
            "criterions": [
                {
                    "exact_snippets": "serious mental illness",
                    "criterion": "mental illness",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                },
                {
                    "exact_snippets": "drug abuse",
                    "criterion": "drug abuse",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. patients with serious heart, lung and vascular diseases who cannot tolerate surgery;",
            "criterions": [
                {
                    "exact_snippets": "serious heart ... diseases",
                    "criterion": "heart disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                },
                {
                    "exact_snippets": "serious ... lung ... diseases",
                    "criterion": "lung disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                },
                {
                    "exact_snippets": "serious ... vascular diseases",
                    "criterion": "vascular disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                },
                {
                    "exact_snippets": "cannot tolerate surgery",
                    "criterion": "surgical tolerance",
                    "requirements": [
                        {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "10. pregnant or lactating women;",
            "criterions": [
                {
                    "exact_snippets": "pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating women",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "11. Participate in other interventional clinical investigators within 3 months",
            "criterions": [
                {
                    "exact_snippets": "Participate in other interventional clinical investigators within 3 months",
                    "criterion": "participation in other interventional clinical trials",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "12. Poor compliance, unable to complete the study according to the judgment of the researcher.",
            "criterions": [
                {
                    "exact_snippets": "Poor compliance",
                    "criterion": "compliance",
                    "requirements": [
                        {
                            "requirement_type": "quality",
                            "expected_value": "poor"
                        }
                    ]
                },
                {
                    "exact_snippets": "unable to complete the study",
                    "criterion": "ability to complete the study",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}