{
    "info": {
        "nct_id": "NCT04952272",
        "official_title": "Intratumor CpG-ODN Injection Boosters Immune Killing Against in Situ Tumor Antigen Released by Interventional Approaches for Advanced Solid Tumors",
        "inclusion_criteria": "* Solid advanced malignant tumors\n* Age between18 and 80 years\n* Life expectancy is greater than three months\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Benign tumor\n* Life expectancy is less than three months\n* Serious medical comorbidity\n* Others",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Solid advanced malignant tumors",
            "criterions": [
                {
                    "exact_snippets": "Solid advanced malignant tumors",
                    "criterion": "tumor type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "solid"
                        },
                        {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        },
                        {
                            "requirement_type": "malignancy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age between18 and 80 years",
            "criterions": [
                {
                    "exact_snippets": "Age between18 and 80 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Life expectancy is greater than three months",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy is greater than three months",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Benign tumor",
            "criterions": [
                {
                    "exact_snippets": "Benign tumor",
                    "criterion": "tumor",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "benign"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Life expectancy is less than three months",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy is less than three months",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Serious medical comorbidity",
            "criterions": [
                {
                    "exact_snippets": "Serious medical comorbidity",
                    "criterion": "medical comorbidity",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Others",
            "criterions": [
                {
                    "exact_snippets": "Others",
                    "criterion": "other criteria",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}