{
    "info": {
        "nct_id": "NCT04916262",
        "official_title": "Correlation Between TCM Syndrome Factors and TSH Changes of Thyroid Hormone Withdrawal Before Iodine Therapy in Postoperative Patients With Thyroid Cancer",
        "inclusion_criteria": "1. Study time: June 1, 2021, to January 1, 2022;\n2. Study site: The First Affiliated Hospital of Shandong First Medical University;\n3. 18-75 years old (including upper and lower limits), male or female;\n4. Patients with differentiated thyroid carcinoma diagnosed pathologically after total thyroidectomy\n5. Patients with oral levothyroxine tablets ≥ 4 weeks after operation\n6. Patients who have stopped taking levothyroxine tablets and whose TSH < 4.2uIU/ml at the time of withdrawal\n7. Patients who meet the 131I treatment criteria\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "1. Pregnant or lactating women\n2. Patients with various mental disorders, unconscious, etc.\n3. Cases with inaccurate information collection",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Study time: June 1, 2021, to January 1, 2022;",
            "criterions": [
                {
                    "exact_snippets": "Study time: June 1, 2021, to January 1, 2022",
                    "criterion": "study time",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1622505600,
                                        "unit": "timestamp"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1640995200,
                                        "unit": "timestamp"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Study site: The First Affiliated Hospital of Shandong First Medical University;",
            "criterions": [
                {
                    "exact_snippets": "Study site: The First Affiliated Hospital of Shandong First Medical University",
                    "criterion": "study site",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "The First Affiliated Hospital of Shandong First Medical University"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. 18-75 years old (including upper and lower limits), male or female;",
            "criterions": [
                {
                    "exact_snippets": "18-75 years old (including upper and lower limits)",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "male or female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "inclusion",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Patients with differentiated thyroid carcinoma diagnosed pathologically after total thyroidectomy",
            "criterions": [
                {
                    "exact_snippets": "differentiated thyroid carcinoma",
                    "criterion": "differentiated thyroid carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosed pathologically",
                    "criterion": "pathological diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "pathological"
                        }
                    ]
                },
                {
                    "exact_snippets": "after total thyroidectomy",
                    "criterion": "total thyroidectomy",
                    "requirements": [
                        {
                            "requirement_type": "procedure",
                            "expected_value": "completed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Patients with oral levothyroxine tablets ≥ 4 weeks after operation",
            "criterions": [
                {
                    "exact_snippets": "Patients with oral levothyroxine tablets ≥ 4 weeks after operation",
                    "criterion": "oral levothyroxine tablets",
                    "requirements": [
                        {
                            "requirement_type": "duration since operation",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Patients who have stopped taking levothyroxine tablets and whose TSH < 4.2uIU/ml at the time of withdrawal",
            "criterions": [
                {
                    "exact_snippets": "Patients who have stopped taking levothyroxine tablets",
                    "criterion": "levothyroxine tablets",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "stopped"
                        }
                    ]
                },
                {
                    "exact_snippets": "TSH < 4.2uIU/ml at the time of withdrawal",
                    "criterion": "TSH",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 4.2,
                                "unit": "uIU/ml"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Patients who meet the 131I treatment criteria",
            "criterions": [
                {
                    "exact_snippets": "131I treatment criteria",
                    "criterion": "131I treatment criteria",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "met"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Pregnant or lactating women",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating women",
                    "criterion": "lactation status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Patients with various mental disorders, unconscious, etc.",
            "criterions": [
                {
                    "exact_snippets": "Patients with various mental disorders",
                    "criterion": "mental disorders",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "unconscious",
                    "criterion": "consciousness",
                    "requirements": [
                        {
                            "requirement_type": "state",
                            "expected_value": "unconscious"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Cases with inaccurate information collection",
            "criterions": [
                {
                    "exact_snippets": "inaccurate information collection",
                    "criterion": "information collection",
                    "requirements": [
                        {
                            "requirement_type": "accuracy",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}