{
    "info": {
        "nct_id": "NCT04912882",
        "official_title": "Prognosis Predicting of CRC Patients Based on Morphology and Molecular Biomaker of Circulating Tumor Cells",
        "inclusion_criteria": "* Age 18-80 years;\n\nHistologically proven colorectal carcinoma (TNM stage I-IV)\n\nR0 resection is possible according to preoperative evaluation\n\nWritten informed consent for participation in the trial.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Primary tumor or metastases not able to be removed radically\n\nReceiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy)\n\nHave other malignant tumors meanwhile\n\nOther previous malignancy within 5 years",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age 18-80 years;",
            "criterions": [
                {
                    "exact_snippets": "Age 18-80 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Histologically proven colorectal carcinoma (TNM stage I-IV)",
            "criterions": [
                {
                    "exact_snippets": "Histologically proven colorectal carcinoma",
                    "criterion": "colorectal carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis method",
                            "expected_value": "histologically proven"
                        }
                    ]
                },
                {
                    "exact_snippets": "TNM stage I-IV",
                    "criterion": "TNM stage",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "R0 resection is possible according to preoperative evaluation",
            "criterions": [
                {
                    "exact_snippets": "R0 resection is possible according to preoperative evaluation",
                    "criterion": "R0 resection",
                    "requirements": [
                        {
                            "requirement_type": "possibility",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Written informed consent for participation in the trial.",
            "criterions": [
                {
                    "exact_snippets": "Written informed consent for participation in the trial.",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Primary tumor or metastases not able to be removed radically",
            "criterions": [
                {
                    "exact_snippets": "Primary tumor or metastases not able to be removed radically",
                    "criterion": "primary tumor",
                    "requirements": [
                        {
                            "requirement_type": "removability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Primary tumor or metastases not able to be removed radically",
                    "criterion": "metastases",
                    "requirements": [
                        {
                            "requirement_type": "removability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy)",
            "criterions": [
                {
                    "exact_snippets": "Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy)",
                    "criterion": "preoperative treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Have other malignant tumors meanwhile",
            "criterions": [
                {
                    "exact_snippets": "Have other malignant tumors",
                    "criterion": "malignant tumors",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Other previous malignancy within 5 years",
            "criterions": [
                {
                    "exact_snippets": "Other previous malignancy within 5 years",
                    "criterion": "previous malignancy",
                    "requirements": [
                        {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}