{
    "info": {
        "nct_id": "NCT04864431",
        "official_title": "The Effect of Vitamin D on Factors Contributing Pre Cachexia and Cachexia, a Study on Epithelial Ovarian Cancer",
        "inclusion_criteria": "1. age 18-60 years old who are newly diagnosed with ovarian cancer based on histopathology\n2. epithelial ovarian cancer stage II-III\n3. haven't received chemotherapy\n4. pre-cachexia or cachexia\n5. level of vitamin D below 30 ng/ml\n6. no vitamin D allergy\n7. ability and willingness to understand and provide informed consent\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 60 Years",
        "exclusion_criteria": "1. autoimmune disease\n2. chronic liver disease\n3. chronic renal disease\n4. known had hypercalcemia\n5. refractory cachexia",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. age 18-60 years old who are newly diagnosed with ovarian cancer based on histopathology",
            "criterions": [
                {
                    "exact_snippets": "age 18-60 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 60,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "newly diagnosed with ovarian cancer",
                    "criterion": "ovarian cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "newly diagnosed"
                        }
                    ]
                },
                {
                    "exact_snippets": "based on histopathology",
                    "criterion": "diagnosis method",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "histopathology"
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. epithelial ovarian cancer stage II-III",
            "criterions": [
                {
                    "exact_snippets": "epithelial ovarian cancer",
                    "criterion": "epithelial ovarian cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "stage II-III",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. haven't received chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "haven't received chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "receipt",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. pre-cachexia or cachexia",
            "criterions": [
                {
                    "exact_snippets": "pre-cachexia or cachexia",
                    "criterion": "cachexia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "pre-cachexia or cachexia",
                    "criterion": "pre-cachexia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. level of vitamin D below 30 ng/ml",
            "criterions": [
                {
                    "exact_snippets": "level of vitamin D below 30 ng/ml",
                    "criterion": "vitamin D level",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "ng/ml"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. no vitamin D allergy",
            "criterions": [
                {
                    "exact_snippets": "no vitamin D allergy",
                    "criterion": "vitamin D allergy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. ability and willingness to understand and provide informed consent",
            "criterions": [
                {
                    "exact_snippets": "ability ... to understand and provide informed consent",
                    "criterion": "ability to understand and provide informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willingness to understand and provide informed consent",
                    "criterion": "willingness to understand and provide informed consent",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 60 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 60 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 60,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. autoimmune disease",
            "criterions": [
                {
                    "exact_snippets": "autoimmune disease",
                    "criterion": "autoimmune disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. chronic liver disease",
            "criterions": [
                {
                    "exact_snippets": "chronic liver disease",
                    "criterion": "chronic liver disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. chronic renal disease",
            "criterions": [
                {
                    "exact_snippets": "chronic renal disease",
                    "criterion": "chronic renal disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. known had hypercalcemia",
            "criterions": [
                {
                    "exact_snippets": "known had hypercalcemia",
                    "criterion": "hypercalcemia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. refractory cachexia",
            "criterions": [
                {
                    "exact_snippets": "refractory cachexia",
                    "criterion": "cachexia",
                    "requirements": [
                        {
                            "requirement_type": "refractory",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}