{
    "info": {
        "nct_id": "NCT04716920",
        "official_title": "Tai Chi for Relieving Aromatase Inhibitor-Induced Arthralgia in Breast Cancer Patients",
        "inclusion_criteria": "* Be able to speak and read English\n* Been diagnosed with stage I-III breast cancer (BC)\n* Had completed all active treatments\n* Had been receiving an AI (anastrozole, letrozole, or exemestane) for at least 3 months\n* Had joint (knee, hand or hip) pain or stiffness that started or worsened after the initiation of AI\n* Report worst pain in the past week >= 4 on a 0-10 numeric rating scale\n* Be willing to adhere to all study procedures\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Has been diagnosed with another form of cancer in the past 5 years\n* Uncontrolled cardiac, pulmonary, or infectious disease\n* Body mass index (BMI) > 40 kg/m^2\n* Currently attending any mind-body therapy classes (e.g. yoga)\n* Joint pain due to inflammatory arthritic condition (such as rheumatoid arthritis, osteoarthritis or gout, which will be assessed during eligibility screening with patient self-reported data and will be screened through electronic medical record [EMR] data)\n* Had surgery or joint infection in the past 6 months\n* Currently taking corticosteroids or opioids, have discontinued or plan to discontinue AI in the next 6 months",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Be able to speak and read English",
            "criterions": [
                {
                    "exact_snippets": "speak and read English",
                    "criterion": "English language proficiency",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": [
                                "speak",
                                "read"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Been diagnosed with stage I-III breast cancer (BC)",
            "criterions": [
                {
                    "exact_snippets": "diagnosed with stage I-III breast cancer (BC)",
                    "criterion": "breast cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Had completed all active treatments",
            "criterions": [
                {
                    "exact_snippets": "completed all active treatments",
                    "criterion": "active treatment completion",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Had been receiving an AI (anastrozole, letrozole, or exemestane) for at least 3 months",
            "criterions": [
                {
                    "exact_snippets": "receiving an AI (anastrozole, letrozole, or exemestane)",
                    "criterion": "aromatase inhibitor (AI) therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "at least 3 months",
                    "criterion": "duration of AI therapy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Had joint (knee, hand or hip) pain or stiffness that started or worsened after the initiation of AI",
            "criterions": [
                {
                    "exact_snippets": "joint (knee, hand or hip) pain or stiffness",
                    "criterion": "joint pain or stiffness",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "knee",
                                "hand",
                                "hip"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "started or worsened after the initiation of AI",
                    "criterion": "onset or worsening of joint pain or stiffness",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "after the initiation of AI"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Report worst pain in the past week >= 4 on a 0-10 numeric rating scale",
            "criterions": [
                {
                    "exact_snippets": "worst pain in the past week >= 4 on a 0-10 numeric rating scale",
                    "criterion": "worst pain",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "0-10 numeric rating scale"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Be willing to adhere to all study procedures",
            "criterions": [
                {
                    "exact_snippets": "willing to adhere to all study procedures",
                    "criterion": "adherence to study procedures",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Has been diagnosed with another form of cancer in the past 5 years",
            "criterions": [
                {
                    "exact_snippets": "diagnosed with another form of cancer in the past 5 years",
                    "criterion": "another form of cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Uncontrolled cardiac, pulmonary, or infectious disease",
            "criterions": [
                {
                    "exact_snippets": "Uncontrolled cardiac ... disease",
                    "criterion": "cardiac disease",
                    "requirements": [
                        {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    ]
                },
                {
                    "exact_snippets": "Uncontrolled ... pulmonary ... disease",
                    "criterion": "pulmonary disease",
                    "requirements": [
                        {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    ]
                },
                {
                    "exact_snippets": "Uncontrolled ... infectious disease",
                    "criterion": "infectious disease",
                    "requirements": [
                        {
                            "requirement_type": "control status",
                            "expected_value": "uncontrolled"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Body mass index (BMI) > 40 kg/m^2",
            "criterions": [
                {
                    "exact_snippets": "Body mass index (BMI) > 40 kg/m^2",
                    "criterion": "body mass index (BMI)",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 40,
                                "unit": "kg/m^2"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Currently attending any mind-body therapy classes (e.g. yoga)",
            "criterions": [
                {
                    "exact_snippets": "Currently attending any mind-body therapy classes (e.g. yoga)",
                    "criterion": "mind-body therapy classes attendance",
                    "requirements": [
                        {
                            "requirement_type": "attendance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Joint pain due to inflammatory arthritic condition (such as rheumatoid arthritis, osteoarthritis or gout, which will be assessed during eligibility screening with patient self-reported data and will be screened through electronic medical record [EMR] data)",
            "criterions": [
                {
                    "exact_snippets": "Joint pain due to inflammatory arthritic condition (such as rheumatoid arthritis, osteoarthritis or gout",
                    "criterion": "inflammatory arthritic condition",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Joint pain",
                    "criterion": "joint pain",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Had surgery or joint infection in the past 6 months",
            "criterions": [
                {
                    "exact_snippets": "Had surgery ... in the past 6 months",
                    "criterion": "surgery",
                    "requirements": [
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "joint infection in the past 6 months",
                    "criterion": "joint infection",
                    "requirements": [
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Currently taking corticosteroids or opioids, have discontinued or plan to discontinue AI in the next 6 months",
            "criterions": [
                {
                    "exact_snippets": "Currently taking corticosteroids",
                    "criterion": "corticosteroid use",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Currently taking ... opioids",
                    "criterion": "opioid use",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "have discontinued ... AI",
                    "criterion": "AI discontinuation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "plan to discontinue AI in the next 6 months",
                    "criterion": "AI discontinuation plan",
                    "requirements": [
                        {
                            "requirement_type": "timeframe",
                            "expected_value": "next 6 months"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}