{
    "info": {
        "nct_id": "NCT04707482",
        "official_title": "Cohort Study of Mechanism and Process Regulation for Colorectal Tumors",
        "inclusion_criteria": "* Inclusion Criteria（Healthy control group）： 1) Aged more than 18 years; 2) Planned to undergo colonoscopy , without past medical history of neoplasm or ulcer or bleeding under colonoscopy regardless of the history of colonoscopy; 3) Willing to participate in this trial and signed the informed consent.\n\n  * Inclusion Criteria（Sporadic colorectal adenoma group）：\n\n    1. More than 18 years aged;\n    2. Diagnosed as colorectal adenoma, epithelial adenomatoid hyperplasia, serrated lesions, or with mild to moderate dysplasia (low-grade intraepithelial neoplasia) by colonoscopy and pathology;\n    3. Signed the informed consent, willing to participate in this trial.\n  * Inclusion Criteria（Sporadic early colorectal cancer group）：\n\n    1. Aged more than 18 years;\n    2. Underwent endoscopic EMR/ESD or Surgical resection because of colorectal neoplasms and the lesion was confined to the mucosa or submucosa of the large intestine and was pathologically indicated to be adenocarcinoma;\n    3. Willing to participate in this trial and signed the informed consent.\n  * Inclusion Criteria（Familial colorectal neoplasm group）：\n\n    1. Aged more than 18 years;\n    2. Underwent ESD/EMR resection or surgical resection and the pathology result considered as early colorectal cancer and adenoma, and the family history, pathology and genetic tests met the diagnostic criteria of FAP and HNPCC/LS;\n    3. Signed the informed consent, willing to participate in this trial. ·-Inclusion Criteria (Cohort study)\n\n    <!-- -->\n\n    1. Aged 18-80 years;\n    2. Diagnosed as polypoid neoplasm or lateral developmental neoplasm (LST) by endoscopy without a family history of CRC and the pathologic manifestations were conventional adenoma or serrated lesions; the patients without a family history of CRC underwent ESD or EMR resection and the pathology result considered as early colorectal cancer; diagnosed as sporadic colorectal early carcinoma and adenoma with a family history of colorectal cancer (FAP, Lynch syndrome);\n    3. Signed the informed consent, willing to participate in this study and agreed with colonoscopy with pathology examination once a year and followed up for 5 years.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* -Exclusion Criteria（Healthy control group）：\n\n  1. With a medical history of digestive tract rerouting and partial resection;\n  2. Patients with high risk of hereditary colorectal adenocarcinoma, i.e. family members of the following diseases: family history of gastrointestinal neoplasms, familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS), and P-J syndrome;\n  3. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;\n  4. With other malignancies known to have advanced or require treatment in the past 5 years, except basal cell and squamous cell carcinoma of the skin that have been radically cured;\n  5. With a history of active gastrointestinal bleeding within the last 6 months;\n  6. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;\n  7. Received routine immunosuppressive drugs for the past 6 months;\n  8. Unable or unwilling to cooperate with follow-up and related examinations;\n  9. Patients who can not eat normally or need to rely on medicine or enema and other defecation;\n  10. With mental illness or any other serious cardiovascular disease;\n  11. With pregnant or lactating or planning to become pregnant within one year;\n  12. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.\n* Exclusion Criteria（Sporadic colorectal adenoma group）：\n\n  1. With a medical history of digestive tract rerouting and partial resection;\n  2. Patients with high risk of hereditary colorectal adenocarcinoma, i.e. family members of the following diseases: family history of gastrointestinal neoplasms, familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS), and P-J syndrome;\n  3. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;\n  4. With other malignancies known to have advanced or require treatment in the past 5 years, except basal cell and squamous cell carcinoma of the skin that have been radically cured;\n  5. With a history of active gastrointestinal bleeding within the last 6 months;\n  6. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;\n  7. Received routine immunosuppressive drugs for the past 6 months;\n  8. Unable or unwilling to cooperate with follow-up and related examinations;\n  9. Patients who can not eat normally or need to rely on medicine or enema and other defecation;\n  10. With mental illness or any other serious cardiovascular disease;\n  11. With pregnant or lactating or planning to become pregnant within one year;\n  12. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.\n* Exclusion Criteria（Sporadic early colorectal cancer group）：\n\n  1. With a medical history of digestive tract rerouting and partial resection;\n  2. Patients with high risk of hereditary colorectal adenocarcinoma, i.e. family members of the following diseases: family history of gastrointestinal neoplasms, familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS), and P-J syndrome;\n  3. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;\n  4. With other malignancies known to have advanced or require treatment in the past 5 years, except basal cell and squamous cell carcinoma of the skin that have been radically cured;\n  5. With a history of active gastrointestinal bleeding within the last 6 months;\n  6. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;\n  7. Received routine immunosuppressive drugs for the past 6 months;\n  8. Unable or unwilling to cooperate with follow-up and related examinations;\n  9. Patients who can not eat normally or need to rely on medicine or enema and other defecation;\n  10. With mental illness or any other serious cardiovascular disease;\n  11. With pregnant or lactating or planning to become pregnant within one year;\n  12. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.\n* Exclusion Criteria（Familial colorectal neoplasm group）：\n\n  1. With a medical history of digestive tract rerouting and partial resection;\n  2. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;\n  3. With a history of active gastrointestinal bleeding within the last 6 months;\n  4. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;\n  5. Received routine immunosuppressive drugs for the past 6 months;\n  6. Unable or unwilling to cooperate with follow-up and related examinations;\n  7. Patients who can not eat normally or need to rely on medicine or enema and other defecation;\n  8. With mental illness or any other serious cardiovascular disease;\n  9. With pregnant or lactating or planning to become pregnant within one year;\n  10. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.\n\n      * Exclusion Criteria（Cohort study）\n\nExcept baseline exclusion criteria, and the following conditions should be excluded:\n\n1. Diagnosed as advanced colorectal cancer (with or without surgery, radiation, chemotherapy, targeted therapy, immunotherapy);\n2. Refuse to sign the informed consent.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Inclusion Criteria（Healthy control group）： 1) Aged more than 18 years; 2) Planned to undergo colonoscopy , without past medical history of neoplasm or ulcer or bleeding under colonoscopy regardless of the history of colonoscopy; 3) Willing to participate in this trial and signed the informed consent.",
            "criterions": [
                {
                    "exact_snippets": "Aged more than 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Planned to undergo colonoscopy",
                    "criterion": "planned colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "planned procedure",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "without past medical history of neoplasm",
                    "criterion": "past medical history of neoplasm",
                    "requirements": [
                        {
                            "requirement_type": "absence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "without past medical history of ... ulcer",
                    "criterion": "past medical history of ulcer",
                    "requirements": [
                        {
                            "requirement_type": "absence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "without past medical history of ... bleeding under colonoscopy",
                    "criterion": "past medical history of bleeding under colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "absence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Willing to participate in this trial",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "signed the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inclusion Criteria（Sporadic colorectal adenoma group）：",
            "criterions": [
                {
                    "exact_snippets": "Sporadic colorectal adenoma group",
                    "criterion": "colorectal adenoma",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "sporadic"
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. More than 18 years aged;",
            "criterions": [
                {
                    "exact_snippets": "More than 18 years aged",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Diagnosed as colorectal adenoma, epithelial adenomatoid hyperplasia, serrated lesions, or with mild to moderate dysplasia (low-grade intraepithelial neoplasia) by colonoscopy and pathology;",
            "criterions": [
                {
                    "exact_snippets": "Diagnosed as colorectal adenoma",
                    "criterion": "colorectal adenoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "epithelial adenomatoid hyperplasia",
                    "criterion": "epithelial adenomatoid hyperplasia",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "serrated lesions",
                    "criterion": "serrated lesions",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "mild to moderate dysplasia (low-grade intraepithelial neoplasia)",
                    "criterion": "mild to moderate dysplasia",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Signed the informed consent, willing to participate in this trial.",
            "criterions": [
                {
                    "exact_snippets": "Signed the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willing to participate in this trial",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. Aged more than 18 years;",
            "criterions": [
                {
                    "exact_snippets": "Aged more than 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Underwent endoscopic EMR/ESD or Surgical resection because of colorectal neoplasms and the lesion was confined to the mucosa or submucosa of the large intestine and was pathologically indicated to be adenocarcinoma;",
            "criterions": [
                {
                    "exact_snippets": "Underwent endoscopic EMR/ESD or Surgical resection",
                    "criterion": "procedure",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "endoscopic EMR/ESD",
                                "Surgical resection"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "because of colorectal neoplasms",
                    "criterion": "condition",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "colorectal neoplasms"
                        }
                    ]
                },
                {
                    "exact_snippets": "lesion was confined to the mucosa or submucosa of the large intestine",
                    "criterion": "lesion location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "mucosa",
                                "submucosa"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "pathologically indicated to be adenocarcinoma",
                    "criterion": "pathological indication",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "adenocarcinoma"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Willing to participate in this trial and signed the informed consent.",
            "criterions": [
                {
                    "exact_snippets": "Willing to participate in this trial",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "signed the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inclusion Criteria（Familial colorectal neoplasm group）：",
            "criterions": [
                {
                    "exact_snippets": "Familial colorectal neoplasm group",
                    "criterion": "familial colorectal neoplasm",
                    "requirements": [
                        {
                            "requirement_type": "group membership",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. Aged more than 18 years;",
            "criterions": [
                {
                    "exact_snippets": "Aged more than 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Underwent ESD/EMR resection or surgical resection and the pathology result considered as early colorectal cancer and adenoma, and the family history, pathology and genetic tests met the diagnostic criteria of FAP and HNPCC/LS;",
            "criterions": [
                {
                    "exact_snippets": "Underwent ESD/EMR resection or surgical resection",
                    "criterion": "resection type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "ESD",
                                "EMR",
                                "surgical"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "pathology result considered as early colorectal cancer and adenoma",
                    "criterion": "pathology result",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": [
                                "early colorectal cancer",
                                "adenoma"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "family history, pathology and genetic tests met the diagnostic criteria of FAP",
                    "criterion": "FAP diagnostic criteria",
                    "requirements": [
                        {
                            "requirement_type": "diagnostic criteria",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "family history, pathology and genetic tests met the diagnostic criteria of ... HNPCC/LS",
                    "criterion": "HNPCC/LS diagnostic criteria",
                    "requirements": [
                        {
                            "requirement_type": "diagnostic criteria",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Signed the informed consent, willing to participate in this trial. ·-Inclusion Criteria (Cohort study)",
            "criterions": [
                {
                    "exact_snippets": "Signed the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willing to participate in this trial",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. Aged 18-80 years;",
            "criterions": [
                {
                    "exact_snippets": "Aged 18-80 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Diagnosed as polypoid neoplasm or lateral developmental neoplasm (LST) by endoscopy without a family history of CRC and the pathologic manifestations were conventional adenoma or serrated lesions; the patients without a family history of CRC underwent ESD or EMR resection and the pathology result considered as early colorectal cancer; diagnosed as sporadic colorectal early carcinoma and adenoma with a family history of colorectal cancer (FAP, Lynch syndrome);",
            "criterions": [
                {
                    "exact_snippets": "Diagnosed as polypoid neoplasm or lateral developmental neoplasm (LST) by endoscopy",
                    "criterion": "neoplasm type",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": [
                                "polypoid neoplasm",
                                "lateral developmental neoplasm (LST)"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "without a family history of CRC",
                    "criterion": "family history of CRC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "pathologic manifestations were conventional adenoma or serrated lesions",
                    "criterion": "pathologic manifestations",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "conventional adenoma",
                                "serrated lesions"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "patients without a family history of CRC underwent ESD or EMR resection",
                    "criterion": "family history of CRC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "pathology result considered as early colorectal cancer",
                    "criterion": "pathology result",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": "early colorectal cancer"
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosed as sporadic colorectal early carcinoma and adenoma with a family history of colorectal cancer (FAP, Lynch syndrome)",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "sporadic colorectal early carcinoma",
                                "adenoma"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "with a family history of colorectal cancer (FAP, Lynch syndrome)",
                    "criterion": "family history of colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Signed the informed consent, willing to participate in this study and agreed with colonoscopy with pathology examination once a year and followed up for 5 years.",
            "criterions": [
                {
                    "exact_snippets": "Signed the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willing to participate in this study",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "agreed with colonoscopy with pathology examination once a year",
                    "criterion": "colonoscopy with pathology examination",
                    "requirements": [
                        {
                            "requirement_type": "frequency",
                            "expected_value": "once a year"
                        }
                    ]
                },
                {
                    "exact_snippets": "followed up for 5 years",
                    "criterion": "follow-up duration",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": "5 years"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. With a medical history of digestive tract rerouting and partial resection;",
            "criterions": [
                {
                    "exact_snippets": "medical history of digestive tract rerouting",
                    "criterion": "digestive tract rerouting",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "medical history of ... partial resection",
                    "criterion": "partial resection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Patients with high risk of hereditary colorectal adenocarcinoma, i.e. family members of the following diseases: family history of gastrointestinal neoplasms, familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS), and P-J syndrome;",
            "criterions": [
                {
                    "exact_snippets": "high risk of hereditary colorectal adenocarcinoma",
                    "criterion": "hereditary colorectal adenocarcinoma risk",
                    "requirements": [
                        {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    ]
                },
                {
                    "exact_snippets": "family history of gastrointestinal neoplasms",
                    "criterion": "family history of gastrointestinal neoplasms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "familial adenomatous polyposis (FAP)",
                    "criterion": "familial adenomatous polyposis (FAP)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS)",
                    "criterion": "hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "P-J syndrome",
                    "criterion": "P-J syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;",
            "criterions": [
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as hypertension",
                    "criterion": "hypertension",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... diabetes",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... chronic viral hepatitis",
                    "criterion": "chronic viral hepatitis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... inflammatory bowel disease",
                    "criterion": "inflammatory bowel disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. With other malignancies known to have advanced or require treatment in the past 5 years, except basal cell and squamous cell carcinoma of the skin that have been radically cured;",
            "criterions": [
                {
                    "exact_snippets": "other malignancies known to have advanced or require treatment in the past 5 years",
                    "criterion": "other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "advancement",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "treatment requirement",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "basal cell and squamous cell carcinoma of the skin that have been radically cured",
                    "criterion": "basal cell and squamous cell carcinoma of the skin",
                    "requirements": [
                        {
                            "requirement_type": "cure status",
                            "expected_value": "radically cured"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. With a history of active gastrointestinal bleeding within the last 6 months;",
            "criterions": [
                {
                    "exact_snippets": "history of active gastrointestinal bleeding within the last 6 months",
                    "criterion": "gastrointestinal bleeding",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;",
            "criterions": [
                {
                    "exact_snippets": "history of using broad-spectrum antibiotics ... within the past 1 month",
                    "criterion": "broad-spectrum antibiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                },
                {
                    "exact_snippets": "history of using ... probiotics by oral or intravenous within the past 1 month",
                    "criterion": "probiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Received routine immunosuppressive drugs for the past 6 months;",
            "criterions": [
                {
                    "exact_snippets": "Received routine immunosuppressive drugs for the past 6 months",
                    "criterion": "immunosuppressive drug use",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Unable or unwilling to cooperate with follow-up and related examinations;",
            "criterions": [
                {
                    "exact_snippets": "Unable or unwilling to cooperate with follow-up and related examinations",
                    "criterion": "cooperation with follow-up and related examinations",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. Patients who can not eat normally or need to rely on medicine or enema and other defecation;",
            "criterions": [
                {
                    "exact_snippets": "Patients who can not eat normally",
                    "criterion": "ability to eat normally",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "need to rely on medicine or enema and other defecation",
                    "criterion": "reliance on medicine or enema for defecation",
                    "requirements": [
                        {
                            "requirement_type": "reliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "10. With mental illness or any other serious cardiovascular disease;",
            "criterions": [
                {
                    "exact_snippets": "mental illness",
                    "criterion": "mental illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "serious cardiovascular disease",
                    "criterion": "cardiovascular disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                }
            ]
        },
        {
            "line": "11. With pregnant or lactating or planning to become pregnant within one year;",
            "criterions": [
                {
                    "exact_snippets": "pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating",
                    "criterion": "lactation status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "planning to become pregnant within one year",
                    "criterion": "pregnancy plans",
                    "requirements": [
                        {
                            "requirement_type": "timeframe",
                            "expected_value": "within one year"
                        }
                    ]
                }
            ]
        },
        {
            "line": "12. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.",
            "criterions": [
                {
                    "exact_snippets": "Currently participating in, or receiving, an interventional clinical study",
                    "criterion": "participation in interventional clinical study",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "affects patients' treatment decisions",
                    "criterion": "study affecting treatment decisions",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. With a medical history of digestive tract rerouting and partial resection;",
            "criterions": [
                {
                    "exact_snippets": "medical history of digestive tract rerouting",
                    "criterion": "digestive tract rerouting",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "medical history of ... partial resection",
                    "criterion": "partial resection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Patients with high risk of hereditary colorectal adenocarcinoma, i.e. family members of the following diseases: family history of gastrointestinal neoplasms, familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS), and P-J syndrome;",
            "criterions": [
                {
                    "exact_snippets": "high risk of hereditary colorectal adenocarcinoma",
                    "criterion": "hereditary colorectal adenocarcinoma risk",
                    "requirements": [
                        {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    ]
                },
                {
                    "exact_snippets": "family history of gastrointestinal neoplasms",
                    "criterion": "family history of gastrointestinal neoplasms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "familial adenomatous polyposis (FAP)",
                    "criterion": "familial adenomatous polyposis (FAP)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS)",
                    "criterion": "hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "P-J syndrome",
                    "criterion": "P-J syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;",
            "criterions": [
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as hypertension",
                    "criterion": "hypertension",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... diabetes",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... chronic viral hepatitis",
                    "criterion": "chronic viral hepatitis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... inflammatory bowel disease",
                    "criterion": "inflammatory bowel disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. With other malignancies known to have advanced or require treatment in the past 5 years, except basal cell and squamous cell carcinoma of the skin that have been radically cured;",
            "criterions": [
                {
                    "exact_snippets": "other malignancies known to have advanced or require treatment in the past 5 years",
                    "criterion": "other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "advanced"
                        },
                        {
                            "requirement_type": "treatment",
                            "expected_value": "required in the past 5 years"
                        }
                    ]
                },
                {
                    "exact_snippets": "except basal cell and squamous cell carcinoma of the skin that have been radically cured",
                    "criterion": "basal cell and squamous cell carcinoma of the skin",
                    "requirements": [
                        {
                            "requirement_type": "treatment outcome",
                            "expected_value": "radically cured"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. With a history of active gastrointestinal bleeding within the last 6 months;",
            "criterions": [
                {
                    "exact_snippets": "history of active gastrointestinal bleeding within the last 6 months",
                    "criterion": "gastrointestinal bleeding",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;",
            "criterions": [
                {
                    "exact_snippets": "history of using broad-spectrum antibiotics",
                    "criterion": "broad-spectrum antibiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                },
                {
                    "exact_snippets": "history of using ... probiotics by oral or intravenous",
                    "criterion": "probiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Received routine immunosuppressive drugs for the past 6 months;",
            "criterions": [
                {
                    "exact_snippets": "Received routine immunosuppressive drugs for the past 6 months",
                    "criterion": "immunosuppressive drug use",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Unable or unwilling to cooperate with follow-up and related examinations;",
            "criterions": [
                {
                    "exact_snippets": "Unable or unwilling to cooperate with follow-up and related examinations",
                    "criterion": "cooperation with follow-up and related examinations",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. Patients who can not eat normally or need to rely on medicine or enema and other defecation;",
            "criterions": [
                {
                    "exact_snippets": "Patients who can not eat normally",
                    "criterion": "ability to eat normally",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "need to rely on medicine or enema and other defecation",
                    "criterion": "reliance on medicine or enema for defecation",
                    "requirements": [
                        {
                            "requirement_type": "reliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "10. With mental illness or any other serious cardiovascular disease;",
            "criterions": [
                {
                    "exact_snippets": "mental illness",
                    "criterion": "mental illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "serious cardiovascular disease",
                    "criterion": "cardiovascular disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                }
            ]
        },
        {
            "line": "11. With pregnant or lactating or planning to become pregnant within one year;",
            "criterions": [
                {
                    "exact_snippets": "pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating",
                    "criterion": "lactation status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "planning to become pregnant within one year",
                    "criterion": "pregnancy plans",
                    "requirements": [
                        {
                            "requirement_type": "timeframe",
                            "expected_value": "within one year"
                        }
                    ]
                }
            ]
        },
        {
            "line": "12. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.",
            "criterions": [
                {
                    "exact_snippets": "Currently participating in, or receiving, an interventional clinical study",
                    "criterion": "participation in interventional clinical study",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "affects patients' treatment decisions",
                    "criterion": "study affecting treatment decisions",
                    "requirements": [
                        {
                            "requirement_type": "impact",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. With a medical history of digestive tract rerouting and partial resection;",
            "criterions": [
                {
                    "exact_snippets": "medical history of digestive tract rerouting",
                    "criterion": "digestive tract rerouting",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "medical history of ... partial resection",
                    "criterion": "partial resection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Patients with high risk of hereditary colorectal adenocarcinoma, i.e. family members of the following diseases: family history of gastrointestinal neoplasms, familial adenomatous polyposis (FAP), hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS), and P-J syndrome;",
            "criterions": [
                {
                    "exact_snippets": "high risk of hereditary colorectal adenocarcinoma",
                    "criterion": "hereditary colorectal adenocarcinoma risk",
                    "requirements": [
                        {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    ]
                },
                {
                    "exact_snippets": "family history of gastrointestinal neoplasms",
                    "criterion": "family history of gastrointestinal neoplasms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "familial adenomatous polyposis (FAP)",
                    "criterion": "familial adenomatous polyposis (FAP)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS)",
                    "criterion": "hereditary non-polyposis colorectal adenocarcinoma (HNPCC/LS)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "P-J syndrome",
                    "criterion": "P-J syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;",
            "criterions": [
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as hypertension",
                    "criterion": "hypertension",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... diabetes",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... chronic viral hepatitis",
                    "criterion": "chronic viral hepatitis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... inflammatory bowel disease",
                    "criterion": "inflammatory bowel disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. With other malignancies known to have advanced or require treatment in the past 5 years, except basal cell and squamous cell carcinoma of the skin that have been radically cured;",
            "criterions": [
                {
                    "exact_snippets": "other malignancies known to have advanced or require treatment in the past 5 years",
                    "criterion": "other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "advanced"
                        },
                        {
                            "requirement_type": "treatment",
                            "expected_value": "required in the past 5 years"
                        }
                    ]
                },
                {
                    "exact_snippets": "basal cell and squamous cell carcinoma of the skin that have been radically cured",
                    "criterion": "basal cell and squamous cell carcinoma of the skin",
                    "requirements": [
                        {
                            "requirement_type": "treatment outcome",
                            "expected_value": "radically cured"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. With a history of active gastrointestinal bleeding within the last 6 months;",
            "criterions": [
                {
                    "exact_snippets": "history of active gastrointestinal bleeding within the last 6 months",
                    "criterion": "gastrointestinal bleeding",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;",
            "criterions": [
                {
                    "exact_snippets": "history of using broad-spectrum antibiotics ... within the past 1 month",
                    "criterion": "broad-spectrum antibiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                },
                {
                    "exact_snippets": "history of using ... probiotics by oral or intravenous within the past 1 month",
                    "criterion": "probiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Received routine immunosuppressive drugs for the past 6 months;",
            "criterions": [
                {
                    "exact_snippets": "Received routine immunosuppressive drugs for the past 6 months",
                    "criterion": "immunosuppressive drug use",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Unable or unwilling to cooperate with follow-up and related examinations;",
            "criterions": [
                {
                    "exact_snippets": "Unable or unwilling to cooperate with follow-up and related examinations",
                    "criterion": "cooperation with follow-up and related examinations",
                    "requirements": [
                        {
                            "requirement_type": "ability and willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. Patients who can not eat normally or need to rely on medicine or enema and other defecation;",
            "criterions": [
                {
                    "exact_snippets": "Patients who can not eat normally",
                    "criterion": "ability to eat normally",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "need to rely on medicine or enema and other defecation",
                    "criterion": "reliance on medicine or enema for defecation",
                    "requirements": [
                        {
                            "requirement_type": "reliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "10. With mental illness or any other serious cardiovascular disease;",
            "criterions": [
                {
                    "exact_snippets": "mental illness",
                    "criterion": "mental illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "serious cardiovascular disease",
                    "criterion": "cardiovascular disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        },
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "11. With pregnant or lactating or planning to become pregnant within one year;",
            "criterions": [
                {
                    "exact_snippets": "pregnant",
                    "criterion": "pregnancy status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating",
                    "criterion": "lactation status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "planning to become pregnant within one year",
                    "criterion": "pregnancy planning",
                    "requirements": [
                        {
                            "requirement_type": "timeframe",
                            "expected_value": "within one year"
                        }
                    ]
                }
            ]
        },
        {
            "line": "12. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.",
            "criterions": [
                {
                    "exact_snippets": "Currently participating in, or receiving, an interventional clinical study",
                    "criterion": "participation in interventional clinical study",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "affects patients' treatment decisions",
                    "criterion": "impact on treatment decisions",
                    "requirements": [
                        {
                            "requirement_type": "impact",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Exclusion Criteria（Familial colorectal neoplasm group）：",
            "criterions": [
                {
                    "exact_snippets": "Familial colorectal neoplasm group",
                    "criterion": "familial colorectal neoplasm",
                    "requirements": [
                        {
                            "requirement_type": "group membership",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. With a medical history of digestive tract rerouting and partial resection;",
            "criterions": [
                {
                    "exact_snippets": "medical history of digestive tract rerouting",
                    "criterion": "digestive tract rerouting",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "medical history of ... partial resection",
                    "criterion": "partial resection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. With A history of chronic metabolic and inflammatory diseases such as hypertension, diabetes, chronic viral hepatitis, and inflammatory bowel disease and the chronic disease were difficult to control;",
            "criterions": [
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as hypertension",
                    "criterion": "hypertension",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... diabetes",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... chronic viral hepatitis",
                    "criterion": "chronic viral hepatitis",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of chronic metabolic and inflammatory diseases such as ... inflammatory bowel disease",
                    "criterion": "inflammatory bowel disease",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "control difficulty",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. With a history of active gastrointestinal bleeding within the last 6 months;",
            "criterions": [
                {
                    "exact_snippets": "history of active gastrointestinal bleeding within the last 6 months",
                    "criterion": "gastrointestinal bleeding",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "recency",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. With a history of using broad-spectrum antibiotics and probiotics by oral or intravenous within the past 1 month;",
            "criterions": [
                {
                    "exact_snippets": "history of using broad-spectrum antibiotics ... within the past 1 month",
                    "criterion": "broad-spectrum antibiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                },
                {
                    "exact_snippets": "history of using ... probiotics by oral or intravenous within the past 1 month",
                    "criterion": "probiotics usage",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 1 month"
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Received routine immunosuppressive drugs for the past 6 months;",
            "criterions": [
                {
                    "exact_snippets": "Received routine immunosuppressive drugs for the past 6 months",
                    "criterion": "immunosuppressive drug use",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Unable or unwilling to cooperate with follow-up and related examinations;",
            "criterions": [
                {
                    "exact_snippets": "Unable or unwilling to cooperate with follow-up and related examinations",
                    "criterion": "cooperation with follow-up and related examinations",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Patients who can not eat normally or need to rely on medicine or enema and other defecation;",
            "criterions": [
                {
                    "exact_snippets": "Patients who can not eat normally",
                    "criterion": "ability to eat normally",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "need to rely on medicine or enema and other defecation",
                    "criterion": "reliance on medicine or enema for defecation",
                    "requirements": [
                        {
                            "requirement_type": "reliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. With mental illness or any other serious cardiovascular disease;",
            "criterions": [
                {
                    "exact_snippets": "mental illness",
                    "criterion": "mental illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "serious cardiovascular disease",
                    "criterion": "cardiovascular disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. With pregnant or lactating or planning to become pregnant within one year;",
            "criterions": [
                {
                    "exact_snippets": "pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "planning to become pregnant within one year",
                    "criterion": "pregnancy planning",
                    "requirements": [
                        {
                            "requirement_type": "timeframe",
                            "expected_value": "within one year"
                        }
                    ]
                }
            ]
        },
        {
            "line": "10. Currently participating in, or receiving, an interventional clinical study that affects patients' treatment decisions.",
            "criterions": [
                {
                    "exact_snippets": "Currently participating in, or receiving, an interventional clinical study",
                    "criterion": "participation in interventional clinical study",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "affects patients' treatment decisions",
                    "criterion": "effect on treatment decisions",
                    "requirements": [
                        {
                            "requirement_type": "impact",
                            "expected_value": "affects treatment decisions"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Except baseline exclusion criteria, and the following conditions should be excluded:",
            "criterions": [
                {
                    "exact_snippets": "baseline exclusion criteria",
                    "criterion": "baseline exclusion criteria",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "the following conditions should be excluded",
                    "criterion": "specific conditions",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. Diagnosed as advanced colorectal cancer (with or without surgery, radiation, chemotherapy, targeted therapy, immunotherapy);",
            "criterions": [
                {
                    "exact_snippets": "Diagnosed as advanced colorectal cancer",
                    "criterion": "advanced colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without surgery",
                    "criterion": "surgery",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without ... radiation",
                    "criterion": "radiation",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without ... chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without ... targeted therapy",
                    "criterion": "targeted therapy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without ... immunotherapy",
                    "criterion": "immunotherapy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Refuse to sign the informed consent.",
            "criterions": [
                {
                    "exact_snippets": "Refuse to sign the informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* Inclusion Criteria（Sporadic early colorectal cancer group）：",
            "criterions": []
        },
        {
            "line": "<!-- -->",
            "criterions": []
        }
    ],
    "failed_exclusion": [
        {
            "line": "* -Exclusion Criteria（Healthy control group）：",
            "criterions": []
        },
        {
            "line": "* Exclusion Criteria（Sporadic colorectal adenoma group）：",
            "criterions": []
        },
        {
            "line": "* Exclusion Criteria（Sporadic early colorectal cancer group）：",
            "criterions": []
        },
        {
            "line": "* Exclusion Criteria（Cohort study）",
            "criterions": []
        }
    ],
    "failed_miscellaneous": []
}