{
    "info": {
        "nct_id": "NCT04632173",
        "official_title": "HERODOTUS: Head and Neck cancERs International cOviD-19 collabOraTion",
        "inclusion_criteria": "Any head and neck cancer patients (including salivary gland, thyroid, nasal and paranasal cancer with a COVID-19 diagnosis defined as any of the following:\n\n* Laboratory confirmed [Real Time - Polymerase Chain Reaction (RT-PCR) technique] COVID-19.\n* Suspected COVID-19 cases; diagnosed clinically based on symptoms (fever >37.5°, decrease of oximeter saturation of at least 5 %, cough, diarrhoea, otitis, dysgeusia, anosmia, myalgia, arthralgia, conjunctivitis and rhinorrhea and exposure to confirmed COVID-19 positive case (laboratory confirmation).\n* Clinically diagnosed cases; suspected cases with lung imaging features consistent with coronavirus pneumonia.\n* Asymptomatic cases; diagnosed based on positive viral nucleic acid test results but without any COVID- 19 symptoms\nMust have minimum age of 18 Years\nMust have maximum age of 100 Years",
        "exclusion_criteria": "-",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "Any head and neck cancer patients (including salivary gland, thyroid, nasal and paranasal cancer with a COVID-19 diagnosis defined as any of the following:",
            "criterions": [
                {
                    "exact_snippets": "head and neck cancer patients",
                    "criterion": "head and neck cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "salivary gland",
                    "criterion": "salivary gland cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "thyroid",
                    "criterion": "thyroid cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "nasal and paranasal cancer",
                    "criterion": "nasal and paranasal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "COVID-19 diagnosis",
                    "criterion": "COVID-19 diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Laboratory confirmed [Real Time - Polymerase Chain Reaction (RT-PCR) technique] COVID-19.",
            "criterions": [
                {
                    "exact_snippets": "Laboratory confirmed [Real Time - Polymerase Chain Reaction (RT-PCR) technique] COVID-19.",
                    "criterion": "COVID-19",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "RT-PCR"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Suspected COVID-19 cases; diagnosed clinically based on symptoms (fever >37.5°, decrease of oximeter saturation of at least 5 %, cough, diarrhoea, otitis, dysgeusia, anosmia, myalgia, arthralgia, conjunctivitis and rhinorrhea and exposure to confirmed COVID-19 positive case (laboratory confirmation).",
            "criterions": [
                {
                    "exact_snippets": "Suspected COVID-19 cases",
                    "criterion": "COVID-19 suspicion",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosed clinically based on symptoms",
                    "criterion": "clinical diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "symptoms"
                        }
                    ]
                },
                {
                    "exact_snippets": "fever >37.5°",
                    "criterion": "fever",
                    "requirements": [
                        {
                            "requirement_type": "temperature",
                            "expected_value": {
                                "operator": ">",
                                "value": 37.5,
                                "unit": "°"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "decrease of oximeter saturation of at least 5 %",
                    "criterion": "oximeter saturation",
                    "requirements": [
                        {
                            "requirement_type": "decrease",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "%"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "cough",
                    "criterion": "cough",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "diarrhoea",
                    "criterion": "diarrhoea",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "otitis",
                    "criterion": "otitis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "dysgeusia",
                    "criterion": "dysgeusia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "anosmia",
                    "criterion": "anosmia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "myalgia",
                    "criterion": "myalgia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "arthralgia",
                    "criterion": "arthralgia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "conjunctivitis",
                    "criterion": "conjunctivitis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "rhinorrhea",
                    "criterion": "rhinorrhea",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "exposure to confirmed COVID-19 positive case (laboratory confirmation)",
                    "criterion": "exposure to confirmed COVID-19 case",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "laboratory"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinically diagnosed cases; suspected cases with lung imaging features consistent with coronavirus pneumonia.",
            "criterions": [
                {
                    "exact_snippets": "Clinically diagnosed cases",
                    "criterion": "clinical diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "suspected cases with lung imaging features consistent with coronavirus pneumonia",
                    "criterion": "lung imaging features",
                    "requirements": [
                        {
                            "requirement_type": "consistency with coronavirus pneumonia",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Asymptomatic cases; diagnosed based on positive viral nucleic acid test results but without any COVID- 19 symptoms",
            "criterions": [
                {
                    "exact_snippets": "Asymptomatic cases",
                    "criterion": "symptoms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "positive viral nucleic acid test results",
                    "criterion": "viral nucleic acid test",
                    "requirements": [
                        {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 100 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 100 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 100,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "-",
            "criterions": []
        }
    ],
    "failed_miscellaneous": []
}