{
    "info": {
        "nct_id": "NCT04397276",
        "official_title": "A Phase 1 Study of JNJ-70218902, a T Cell Redirecting Agent, in Advanced Stage Solid Tumors",
        "inclusion_criteria": "* Histology: Metastatic castration-resistant prostate cancer (mCRPC) with histologic confirmation of adenocarcinoma. Adenocarcinoma with small-cell or neuroendocrine features is allowed\n* Measurable or evaluable disease\n* Prior treatment with at least 1 prior novel androgen receptor (AR)-targeted therapy or chemotherapy\n* If the participant is receiving treatment with gonadotropin-releasing hormone agonists or antagonist analogs (GnRH), this therapy must have been initiated prior to first dose of study drug and must be continued throughout the study\n* Eastern Cooperative Oncology Group (ECOG) performance status grade of 0 or 1\n* Adequate organs functions\nHealthy volunteers allowed\nMust be MALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Known brain metastases\n* Concurrent use of any other anticancer treatment or investigational agent for the treatment of advanced disease\n* Toxicities related to prior anticancer treatments have not returned to Grade less than or equal to (<=) 1 or baseline, except for alopecia and vitiligo\n* Solid organ or bone marrow transplantation\n* Known allergies, hypersensitivity, or intolerance to JNJ-70218902 or its excipients\n* Certain comorbidities",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Histology: Metastatic castration-resistant prostate cancer (mCRPC) with histologic confirmation of adenocarcinoma. Adenocarcinoma with small-cell or neuroendocrine features is allowed",
            "criterions": [
                {
                    "exact_snippets": "Metastatic castration-resistant prostate cancer (mCRPC)",
                    "criterion": "prostate cancer type",
                    "requirements": [
                        {
                            "requirement_type": "specific type",
                            "expected_value": "metastatic castration-resistant"
                        }
                    ]
                },
                {
                    "exact_snippets": "histologic confirmation of adenocarcinoma",
                    "criterion": "adenocarcinoma",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Adenocarcinoma with small-cell or neuroendocrine features is allowed",
                    "criterion": "adenocarcinoma features",
                    "requirements": [
                        {
                            "requirement_type": "allowed features",
                            "expected_value": [
                                "small-cell",
                                "neuroendocrine"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Measurable or evaluable disease",
            "criterions": [
                {
                    "exact_snippets": "Measurable or evaluable disease",
                    "criterion": "disease",
                    "requirements": [
                        {
                            "requirement_type": "measurability",
                            "expected_value": [
                                "measurable",
                                "evaluable"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior treatment with at least 1 prior novel androgen receptor (AR)-targeted therapy or chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "Prior treatment with at least 1 prior novel androgen receptor (AR)-targeted therapy",
                    "criterion": "novel androgen receptor (AR)-targeted therapy",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Prior treatment with at least 1 prior ... chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* If the participant is receiving treatment with gonadotropin-releasing hormone agonists or antagonist analogs (GnRH), this therapy must have been initiated prior to first dose of study drug and must be continued throughout the study",
            "criterions": [
                {
                    "exact_snippets": "participant is receiving treatment with gonadotropin-releasing hormone agonists or antagonist analogs (GnRH)",
                    "criterion": "GnRH therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "therapy must have been initiated prior to first dose of study drug",
                    "criterion": "GnRH therapy initiation",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "prior to first dose of study drug"
                        }
                    ]
                },
                {
                    "exact_snippets": "therapy ... must be continued throughout the study",
                    "criterion": "GnRH therapy continuation",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": "throughout the study"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Eastern Cooperative Oncology Group (ECOG) performance status grade of 0 or 1",
            "criterions": [
                {
                    "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status grade of 0 or 1",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "grade",
                            "expected_value": [
                                "0",
                                "1"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Adequate organs functions",
            "criterions": [
                {
                    "exact_snippets": "Adequate organs functions",
                    "criterion": "organ functions",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be MALE",
            "criterions": [
                {
                    "exact_snippets": "Must be MALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "male"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Known brain metastases",
            "criterions": [
                {
                    "exact_snippets": "Known brain metastases",
                    "criterion": "brain metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Concurrent use of any other anticancer treatment or investigational agent for the treatment of advanced disease",
            "criterions": [
                {
                    "exact_snippets": "Concurrent use of any other anticancer treatment",
                    "criterion": "concurrent anticancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Concurrent use of any other ... investigational agent for the treatment of advanced disease",
                    "criterion": "concurrent investigational agent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Toxicities related to prior anticancer treatments have not returned to Grade less than or equal to (<=) 1 or baseline, except for alopecia and vitiligo",
            "criterions": [
                {
                    "exact_snippets": "Toxicities related to prior anticancer treatments have not returned to Grade less than or equal to (<=) 1 or baseline",
                    "criterion": "toxicities related to prior anticancer treatments",
                    "requirements": [
                        {
                            "requirement_type": "grade",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "Grade"
                            }
                        },
                        {
                            "requirement_type": "grade",
                            "expected_value": "baseline"
                        }
                    ]
                },
                {
                    "exact_snippets": "except for alopecia",
                    "criterion": "alopecia",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "except for ... vitiligo",
                    "criterion": "vitiligo",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Solid organ or bone marrow transplantation",
            "criterions": [
                {
                    "exact_snippets": "Solid organ or bone marrow transplantation",
                    "criterion": "solid organ transplantation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Solid organ or bone marrow transplantation",
                    "criterion": "bone marrow transplantation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Known allergies, hypersensitivity, or intolerance to JNJ-70218902 or its excipients",
            "criterions": [
                {
                    "exact_snippets": "Known allergies, hypersensitivity, or intolerance to JNJ-70218902",
                    "criterion": "allergies, hypersensitivity, or intolerance",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Known allergies, hypersensitivity, or intolerance ... excipients",
                    "criterion": "allergies, hypersensitivity, or intolerance to excipients",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Certain comorbidities",
            "criterions": [
                {
                    "exact_snippets": "Certain comorbidities",
                    "criterion": "comorbidities",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}