{
    "info": {
        "nct_id": "NCT04353882",
        "official_title": "Evaluation of the Difference in Expression of the Mu Type 1 Opioid Receptor and of the Markers of Its Activation (Cyclic Adenosine Monophosphate and Protein Kinase A) in Colorectal Cancer. Case-control Study in Patients With Tumor Recurrence Versus Disease-free Patients at 5 Years.",
        "inclusion_criteria": "* Patients over 18 years of age.\n* Colorectal surgery scheduled between January 2010 - December 2014.\n* Stage II or III colon or rectum neoplasm (T3 / T4 N + M0).\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Neoplasia of colon or rectum in Stage I or Stage IV.\n* Non-oncological colorectal surgery.\n* Urgent surgery",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patients over 18 years of age.",
            "criterions": [
                {
                    "exact_snippets": "Patients over 18 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Colorectal surgery scheduled between January 2010 - December 2014.",
            "criterions": [
                {
                    "exact_snippets": "Colorectal surgery scheduled between January 2010 - December 2014.",
                    "criterion": "colorectal surgery",
                    "requirements": [
                        {
                            "requirement_type": "scheduled date",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2010,
                                        "unit": "year"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2014,
                                        "unit": "year"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Stage II or III colon or rectum neoplasm (T3 / T4 N + M0).",
            "criterions": [
                {
                    "exact_snippets": "Stage II or III colon or rectum neoplasm",
                    "criterion": "colon or rectum neoplasm",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "II",
                                "III"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "T3 / T4",
                    "criterion": "tumor size",
                    "requirements": [
                        {
                            "requirement_type": "T stage",
                            "expected_value": [
                                "T3",
                                "T4"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "N +",
                    "criterion": "lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "N stage",
                            "expected_value": "N+"
                        }
                    ]
                },
                {
                    "exact_snippets": "M0",
                    "criterion": "distant metastasis",
                    "requirements": [
                        {
                            "requirement_type": "M stage",
                            "expected_value": "M0"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Neoplasia of colon or rectum in Stage I or Stage IV.",
            "criterions": [
                {
                    "exact_snippets": "Neoplasia of colon or rectum",
                    "criterion": "neoplasia",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": [
                                "colon",
                                "rectum"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "Stage I or Stage IV",
                    "criterion": "stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "I",
                                "IV"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Non-oncological colorectal surgery.",
            "criterions": [
                {
                    "exact_snippets": "Non-oncological colorectal surgery",
                    "criterion": "colorectal surgery",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "non-oncological"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Urgent surgery",
            "criterions": [
                {
                    "exact_snippets": "Urgent surgery",
                    "criterion": "surgery",
                    "requirements": [
                        {
                            "requirement_type": "urgency",
                            "expected_value": "urgent"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}