{
    "info": {
        "nct_id": "NCT04227457",
        "official_title": "Prospective Epidemiological Study of Metastatic Non Small Cell Lung Cancer (NSCLC) in Latin America",
        "inclusion_criteria": "1. Patients aged 18 years or older;\n2. Newly diagnosed Non-Small Cell Lung Cancer (NSCLC) during the period of the study (which includes 3 months prior to site activation by LACOG, although they can have received anti-cancer treatment during that time);\n3. Histologically or cytologically confirmed advanced NSCLC:\n\n   1. Stage IIIB that progressed after curative therapy (chemoradiation and/or surgery);\n   2. Stage IV metastatic disease (de novo or distant relapse)\n4. Any NSCLC histological subtype and molecular mutation;\n5. Any Eastern Cooperative Oncology Group (ECOG) Performance Status (0 to 4) at diagnosis;\n6. Patients assigned by treating physician to any therapy (i.e. chemotherapy, targeted agents, immunotherapy) or palliative care;\n7. Access to patient medical chart for data collection;\n8. Willing and able to provide written informed consent and privacy authorization for the release of personal health information.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Patients aged 18 years or older;",
            "criterions": [
                {
                    "exact_snippets": "Patients aged 18 years or older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Newly diagnosed Non-Small Cell Lung Cancer (NSCLC) during the period of the study (which includes 3 months prior to site activation by LACOG, although they can have received anti-cancer treatment during that time);",
            "criterions": [
                {
                    "exact_snippets": "Newly diagnosed Non-Small Cell Lung Cancer (NSCLC)",
                    "criterion": "Non-Small Cell Lung Cancer (NSCLC)",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis status",
                            "expected_value": "newly diagnosed"
                        }
                    ]
                },
                {
                    "exact_snippets": "during the period of the study (which includes 3 months prior to site activation by LACOG",
                    "criterion": "diagnosis timing",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "during the period of the study (which includes 3 months prior to site activation by LACOG"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Histologically or cytologically confirmed advanced NSCLC:",
            "criterions": [
                {
                    "exact_snippets": "Histologically or cytologically confirmed",
                    "criterion": "NSCLC confirmation method",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "advanced NSCLC",
                    "criterion": "NSCLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    ]
                }
            ]
        },
        {
            "line": "1. Stage IIIB that progressed after curative therapy (chemoradiation and/or surgery);",
            "criterions": [
                {
                    "exact_snippets": "Stage IIIB",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IIIB"
                        }
                    ]
                },
                {
                    "exact_snippets": "progressed after curative therapy",
                    "criterion": "disease progression",
                    "requirements": [
                        {
                            "requirement_type": "progression status",
                            "expected_value": "progressed"
                        }
                    ]
                },
                {
                    "exact_snippets": "curative therapy (chemoradiation and/or surgery)",
                    "criterion": "prior treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "chemoradiation",
                                "surgery"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Stage IV metastatic disease (de novo or distant relapse)",
            "criterions": [
                {
                    "exact_snippets": "Stage IV metastatic disease",
                    "criterion": "metastatic disease",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    ]
                },
                {
                    "exact_snippets": "de novo or distant relapse",
                    "criterion": "metastatic disease",
                    "requirements": [
                        {
                            "requirement_type": "origin",
                            "expected_value": [
                                "de novo",
                                "distant relapse"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Any NSCLC histological subtype and molecular mutation;",
            "criterions": [
                {
                    "exact_snippets": "NSCLC histological subtype",
                    "criterion": "NSCLC histological subtype",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "molecular mutation",
                    "criterion": "molecular mutation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Any Eastern Cooperative Oncology Group (ECOG) Performance Status (0 to 4) at diagnosis;",
            "criterions": [
                {
                    "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) Performance Status (0 to 4)",
                    "criterion": "ECOG Performance Status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Patients assigned by treating physician to any therapy (i.e. chemotherapy, targeted agents, immunotherapy) or palliative care;",
            "criterions": [
                {
                    "exact_snippets": "Patients assigned by treating physician to any therapy (i.e. chemotherapy, targeted agents, immunotherapy)",
                    "criterion": "therapy assignment",
                    "requirements": [
                        {
                            "requirement_type": "assignment",
                            "expected_value": [
                                "chemotherapy",
                                "targeted agents",
                                "immunotherapy"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "Patients assigned by treating physician to ... palliative care",
                    "criterion": "palliative care assignment",
                    "requirements": [
                        {
                            "requirement_type": "assignment",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Access to patient medical chart for data collection;",
            "criterions": [
                {
                    "exact_snippets": "Access to patient medical chart",
                    "criterion": "access to patient medical chart",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Willing and able to provide written informed consent and privacy authorization for the release of personal health information.",
            "criterions": [
                {
                    "exact_snippets": "Willing and able to provide written informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "privacy authorization for the release of personal health information",
                    "criterion": "privacy authorization",
                    "requirements": [
                        {
                            "requirement_type": "authorization",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}