{
    "info": {
        "nct_id": "NCT04116827",
        "official_title": "Analysis of Sleep and Activity Patterns in Pre-menopausal Breast Cancer Patients After Taking Tamoxifen Using a Wrist-worn Internet of Things Device",
        "inclusion_criteria": "* diagnosed of unilateral breast cancer (stage 0 ~III)\n* underwent proper cancer treatment including surgery, chemotherapy, radiation therapy\n* age : 18 ~ 45\n* scheduled for applying tamoxifen and goserelin\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 45 Years",
        "exclusion_criteria": "* need CPAP device during sleep due to sleep apnea\n* under medication for restless leg syndrome\n* previous history of tamoxifen\n* irregular bedtime due to shift work\n* diagnosed of recurrent or metastatic cancer\n* have difficulty understanding and conducting surveys and verbal instructions due to severe cognitive, communication and perception problems\n* refuse to participate\n* has musculoskeletal system and neurological damage and lesions",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* diagnosed of unilateral breast cancer (stage 0 ~III)",
            "criterions": [
                {
                    "exact_snippets": "diagnosed of unilateral breast cancer",
                    "criterion": "unilateral breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "stage 0 ~III",
                    "criterion": "breast cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* underwent proper cancer treatment including surgery, chemotherapy, radiation therapy",
            "criterions": [
                {
                    "exact_snippets": "underwent proper cancer treatment including surgery",
                    "criterion": "cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "surgery"
                        }
                    ]
                },
                {
                    "exact_snippets": "underwent proper cancer treatment including ... chemotherapy",
                    "criterion": "cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "chemotherapy"
                        }
                    ]
                },
                {
                    "exact_snippets": "underwent proper cancer treatment including ... radiation therapy",
                    "criterion": "cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "radiation therapy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* age : 18 ~ 45",
            "criterions": [
                {
                    "exact_snippets": "age : 18 ~ 45",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 45,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* scheduled for applying tamoxifen and goserelin",
            "criterions": [
                {
                    "exact_snippets": "scheduled for applying tamoxifen",
                    "criterion": "tamoxifen treatment",
                    "requirements": [
                        {
                            "requirement_type": "scheduled",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "scheduled for applying ... goserelin",
                    "criterion": "goserelin treatment",
                    "requirements": [
                        {
                            "requirement_type": "scheduled",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 45 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 45 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 45,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* need CPAP device during sleep due to sleep apnea",
            "criterions": [
                {
                    "exact_snippets": "need CPAP device during sleep",
                    "criterion": "CPAP device usage",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "due to sleep apnea",
                    "criterion": "sleep apnea",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* under medication for restless leg syndrome",
            "criterions": [
                {
                    "exact_snippets": "under medication for restless leg syndrome",
                    "criterion": "restless leg syndrome",
                    "requirements": [
                        {
                            "requirement_type": "medication status",
                            "expected_value": "under medication"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* previous history of tamoxifen",
            "criterions": [
                {
                    "exact_snippets": "previous history of tamoxifen",
                    "criterion": "tamoxifen",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* irregular bedtime due to shift work",
            "criterions": [
                {
                    "exact_snippets": "irregular bedtime due to shift work",
                    "criterion": "bedtime regularity",
                    "requirements": [
                        {
                            "requirement_type": "cause",
                            "expected_value": "shift work"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* diagnosed of recurrent or metastatic cancer",
            "criterions": [
                {
                    "exact_snippets": "diagnosed of recurrent or metastatic cancer",
                    "criterion": "cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": [
                                "recurrent",
                                "metastatic"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* have difficulty understanding and conducting surveys and verbal instructions due to severe cognitive, communication and perception problems",
            "criterions": [
                {
                    "exact_snippets": "difficulty understanding and conducting surveys and verbal instructions",
                    "criterion": "understanding and conducting surveys and verbal instructions",
                    "requirements": [
                        {
                            "requirement_type": "difficulty",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "severe cognitive, communication and perception problems",
                    "criterion": "cognitive, communication and perception problems",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* refuse to participate",
            "criterions": [
                {
                    "exact_snippets": "refuse to participate",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* has musculoskeletal system and neurological damage and lesions",
            "criterions": [
                {
                    "exact_snippets": "musculoskeletal system",
                    "criterion": "musculoskeletal system",
                    "requirements": [
                        {
                            "requirement_type": "damage",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "neurological damage",
                    "criterion": "neurological system",
                    "requirements": [
                        {
                            "requirement_type": "damage",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "lesions",
                    "criterion": "lesions",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}