{
    "info": {
        "nct_id": "NCT04101760",
        "official_title": "Long-acting Versus Short-acting Granulocyte Colony Stimulating Factor for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer Patients: A Multicenter Phase 3 Randomized Controlled Study",
        "inclusion_criteria": "* With definitive pathological results of epithelial ovarian cancer\n* With an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2\n* Aged 18 or older\n* Receiving 3-4 weeks per cycle of platinum-based chemotherapy with or without debulking surgery\n* Regularly followed up in the study centers\n* Provided consent for participation.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Failure to meet all the inclusion criteria\n* Non-compliance with the study protocols\n* With a history of chemotherapy or pelvic radiotherapy for malignancies\n* Presence of immunosuppressive diseases such as organ transplantation or acquired immune deficiency syndrome\n* Treated with weekly chemotherapy regimens\n* Presence of hematological disorders",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* With definitive pathological results of epithelial ovarian cancer",
            "criterions": [
                {
                    "exact_snippets": "definitive pathological results of epithelial ovarian cancer",
                    "criterion": "epithelial ovarian cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis confirmation",
                            "expected_value": "definitive pathological results"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* With an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2",
            "criterions": [
                {
                    "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2",
                    "criterion": "ECOG performance status score",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Aged 18 or older",
            "criterions": [
                {
                    "exact_snippets": "Aged 18 or older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Receiving 3-4 weeks per cycle of platinum-based chemotherapy with or without debulking surgery",
            "criterions": [
                {
                    "exact_snippets": "Receiving 3-4 weeks per cycle of platinum-based chemotherapy",
                    "criterion": "platinum-based chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "treatment duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 3,
                                        "unit": "weeks"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without debulking surgery",
                    "criterion": "debulking surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "with",
                                "without"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Regularly followed up in the study centers",
            "criterions": [
                {
                    "exact_snippets": "Regularly followed up in the study centers",
                    "criterion": "follow-up",
                    "requirements": [
                        {
                            "requirement_type": "frequency",
                            "expected_value": "regularly"
                        },
                        {
                            "requirement_type": "location",
                            "expected_value": "study centers"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Provided consent for participation.",
            "criterions": [
                {
                    "exact_snippets": "Provided consent for participation.",
                    "criterion": "consent for participation",
                    "requirements": [
                        {
                            "requirement_type": "provision",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Failure to meet all the inclusion criteria",
            "criterions": [
                {
                    "exact_snippets": "Failure to meet all the inclusion criteria",
                    "criterion": "inclusion criteria",
                    "requirements": [
                        {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Non-compliance with the study protocols",
            "criterions": [
                {
                    "exact_snippets": "Non-compliance with the study protocols",
                    "criterion": "compliance with study protocols",
                    "requirements": [
                        {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* With a history of chemotherapy or pelvic radiotherapy for malignancies",
            "criterions": [
                {
                    "exact_snippets": "history of chemotherapy",
                    "criterion": "chemotherapy history",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of ... pelvic radiotherapy",
                    "criterion": "pelvic radiotherapy history",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Presence of immunosuppressive diseases such as organ transplantation or acquired immune deficiency syndrome",
            "criterions": [
                {
                    "exact_snippets": "Presence of immunosuppressive diseases such as organ transplantation",
                    "criterion": "immunosuppressive diseases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Presence of ... acquired immune deficiency syndrome",
                    "criterion": "acquired immune deficiency syndrome",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Treated with weekly chemotherapy regimens",
            "criterions": [
                {
                    "exact_snippets": "Treated with weekly chemotherapy regimens",
                    "criterion": "chemotherapy regimen",
                    "requirements": [
                        {
                            "requirement_type": "frequency",
                            "expected_value": "weekly"
                        },
                        {
                            "requirement_type": "treatment status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Presence of hematological disorders",
            "criterions": [
                {
                    "exact_snippets": "Presence of hematological disorders",
                    "criterion": "hematological disorders",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}