{
    "info": {
        "nct_id": "NCT04074460",
        "official_title": "Volatile Anaesthesia and Perioperative Outcomes Related to Cancer (VAPOR-C): A Feasibility Study",
        "inclusion_criteria": "* Male or female\n* Age 18-80 years\n* Elective surgery\n* Major cancer surgery expecting to last two or more hours, for:\n* Breast (mastectomy or segmentectomy plus sentinel node dissection)\n* Colorectal\n* Lung\n* Prostate\n* Melanoma (excision of melanoma plus lymph node dissection AND/OR skin flap construction\n* Other major cancer surgeries (e.g. oesophagectomy, head and neck cancer, etc.)\n\nExclusion Criteria\n\n* Palliative surgery for end-stage disease with no curative intent\n* Emergency surgery\n* Extensive comorbid disease, i.e. American Society of Anesthesiologists (ASA) Score > 4\n* Age <18 or >80 years old\n* Refusal or inability to provide valid informed consent\n* Risk of severe postoperative nausea and vomiting (PONV risk score >3)\n* Previous allergy or contraindication to either anaesthetic medication\n* Indication for gas induction of anaesthesia\n* Currently enrolled in another clinical trial unless agreed by the coordinating principal investigator and site principal investigator that co-enrolment can occur.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Male or female",
            "criterions": [
                {
                    "exact_snippets": "Male or female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age 18-80 years",
            "criterions": [
                {
                    "exact_snippets": "Age 18-80 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Elective surgery",
            "criterions": [
                {
                    "exact_snippets": "Elective surgery",
                    "criterion": "elective surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Major cancer surgery expecting to last two or more hours, for:",
            "criterions": [
                {
                    "exact_snippets": "Major cancer surgery expecting to last two or more hours",
                    "criterion": "cancer surgery duration",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "hours"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Breast (mastectomy or segmentectomy plus sentinel node dissection)",
            "criterions": [
                {
                    "exact_snippets": "Breast (mastectomy or segmentectomy plus sentinel node dissection)",
                    "criterion": "breast surgery",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "mastectomy",
                                "segmentectomy"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "Breast (mastectomy or segmentectomy plus sentinel node dissection)",
                    "criterion": "sentinel node dissection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Colorectal",
            "criterions": [
                {
                    "exact_snippets": "Colorectal",
                    "criterion": "colorectal cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Lung",
            "criterions": [
                {
                    "exact_snippets": "Lung",
                    "criterion": "lung",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prostate",
            "criterions": [
                {
                    "exact_snippets": "Prostate",
                    "criterion": "prostate",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Melanoma (excision of melanoma plus lymph node dissection AND/OR skin flap construction",
            "criterions": [
                {
                    "exact_snippets": "Melanoma",
                    "criterion": "melanoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "excision of melanoma",
                    "criterion": "melanoma excision",
                    "requirements": [
                        {
                            "requirement_type": "procedure",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "lymph node dissection",
                    "criterion": "lymph node dissection",
                    "requirements": [
                        {
                            "requirement_type": "procedure",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "skin flap construction",
                    "criterion": "skin flap construction",
                    "requirements": [
                        {
                            "requirement_type": "procedure",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Other major cancer surgeries (e.g. oesophagectomy, head and neck cancer, etc.)",
            "criterions": [
                {
                    "exact_snippets": "Other major cancer surgeries (e.g. oesophagectomy, head and neck cancer, etc.)",
                    "criterion": "major cancer surgeries",
                    "requirements": [
                        {
                            "requirement_type": "examples",
                            "expected_value": [
                                "oesophagectomy",
                                "head and neck cancer"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Palliative surgery for end-stage disease with no curative intent",
            "criterions": [
                {
                    "exact_snippets": "Palliative surgery",
                    "criterion": "surgery type",
                    "requirements": [
                        {
                            "requirement_type": "intent",
                            "expected_value": "palliative"
                        }
                    ]
                },
                {
                    "exact_snippets": "end-stage disease",
                    "criterion": "disease stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "end-stage"
                        }
                    ]
                },
                {
                    "exact_snippets": "no curative intent",
                    "criterion": "treatment intent",
                    "requirements": [
                        {
                            "requirement_type": "intent",
                            "expected_value": "non-curative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Emergency surgery",
            "criterions": [
                {
                    "exact_snippets": "Emergency surgery",
                    "criterion": "emergency surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Extensive comorbid disease, i.e. American Society of Anesthesiologists (ASA) Score > 4",
            "criterions": [
                {
                    "exact_snippets": "Extensive comorbid disease",
                    "criterion": "comorbid disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "extensive"
                        }
                    ]
                },
                {
                    "exact_snippets": "American Society of Anesthesiologists (ASA) Score > 4",
                    "criterion": "ASA Score",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Age <18 or >80 years old",
            "criterions": [
                {
                    "exact_snippets": "Age <18 or >80 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": ">",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Refusal or inability to provide valid informed consent",
            "criterions": [
                {
                    "exact_snippets": "Refusal ... to provide valid informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "inability to provide valid informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Risk of severe postoperative nausea and vomiting (PONV risk score >3)",
            "criterions": [
                {
                    "exact_snippets": "Risk of severe postoperative nausea and vomiting (PONV risk score >3)",
                    "criterion": "PONV risk score",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Previous allergy or contraindication to either anaesthetic medication",
            "criterions": [
                {
                    "exact_snippets": "Previous allergy ... to either anaesthetic medication",
                    "criterion": "allergy to anaesthetic medication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "contraindication to either anaesthetic medication",
                    "criterion": "contraindication to anaesthetic medication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Indication for gas induction of anaesthesia",
            "criterions": [
                {
                    "exact_snippets": "Indication for gas induction of anaesthesia",
                    "criterion": "indication for gas induction of anaesthesia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Currently enrolled in another clinical trial unless agreed by the coordinating principal investigator and site principal investigator that co-enrolment can occur.",
            "criterions": [
                {
                    "exact_snippets": "Currently enrolled in another clinical trial",
                    "criterion": "enrollment in another clinical trial",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "Exclusion Criteria",
            "criterions": []
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}