{
    "info": {
        "nct_id": "NCT03843229",
        "official_title": "Clinical Trial of Cinobufacini Combined With Transarterial Chemoembolization (TACE) on Primary Liver Cancer",
        "inclusion_criteria": "* Age:18-70 years.\n* male and female.\n* signed the informed consent form.\n* Diagnosis:Primary liver cancer diagnosed by imaging、cell and pathology report.\n* Eastern Cooperative Oncology Group (ECOG) :0-2;life expectancy more than 3 months.\n* Indication for TACE,no contraindication.\n* First time chemotherapy or at least 6 months after last chemotherapy and radiotherapy.\n* At least 8 weeks after last biotherapy.\n* Surgery：had not received transplantation surgery,at least 2 weeks after last major surgery.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "* Chemotherapy is contraindicated.\n* Have the primary disease can cause the neuropathy.\n* A history of other malignant tumor in recent 5 years.\n* Less than 6 months after last chemotherapy or radiotherapy.\n* Less than 8 months after last.\n* Cinobufacini allergy.\n* Had received transplantation surgery ,less than 2 weeks after last major surgery.\n* Other researchers think is not suitable for this clinical trail.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age:18-70 years.",
            "criterions": [
                {
                    "exact_snippets": "Age:18-70 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* male and female.",
            "criterions": [
                {
                    "exact_snippets": "male and female",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "allowed_values",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* signed the informed consent form.",
            "criterions": [
                {
                    "exact_snippets": "signed the informed consent form",
                    "criterion": "informed consent form",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Diagnosis:Primary liver cancer diagnosed by imaging、cell and pathology report.",
            "criterions": [
                {
                    "exact_snippets": "Primary liver cancer diagnosed by imaging",
                    "criterion": "primary liver cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis method",
                            "expected_value": "imaging"
                        }
                    ]
                },
                {
                    "exact_snippets": "Primary liver cancer diagnosed by ... cell",
                    "criterion": "primary liver cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis method",
                            "expected_value": "cell"
                        }
                    ]
                },
                {
                    "exact_snippets": "Primary liver cancer diagnosed by ... pathology report",
                    "criterion": "primary liver cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis method",
                            "expected_value": "pathology report"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Eastern Cooperative Oncology Group (ECOG) :0-2;life expectancy more than 3 months.",
            "criterions": [
                {
                    "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) :0-2",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "life expectancy more than 3 months",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Indication for TACE,no contraindication.",
            "criterions": [
                {
                    "exact_snippets": "Indication for TACE",
                    "criterion": "TACE indication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "no contraindication",
                    "criterion": "contraindication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* First time chemotherapy or at least 6 months after last chemotherapy and radiotherapy.",
            "criterions": [
                {
                    "exact_snippets": "First time chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": "first time"
                        }
                    ]
                },
                {
                    "exact_snippets": "at least 6 months after last chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "at least 6 months after last ... radiotherapy",
                    "criterion": "radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* At least 8 weeks after last biotherapy.",
            "criterions": [
                {
                    "exact_snippets": "At least 8 weeks after last biotherapy.",
                    "criterion": "time since last biotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Surgery：had not received transplantation surgery,at least 2 weeks after last major surgery.",
            "criterions": [
                {
                    "exact_snippets": "had not received transplantation surgery",
                    "criterion": "transplantation surgery",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "at least 2 weeks after last major surgery",
                    "criterion": "time since last major surgery",
                    "requirements": [
                        {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Chemotherapy is contraindicated.",
            "criterions": [
                {
                    "exact_snippets": "Chemotherapy is contraindicated.",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "contraindication",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Have the primary disease can cause the neuropathy.",
            "criterions": [
                {
                    "exact_snippets": "primary disease can cause the neuropathy",
                    "criterion": "primary disease",
                    "requirements": [
                        {
                            "requirement_type": "capability",
                            "expected_value": "can cause neuropathy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A history of other malignant tumor in recent 5 years.",
            "criterions": [
                {
                    "exact_snippets": "A history of other malignant tumor in recent 5 years.",
                    "criterion": "history of other malignant tumor",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Less than 6 months after last chemotherapy or radiotherapy.",
            "criterions": [
                {
                    "exact_snippets": "Less than 6 months after last chemotherapy",
                    "criterion": "time since last chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Less than 6 months after last ... radiotherapy",
                    "criterion": "time since last radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Less than 8 months after last.",
            "criterions": [
                {
                    "exact_snippets": "Less than 8 months after last.",
                    "criterion": "time since last event",
                    "requirements": [
                        {
                            "requirement_type": "time",
                            "expected_value": {
                                "operator": "<",
                                "value": 8,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Cinobufacini allergy.",
            "criterions": [
                {
                    "exact_snippets": "Cinobufacini allergy",
                    "criterion": "Cinobufacini allergy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Had received transplantation surgery ,less than 2 weeks after last major surgery.",
            "criterions": [
                {
                    "exact_snippets": "Had received transplantation surgery",
                    "criterion": "transplantation surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "less than 2 weeks after last major surgery",
                    "criterion": "time since last major surgery",
                    "requirements": [
                        {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Other researchers think is not suitable for this clinical trail.",
            "criterions": [
                {
                    "exact_snippets": "Other researchers think is not suitable",
                    "criterion": "suitability according to other researchers",
                    "requirements": [
                        {
                            "requirement_type": "opinion",
                            "expected_value": "suitable"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}