{
    "info": {
        "nct_id": "NCT03447431",
        "official_title": "Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact (MICROSPLICOTHER)",
        "inclusion_criteria": "* All patients presenting a MSI CRC (second or third state, histologically confirmed) who have been operated at Saint Antoine Hospital between 1998 and 2013\n* Clinical data of patients follow-up available on site\n* non-opposition for tumour samples using from patient obtained\nHealthy volunteers allowed",
        "exclusion_criteria": "* non-opposition for tumour samples using from patient not obtained",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* All patients presenting a MSI CRC (second or third state, histologically confirmed) who have been operated at Saint Antoine Hospital between 1998 and 2013",
            "criterions": [
                {
                    "exact_snippets": "MSI CRC",
                    "criterion": "MSI CRC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "second or third state",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "second",
                                "third"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "histologically confirmed",
                    "criterion": "histological confirmation",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "operated at Saint Antoine Hospital",
                    "criterion": "surgery location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "Saint Antoine Hospital"
                        }
                    ]
                },
                {
                    "exact_snippets": "between 1998 and 2013",
                    "criterion": "surgery date",
                    "requirements": [
                        {
                            "requirement_type": "date range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1998,
                                        "unit": "year"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2013,
                                        "unit": "year"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical data of patients follow-up available on site",
            "criterions": [
                {
                    "exact_snippets": "Clinical data of patients follow-up available on site",
                    "criterion": "clinical data follow-up",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "location",
                            "expected_value": "on site"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* non-opposition for tumour samples using from patient obtained",
            "criterions": [
                {
                    "exact_snippets": "non-opposition for tumour samples using from patient obtained",
                    "criterion": "tumor sample usage consent",
                    "requirements": [
                        {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* non-opposition for tumour samples using from patient not obtained",
            "criterions": [
                {
                    "exact_snippets": "non-opposition for tumour samples using from patient not obtained",
                    "criterion": "tumour sample usage",
                    "requirements": [
                        {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}