{
    "info": {
        "nct_id": "NCT03407001",
        "official_title": "Lesion Detection in Cirrhotic Patients With Contrast Enhanced Ultrasound and the Accuracy of Contrast Enhanced Ultrasound Li-RADS for Hepatocellular Carcinoma Diagnosis",
        "inclusion_criteria": "* Able and willing to provide written informed consent\n* Diagnosis of cirrhosis based on one or more of the following: histology, US, computed tomography (CT) or MRI showing cirrhosis, +/- lesions seen on CE-MRI\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* History of hypersensitivity to sulfur hexafluoride lipid microsphere components or to any of the inactive ingredients in Lumason\n* Pregnant patients-excluded by history\n* Pediatric patients, as pediatric cirrhosis is uncommon",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Able and willing to provide written informed consent",
            "criterions": [
                {
                    "exact_snippets": "Able and willing to provide written informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Diagnosis of cirrhosis based on one or more of the following: histology, US, computed tomography (CT) or MRI showing cirrhosis, +/- lesions seen on CE-MRI",
            "criterions": [
                {
                    "exact_snippets": "Diagnosis of cirrhosis based on one or more of the following: histology",
                    "criterion": "cirrhosis diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "histology"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of cirrhosis based on one or more of the following: ... US",
                    "criterion": "cirrhosis diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "US"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of cirrhosis based on one or more of the following: ... computed tomography (CT)",
                    "criterion": "cirrhosis diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "computed tomography (CT)"
                        }
                    ]
                },
                {
                    "exact_snippets": "Diagnosis of cirrhosis based on one or more of the following: ... MRI showing cirrhosis",
                    "criterion": "cirrhosis diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "MRI"
                        }
                    ]
                },
                {
                    "exact_snippets": "+/- lesions seen on CE-MRI",
                    "criterion": "lesions on CE-MRI",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": "optional"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* History of hypersensitivity to sulfur hexafluoride lipid microsphere components or to any of the inactive ingredients in Lumason",
            "criterions": [
                {
                    "exact_snippets": "History of hypersensitivity to sulfur hexafluoride lipid microsphere components",
                    "criterion": "hypersensitivity to sulfur hexafluoride lipid microsphere components",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "History of hypersensitivity ... to any of the inactive ingredients in Lumason",
                    "criterion": "hypersensitivity to inactive ingredients in Lumason",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant patients-excluded by history",
            "criterions": [
                {
                    "exact_snippets": "Pregnant patients-excluded by history",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pediatric patients, as pediatric cirrhosis is uncommon",
            "criterions": [
                {
                    "exact_snippets": "Pediatric patients",
                    "criterion": "age group",
                    "requirements": [
                        {
                            "requirement_type": "category",
                            "expected_value": "pediatric"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}