{
    "info": {
        "nct_id": "NCT03167372",
        "official_title": "Comparison of N-of-1 Trials of Light Therapy for Depressive Symptoms in Cancer Survivors",
        "inclusion_criteria": "* History of cancer (not including basal cell or squamous cell carcinoma, or carcinoma in situ)\n* Current mild to moderate severity depressive symptoms (PHQ-8 score 5 to 19)\n* iPhone user\nHealthy volunteers allowed\nMust have minimum age of 21 Years",
        "exclusion_criteria": "* Has not completed primary cancer treatment including initial chemotherapy, surgical resection, or radiation therapy\n* Non-English speaking\n* Severe depression (PHQ-8 score >=20) or active suicidal ideations\n* Other severe mental illness that would preclude participation in a study that requires extensive self-monitoring, including depression with psychotic features, other psychotic disorder, bipolar disorder, severe personality disorder\n* <6 months life expectancy due to cancer or other severe medical illness\n* Other severe medical illness that would preclude ability to do daily self-tracking\n* Unavailable for follow-up over the course of the 3 month trial",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* History of cancer (not including basal cell or squamous cell carcinoma, or carcinoma in situ)",
            "criterions": [
                {
                    "exact_snippets": "History of cancer (not including basal cell or squamous cell carcinoma, or carcinoma in situ)",
                    "criterion": "history of cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        },
                        {
                            "requirement_type": "exclusion",
                            "expected_value": [
                                "basal cell carcinoma",
                                "squamous cell carcinoma",
                                "carcinoma in situ"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Current mild to moderate severity depressive symptoms (PHQ-8 score 5 to 19)",
            "criterions": [
                {
                    "exact_snippets": "Current mild to moderate severity depressive symptoms (PHQ-8 score 5 to 19)",
                    "criterion": "depressive symptoms",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": [
                                "mild",
                                "moderate"
                            ]
                        },
                        {
                            "requirement_type": "PHQ-8 score",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 5,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 19,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* iPhone user",
            "criterions": [
                {
                    "exact_snippets": "iPhone user",
                    "criterion": "iPhone user",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 21 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 21 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 21,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Has not completed primary cancer treatment including initial chemotherapy, surgical resection, or radiation therapy",
            "criterions": [
                {
                    "exact_snippets": "Has not completed primary cancer treatment including initial chemotherapy",
                    "criterion": "primary cancer treatment",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "surgical resection",
                    "criterion": "surgical resection",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "radiation therapy",
                    "criterion": "radiation therapy",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Non-English speaking",
            "criterions": [
                {
                    "exact_snippets": "Non-English speaking",
                    "criterion": "language proficiency",
                    "requirements": [
                        {
                            "requirement_type": "proficiency",
                            "expected_value": "non-English"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Severe depression (PHQ-8 score >=20) or active suicidal ideations",
            "criterions": [
                {
                    "exact_snippets": "Severe depression (PHQ-8 score >=20)",
                    "criterion": "severe depression",
                    "requirements": [
                        {
                            "requirement_type": "PHQ-8 score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "N/A"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "active suicidal ideations",
                    "criterion": "suicidal ideations",
                    "requirements": [
                        {
                            "requirement_type": "activity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Other severe mental illness that would preclude participation in a study that requires extensive self-monitoring, including depression with psychotic features, other psychotic disorder, bipolar disorder, severe personality disorder",
            "criterions": [
                {
                    "exact_snippets": "Other severe mental illness ... including depression with psychotic features",
                    "criterion": "depression with psychotic features",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Other severe mental illness ... other psychotic disorder",
                    "criterion": "other psychotic disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Other severe mental illness ... bipolar disorder",
                    "criterion": "bipolar disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Other severe mental illness ... severe personality disorder",
                    "criterion": "severe personality disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* <6 months life expectancy due to cancer or other severe medical illness",
            "criterions": [
                {
                    "exact_snippets": "<6 months life expectancy",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "due to cancer",
                    "criterion": "cancer",
                    "requirements": [
                        {
                            "requirement_type": "cause of reduced life expectancy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other severe medical illness",
                    "criterion": "severe medical illness",
                    "requirements": [
                        {
                            "requirement_type": "cause of reduced life expectancy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Other severe medical illness that would preclude ability to do daily self-tracking",
            "criterions": [
                {
                    "exact_snippets": "Other severe medical illness",
                    "criterion": "severe medical illness",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    ]
                },
                {
                    "exact_snippets": "preclude ability to do daily self-tracking",
                    "criterion": "ability to do daily self-tracking",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Unavailable for follow-up over the course of the 3 month trial",
            "criterions": [
                {
                    "exact_snippets": "Unavailable for follow-up over the course of the 3 month trial",
                    "criterion": "availability for follow-up",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}