{
    "info": {
        "nct_id": "NCT03160482",
        "official_title": "Evaluation of PACE4 Isoforms as Biomarkers in Thyroid Cancer",
        "inclusion_criteria": "* Men of women, aged 18-100 y.-o.\n* History of subtotal or total thyroidectomy at the \"Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke\" (CIUSSS de l'Estrie - CHUS) between January 2010 and May 2016.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 100 Years",
        "exclusion_criteria": "* Refusal to participate to the study.\n* Unavailability of the formalin-fixed, paraffin-embedded tissues.\n* Uncertain pathological diagnosis.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Men of women, aged 18-100 y.-o.",
            "criterions": [
                {
                    "exact_snippets": "aged 18-100 y.-o.",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Men of women",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "inclusion",
                            "expected_value": [
                                "men",
                                "women"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of subtotal or total thyroidectomy at the \"Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke\" (CIUSSS de l'Estrie - CHUS) between January 2010 and May 2016.",
            "criterions": [
                {
                    "exact_snippets": "History of subtotal or total thyroidectomy",
                    "criterion": "thyroidectomy",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "subtotal",
                                "total"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "at the \"Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke\" (CIUSSS de l'Estrie - CHUS)",
                    "criterion": "location of thyroidectomy",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)"
                        }
                    ]
                },
                {
                    "exact_snippets": "between January 2010 and May 2016",
                    "criterion": "date of thyroidectomy",
                    "requirements": [
                        {
                            "requirement_type": "date range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2010,
                                        "unit": "year"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2016,
                                        "unit": "year"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 100 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 100 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 100,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Refusal to participate to the study.",
            "criterions": [
                {
                    "exact_snippets": "Refusal to participate to the study.",
                    "criterion": "willingness to participate",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Unavailability of the formalin-fixed, paraffin-embedded tissues.",
            "criterions": [
                {
                    "exact_snippets": "Unavailability of the formalin-fixed, paraffin-embedded tissues.",
                    "criterion": "formalin-fixed, paraffin-embedded tissues",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Uncertain pathological diagnosis.",
            "criterions": [
                {
                    "exact_snippets": "Uncertain pathological diagnosis",
                    "criterion": "pathological diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "certainty",
                            "expected_value": "uncertain"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}