{
    "info": {
        "nct_id": "NCT03029182",
        "official_title": "Simulated-Altitude as an Adjunct to Optimize Aerobic Exercise in Obese Breast Cancer Survivors With Limited Ambulatory Function: Pilot Randomized Trial",
        "inclusion_criteria": "1. Physician's medical clearance for participation\n2. English-speaking women\n3. 18-70 years of age with a history of Stage 0-III breast cancer\n4. Preferred walking speed of less than 2.9 mph as measured by a timed 10 meter walk test (to be performed on-site after consent during preliminary screening) \"OR\" the inability to complete a 6-minute walk without stopping (to be performed on-site after consent during preliminary screening)\n5. Body mass index between 30-45 kg/m2\n6. ≥1 year post-treatment and not currently receiving or planning to receive chemo/radiation therapies\n7. Not participating in a structured exercise routine\n8. In the previous 6 months, not engaging in (on average) ≥60 minutes of moderate or ≥30 minutes of vigorous physical activity per week.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "1. Males\n2. Dementia\n3. Medical, psychological, and/or social characteristics that may interfere with the ability to fully participate in the proposed study activities/assessments (e.g., psychosis, schizophrenia)\n4. Contraindication to participate in regular exercise training\n5. Unwilling to complete prescribed exercise\n6. Inability to walk\n7. Pregnant\n8. Resting oxygen saturation via pulse oximetry below 90%\n9. Using home oxygen therapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Physician's medical clearance for participation",
            "criterions": [
                {
                    "exact_snippets": "Physician's medical clearance",
                    "criterion": "medical clearance",
                    "requirements": [
                        {
                            "requirement_type": "authorization",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. English-speaking women",
            "criterions": [
                {
                    "exact_snippets": "English-speaking",
                    "criterion": "language",
                    "requirements": [
                        {
                            "requirement_type": "proficiency",
                            "expected_value": "English"
                        }
                    ]
                },
                {
                    "exact_snippets": "women",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "identity",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. 18-70 years of age with a history of Stage 0-III breast cancer",
            "criterions": [
                {
                    "exact_snippets": "18-70 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 70,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "history of Stage 0-III breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Preferred walking speed of less than 2.9 mph as measured by a timed 10 meter walk test (to be performed on-site after consent during preliminary screening) \"OR\" the inability to complete a 6-minute walk without stopping (to be performed on-site after consent during preliminary screening)",
            "criterions": [
                {
                    "exact_snippets": "Preferred walking speed of less than 2.9 mph",
                    "criterion": "preferred walking speed",
                    "requirements": [
                        {
                            "requirement_type": "speed",
                            "expected_value": {
                                "operator": "<",
                                "value": 2.9,
                                "unit": "mph"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "inability to complete a 6-minute walk without stopping",
                    "criterion": "ability to complete a 6-minute walk without stopping",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Body mass index between 30-45 kg/m2",
            "criterions": [
                {
                    "exact_snippets": "Body mass index between 30-45 kg/m2",
                    "criterion": "body mass index",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 30,
                                        "unit": "kg/m2"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 45,
                                        "unit": "kg/m2"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. ≥1 year post-treatment and not currently receiving or planning to receive chemo/radiation therapies",
            "criterions": [
                {
                    "exact_snippets": "≥1 year post-treatment",
                    "criterion": "post-treatment duration",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "not currently receiving ... chemo/radiation therapies",
                    "criterion": "current chemo/radiation therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "not ... planning to receive chemo/radiation therapies",
                    "criterion": "planned chemo/radiation therapy",
                    "requirements": [
                        {
                            "requirement_type": "intention",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Not participating in a structured exercise routine",
            "criterions": [
                {
                    "exact_snippets": "Not participating in a structured exercise routine",
                    "criterion": "structured exercise routine",
                    "requirements": [
                        {
                            "requirement_type": "participation",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. In the previous 6 months, not engaging in (on average) ≥60 minutes of moderate or ≥30 minutes of vigorous physical activity per week.",
            "criterions": [
                {
                    "exact_snippets": "In the previous 6 months, not engaging in (on average) ≥60 minutes of moderate ... physical activity per week.",
                    "criterion": "moderate physical activity",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 60,
                                "unit": "minutes per week"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "In the previous 6 months, not engaging in (on average) ... ≥30 minutes of vigorous physical activity per week.",
                    "criterion": "vigorous physical activity",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "minutes per week"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Males",
            "criterions": [
                {
                    "exact_snippets": "Males",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "male"
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. Dementia",
            "criterions": [
                {
                    "exact_snippets": "Dementia",
                    "criterion": "dementia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. Medical, psychological, and/or social characteristics that may interfere with the ability to fully participate in the proposed study activities/assessments (e.g., psychosis, schizophrenia)",
            "criterions": [
                {
                    "exact_snippets": "Medical, psychological, and/or social characteristics that may interfere with the ability to fully participate",
                    "criterion": "interference with study participation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "psychosis",
                    "criterion": "psychosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "schizophrenia",
                    "criterion": "schizophrenia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. Contraindication to participate in regular exercise training",
            "criterions": [
                {
                    "exact_snippets": "Contraindication to participate in regular exercise training",
                    "criterion": "contraindication to exercise",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. Unwilling to complete prescribed exercise",
            "criterions": [
                {
                    "exact_snippets": "Unwilling to complete prescribed exercise",
                    "criterion": "willingness to complete prescribed exercise",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "6. Inability to walk",
            "criterions": [
                {
                    "exact_snippets": "Inability to walk",
                    "criterion": "ability to walk",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "7. Pregnant",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "8. Resting oxygen saturation via pulse oximetry below 90%",
            "criterions": [
                {
                    "exact_snippets": "Resting oxygen saturation via pulse oximetry below 90%",
                    "criterion": "resting oxygen saturation",
                    "requirements": [
                        {
                            "requirement_type": "measurement",
                            "expected_value": {
                                "operator": "<",
                                "value": 90,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "9. Using home oxygen therapy",
            "criterions": [
                {
                    "exact_snippets": "Using home oxygen therapy",
                    "criterion": "home oxygen therapy",
                    "requirements": [
                        {
                            "requirement_type": "usage",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}