{
    "info": {
        "nct_id": "NCT03025360",
        "official_title": "Expanded Access to Provide Larotrectinib (LOXO-101) for the Treatment of Cancers With a NTRK Gene Fusion",
        "inclusion_criteria": "* Diagnosis of cancer with a NTRK1, NTRK2, or NTRK3 gene fusion\n* Subjects are unable to participate in an ongoing larotrectinib clinical trial\n* Medically suitable for treatment with larotrectinib\nHealthy volunteers allowed",
        "exclusion_criteria": "* Currently enrolled in an ongoing clinical study of larotrectinib or another TRK inhibitor",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Diagnosis of cancer with a NTRK1, NTRK2, or NTRK3 gene fusion",
            "criterions": [
                {
                    "exact_snippets": "Diagnosis of cancer",
                    "criterion": "cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "NTRK1, NTRK2, or NTRK3 gene fusion",
                    "criterion": "NTRK gene fusion",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "NTRK1",
                                "NTRK2",
                                "NTRK3"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Subjects are unable to participate in an ongoing larotrectinib clinical trial",
            "criterions": [
                {
                    "exact_snippets": "unable to participate in an ongoing larotrectinib clinical trial",
                    "criterion": "participation in larotrectinib clinical trial",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Medically suitable for treatment with larotrectinib",
            "criterions": [
                {
                    "exact_snippets": "Medically suitable for treatment with larotrectinib",
                    "criterion": "suitability for treatment with larotrectinib",
                    "requirements": [
                        {
                            "requirement_type": "suitability",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Currently enrolled in an ongoing clinical study of larotrectinib or another TRK inhibitor",
            "criterions": [
                {
                    "exact_snippets": "Currently enrolled in an ongoing clinical study of larotrectinib",
                    "criterion": "enrollment in clinical study",
                    "requirements": [
                        {
                            "requirement_type": "drug",
                            "expected_value": "larotrectinib"
                        }
                    ]
                },
                {
                    "exact_snippets": "Currently enrolled in an ongoing clinical study of ... another TRK inhibitor",
                    "criterion": "enrollment in clinical study",
                    "requirements": [
                        {
                            "requirement_type": "drug",
                            "expected_value": "TRK inhibitor"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}