{
    "info": {
        "nct_id": "NCT02934880",
        "official_title": "Study of Impact of Adapted Physical Activity on Cognitive Functions and Quality of Life in Patients Treated for Locally Advanced Breast Cancer",
        "inclusion_criteria": "* Women\n* More than 18 years old\n* Locally advanced breast cancer\n* Patient who undergone surgery\n* Cognitive complaint (FACT-COG inferior or equal to 8/16)\n* No metastasis at the inclusion\n* Patient who received adjuvant therapy by chemotherapy\n* Patient with a social protection\n* Barbizet scale Superior or equal to 3\n* No neurological history\n* No medical contraindication to APA\n* Inform consent signed\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Metastatic breast cancer\n* History of other cancer (in 5 years before inclusion)\n* Current chemotherapy or radiotherapy\n* Chemotherapy or radiotherapy ended for more than 6 months\n* Current APA program\n* Blood transfusion for less than 6 mois\n* Minimal mental score inferior to normal\n* Patient no able to respond to the cognitive test\n* Patient no able to realize APA program\n* Drug use\n* Alcohol abuse\n* Patient Under guardianship or curatorship or deprived of liberty",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Women",
            "criterions": [
                {
                    "exact_snippets": "Women",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 18 years old",
            "criterions": [
                {
                    "exact_snippets": "More than 18 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "age",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Locally advanced breast cancer",
            "criterions": [
                {
                    "exact_snippets": "Locally advanced breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "locally advanced"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient who undergone surgery",
            "criterions": [
                {
                    "exact_snippets": "undergone surgery",
                    "criterion": "surgery",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Cognitive complaint (FACT-COG inferior or equal to 8/16)",
            "criterions": [
                {
                    "exact_snippets": "Cognitive complaint (FACT-COG inferior or equal to 8/16)",
                    "criterion": "cognitive complaint",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 8,
                                "unit": "16"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No metastasis at the inclusion",
            "criterions": [
                {
                    "exact_snippets": "No metastasis",
                    "criterion": "metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient who received adjuvant therapy by chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "Patient who received adjuvant therapy by chemotherapy",
                    "criterion": "adjuvant therapy",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": "chemotherapy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient with a social protection",
            "criterions": [
                {
                    "exact_snippets": "Patient with a social protection",
                    "criterion": "social protection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Barbizet scale Superior or equal to 3",
            "criterions": [
                {
                    "exact_snippets": "Barbizet scale Superior or equal to 3",
                    "criterion": "Barbizet scale",
                    "requirements": [
                        {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No neurological history",
            "criterions": [
                {
                    "exact_snippets": "No neurological history",
                    "criterion": "neurological history",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No medical contraindication to APA",
            "criterions": [
                {
                    "exact_snippets": "No medical contraindication to APA",
                    "criterion": "medical contraindication to APA",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inform consent signed",
            "criterions": [
                {
                    "exact_snippets": "Inform consent signed",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Metastatic breast cancer",
            "criterions": [
                {
                    "exact_snippets": "Metastatic breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "metastatic"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of other cancer (in 5 years before inclusion)",
            "criterions": [
                {
                    "exact_snippets": "History of other cancer (in 5 years before inclusion)",
                    "criterion": "history of other cancer",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Current chemotherapy or radiotherapy",
            "criterions": [
                {
                    "exact_snippets": "Current chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "current status",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Current ... radiotherapy",
                    "criterion": "radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "current status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Chemotherapy or radiotherapy ended for more than 6 months",
            "criterions": [
                {
                    "exact_snippets": "Chemotherapy ... ended for more than 6 months",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "end time",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "radiotherapy ended for more than 6 months",
                    "criterion": "radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "end time",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Current APA program",
            "criterions": [
                {
                    "exact_snippets": "Current APA program",
                    "criterion": "APA program",
                    "requirements": [
                        {
                            "requirement_type": "current participation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Blood transfusion for less than 6 mois",
            "criterions": [
                {
                    "exact_snippets": "Blood transfusion for less than 6 mois",
                    "criterion": "blood transfusion",
                    "requirements": [
                        {
                            "requirement_type": "time since last transfusion",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Minimal mental score inferior to normal",
            "criterions": [
                {
                    "exact_snippets": "Minimal mental score inferior to normal",
                    "criterion": "mental score",
                    "requirements": [
                        {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<",
                                "value": 0,
                                "unit": "normal"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient no able to respond to the cognitive test",
            "criterions": [
                {
                    "exact_snippets": "Patient no able to respond to the cognitive test",
                    "criterion": "cognitive test response ability",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient no able to realize APA program",
            "criterions": [
                {
                    "exact_snippets": "Patient no able to realize APA program",
                    "criterion": "ability to realize APA program",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Drug use",
            "criterions": [
                {
                    "exact_snippets": "Drug use",
                    "criterion": "drug use",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Alcohol abuse",
            "criterions": [
                {
                    "exact_snippets": "Alcohol abuse",
                    "criterion": "alcohol abuse",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient Under guardianship or curatorship or deprived of liberty",
            "criterions": [
                {
                    "exact_snippets": "Patient Under guardianship",
                    "criterion": "guardianship status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "curatorship",
                    "criterion": "curatorship status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "deprived of liberty",
                    "criterion": "liberty status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}