{
    "info": {
        "nct_id": "NCT02930876",
        "official_title": "Feasibility of Home vs. Hospital Based Resistance Training for Advanced Cancer Patients: a Phase II Trial",
        "inclusion_criteria": "- histological diagnosis of cancer, incurable (stage IIIB/IV according to AJCC 2010).\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* chemotherapy within 90 days prior to study enrollment\n* not having a baseline (pre-treatment) Computed Tomography of the Thorax Abdomen and Pelvis (CTTAP) and whole body dual x-ray absorptometry (DXA) (this is important because having an assessment of baseline muscle mass will allow us to control for baseline sarcopenia and calculate changes from baseline to post-intervention)\n* bone metastasis in risk of fracture\n* inability to comply with the intervention for any known reasons (including physical or mental impairment that limits the capacity to undertake the exercise program)\n* considered to be at cardiovascular risk (defined by a pre-exercise cardiologic evaluation with electrocardiogram (ECG) and echocardiogram when indicated (echocardiogram if >50 years old, NYHA class I, angor, cardiovascular risk factors and abnormal ECG)).",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "- histological diagnosis of cancer, incurable (stage IIIB/IV according to AJCC 2010).",
            "criterions": [
                {
                    "exact_snippets": "histological diagnosis of cancer",
                    "criterion": "cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "histological"
                        }
                    ]
                },
                {
                    "exact_snippets": "incurable (stage IIIB/IV according to AJCC 2010)",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IIIB",
                                "IV"
                            ]
                        },
                        {
                            "requirement_type": "curability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* chemotherapy within 90 days prior to study enrollment",
            "criterions": [
                {
                    "exact_snippets": "chemotherapy within 90 days prior to study enrollment",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "days"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* not having a baseline (pre-treatment) Computed Tomography of the Thorax Abdomen and Pelvis (CTTAP) and whole body dual x-ray absorptometry (DXA) (this is important because having an assessment of baseline muscle mass will allow us to control for baseline sarcopenia and calculate changes from baseline to post-intervention)",
            "criterions": [
                {
                    "exact_snippets": "not having a baseline (pre-treatment) Computed Tomography of the Thorax Abdomen and Pelvis (CTTAP)",
                    "criterion": "baseline CTTAP",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "not having a baseline (pre-treatment) ... whole body dual x-ray absorptometry (DXA)",
                    "criterion": "baseline DXA",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* bone metastasis in risk of fracture",
            "criterions": [
                {
                    "exact_snippets": "bone metastasis",
                    "criterion": "bone metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "risk of fracture",
                    "criterion": "risk of fracture",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* inability to comply with the intervention for any known reasons (including physical or mental impairment that limits the capacity to undertake the exercise program)",
            "criterions": [
                {
                    "exact_snippets": "inability to comply with the intervention",
                    "criterion": "compliance with intervention",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "physical or mental impairment that limits the capacity to undertake the exercise program",
                    "criterion": "physical or mental impairment",
                    "requirements": [
                        {
                            "requirement_type": "impact on exercise program",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* considered to be at cardiovascular risk (defined by a pre-exercise cardiologic evaluation with electrocardiogram (ECG) and echocardiogram when indicated (echocardiogram if >50 years old, NYHA class I, angor, cardiovascular risk factors and abnormal ECG)).",
            "criterions": [
                {
                    "exact_snippets": "pre-exercise cardiologic evaluation with electrocardiogram (ECG)",
                    "criterion": "pre-exercise cardiologic evaluation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "echocardiogram if >50 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "age",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "NYHA class I",
                    "criterion": "NYHA class",
                    "requirements": [
                        {
                            "requirement_type": "classification",
                            "expected_value": "I"
                        }
                    ]
                },
                {
                    "exact_snippets": "angor",
                    "criterion": "angor",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "cardiovascular risk factors",
                    "criterion": "cardiovascular risk factors",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "abnormal ECG",
                    "criterion": "ECG",
                    "requirements": [
                        {
                            "requirement_type": "abnormality",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}