{
    "info": {
        "nct_id": "NCT02890082",
        "official_title": "Pilot Study of Preservation of Fertility by Ovarian Stimulation Associated With Tamoxifen, and Freezing Oocyte or Embryo Prior Chemotherapy for Breast Cancer",
        "inclusion_criteria": "* Aged between 18 and 40\n* infiltrating breast carcinoma histologically proven\n* Indication of adjuvant or neoadjuvant chemotherapy\n* T0-T1-T2-T3\n* N0-N1-N2a\n* M0 after staging\n* AMH ≥1 ng / mL and / or account antral follicles ≥ 5\n* HIV serology negative.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 40 Years",
        "exclusion_criteria": "* breast cancer history\n* History of another cancer in the last 5 years, with the exception of basal cell skin cancer and squamous cell\n* patient in pregnancy\n* pulmonary embolism under 6 months\n* deep vein thrombosis of less than 6 months.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Aged between 18 and 40",
            "criterions": [
                {
                    "exact_snippets": "Aged between 18 and 40",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 40,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* infiltrating breast carcinoma histologically proven",
            "criterions": [
                {
                    "exact_snippets": "infiltrating breast carcinoma",
                    "criterion": "breast carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "infiltrating"
                        }
                    ]
                },
                {
                    "exact_snippets": "histologically proven",
                    "criterion": "histological proof",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Indication of adjuvant or neoadjuvant chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "Indication of adjuvant or neoadjuvant chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "indication",
                            "expected_value": [
                                "adjuvant",
                                "neoadjuvant"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* T0-T1-T2-T3",
            "criterions": [
                {
                    "exact_snippets": "T0-T1-T2-T3",
                    "criterion": "tumor stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "T0",
                                "T1",
                                "T2",
                                "T3"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* N0-N1-N2a",
            "criterions": [
                {
                    "exact_snippets": "N0-N1-N2a",
                    "criterion": "lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "N0",
                                "N1",
                                "N2a"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* M0 after staging",
            "criterions": [
                {
                    "exact_snippets": "M0 after staging",
                    "criterion": "metastasis",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "M0"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* AMH ≥1 ng / mL and / or account antral follicles ≥ 5",
            "criterions": [
                {
                    "exact_snippets": "AMH ≥1 ng / mL",
                    "criterion": "AMH level",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "ng/mL"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "account antral follicles ≥ 5",
                    "criterion": "antral follicle count",
                    "requirements": [
                        {
                            "requirement_type": "count",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* HIV serology negative.",
            "criterions": [
                {
                    "exact_snippets": "HIV serology negative",
                    "criterion": "HIV serology",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 40 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 40 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 40,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* breast cancer history",
            "criterions": [
                {
                    "exact_snippets": "breast cancer history",
                    "criterion": "breast cancer history",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of another cancer in the last 5 years, with the exception of basal cell skin cancer and squamous cell",
            "criterions": [
                {
                    "exact_snippets": "History of another cancer in the last 5 years",
                    "criterion": "history of another cancer",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "with the exception of basal cell skin cancer and squamous cell",
                    "criterion": "type of cancer",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": [
                                "basal cell skin cancer",
                                "squamous cell"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* patient in pregnancy",
            "criterions": [
                {
                    "exact_snippets": "patient in pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* pulmonary embolism under 6 months",
            "criterions": [
                {
                    "exact_snippets": "pulmonary embolism under 6 months",
                    "criterion": "pulmonary embolism",
                    "requirements": [
                        {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* deep vein thrombosis of less than 6 months.",
            "criterions": [
                {
                    "exact_snippets": "deep vein thrombosis of less than 6 months",
                    "criterion": "deep vein thrombosis",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}