{
    "info": {
        "nct_id": "NCT02765620",
        "official_title": "PERCIST Criteria for Response Evaluation of Non-surgical Therapy in Patients With Solid Tumors:Prospective Multicenter Study",
        "inclusion_criteria": "* Age 30-80 years old ( might differ based on certain cancer type)\n* Newly diagnosis of solid tumor proved by imaging\n* Pathology proved to be primary solid tumor\n* First PET/CT scan was performed before any kinds of anti-tumor treatment including surgery\n* No other anti-tumor treatments except for that required during the trial\n* Written and informed consent with signature before the study\n* Complete medical history and clinical record (including physical examination, electrocardiogram, hematology, biochemistry, tumor pathology etc)\n* Follow-up of PSF and OS over a year\nHealthy volunteers allowed\nMust have minimum age of 30 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Pregnancy, lactation, and impaired renal or liver function\n* Receive additional anti-tumor treatments (including surgery) other than that required during the trial\n* Poorly controlled diabetes\n* Poor compliance\n* Failed to perform scans\n* Contrary to the standard operating procedures\n* Without a definite pathologic diagnosis or follow-up results\n* Not suitable for clinical trials (for example with mental illness)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age 30-80 years old ( might differ based on certain cancer type)",
            "criterions": [
                {
                    "exact_snippets": "Age 30-80 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 30,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 80,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Newly diagnosis of solid tumor proved by imaging",
            "criterions": [
                {
                    "exact_snippets": "Newly diagnosis of solid tumor",
                    "criterion": "solid tumor",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": "newly"
                        }
                    ]
                },
                {
                    "exact_snippets": "proved by imaging",
                    "criterion": "imaging proof",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pathology proved to be primary solid tumor",
            "criterions": [
                {
                    "exact_snippets": "Pathology proved to be primary solid tumor",
                    "criterion": "primary solid tumor",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* First PET/CT scan was performed before any kinds of anti-tumor treatment including surgery",
            "criterions": [
                {
                    "exact_snippets": "First PET/CT scan was performed before any kinds of anti-tumor treatment including surgery",
                    "criterion": "PET/CT scan",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "before any kinds of anti-tumor treatment including surgery"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No other anti-tumor treatments except for that required during the trial",
            "criterions": [
                {
                    "exact_snippets": "No other anti-tumor treatments",
                    "criterion": "anti-tumor treatments",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Written and informed consent with signature before the study",
            "criterions": [
                {
                    "exact_snippets": "Written and informed consent with signature",
                    "criterion": "consent",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "written and informed"
                        },
                        {
                            "requirement_type": "signature",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Complete medical history and clinical record (including physical examination, electrocardiogram, hematology, biochemistry, tumor pathology etc)",
            "criterions": [
                {
                    "exact_snippets": "Complete medical history",
                    "criterion": "medical history",
                    "requirements": [
                        {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "clinical record",
                    "criterion": "clinical record",
                    "requirements": [
                        {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "physical examination",
                    "criterion": "physical examination",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "electrocardiogram",
                    "criterion": "electrocardiogram",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "hematology",
                    "criterion": "hematology",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "biochemistry",
                    "criterion": "biochemistry",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "tumor pathology",
                    "criterion": "tumor pathology",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Follow-up of PSF and OS over a year",
            "criterions": [
                {
                    "exact_snippets": "Follow-up of PSF",
                    "criterion": "PSF follow-up",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "=",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Follow-up of ... OS",
                    "criterion": "OS follow-up",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "=",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 30 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 30 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 80 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Pregnancy, lactation, and impaired renal or liver function",
            "criterions": [
                {
                    "exact_snippets": "Pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactation",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "impaired renal ... function",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "impairment",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "impaired ... liver function",
                    "criterion": "liver function",
                    "requirements": [
                        {
                            "requirement_type": "impairment",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Receive additional anti-tumor treatments (including surgery) other than that required during the trial",
            "criterions": [
                {
                    "exact_snippets": "Receive additional anti-tumor treatments (including surgery)",
                    "criterion": "additional anti-tumor treatments",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Poorly controlled diabetes",
            "criterions": [
                {
                    "exact_snippets": "Poorly controlled diabetes",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": "poorly controlled"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Poor compliance",
            "criterions": [
                {
                    "exact_snippets": "Poor compliance",
                    "criterion": "compliance",
                    "requirements": [
                        {
                            "requirement_type": "quality",
                            "expected_value": "poor"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Failed to perform scans",
            "criterions": [
                {
                    "exact_snippets": "Failed to perform scans",
                    "criterion": "scans",
                    "requirements": [
                        {
                            "requirement_type": "performance",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Without a definite pathologic diagnosis or follow-up results",
            "criterions": [
                {
                    "exact_snippets": "Without a definite pathologic diagnosis",
                    "criterion": "pathologic diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Without ... follow-up results",
                    "criterion": "follow-up results",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Not suitable for clinical trials (for example with mental illness)",
            "criterions": [
                {
                    "exact_snippets": "Not suitable for clinical trials (for example with mental illness)",
                    "criterion": "suitability for clinical trials",
                    "requirements": [
                        {
                            "requirement_type": "suitability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "mental illness",
                    "criterion": "mental illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* Contrary to the standard operating procedures",
            "criterions": []
        }
    ],
    "failed_miscellaneous": []
}