{
    "info": {
        "nct_id": "NCT02739620",
        "official_title": "Alternative Exercise Program to Improve Skeletal Muscle Function and Fatigue in Cancer Survivors",
        "inclusion_criteria": "1. stage I, II or III breast cancer\n2. receiving neoadjuvant or adjuvant chemotherapy with or without radiation\n3. a body mass index <35 kg/m2.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 40 Years\nMust have maximum age of 70 Years",
        "exclusion_criteria": "1. metastatic disease, a prior history of cancer, excluding non-melanoma skin cancer, or prior receipt of chemotherapy\n2. autoimmune, vascular or neuromuscular disease that could alter skeletal muscle\n3. prior knee or hip replacement\n4. contraindications for use of neuromuscular electrical stimulation, including an implanted cardiac defibrillator or pacemaker, lower extremity blood clot or coagulopathy\n5. pregnancy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. stage I, II or III breast cancer",
            "criterions": [
                {
                    "exact_snippets": "stage I, II or III breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "I",
                                "II",
                                "III"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. receiving neoadjuvant or adjuvant chemotherapy with or without radiation",
            "criterions": [
                {
                    "exact_snippets": "receiving neoadjuvant or adjuvant chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "treatment phase",
                            "expected_value": [
                                "neoadjuvant",
                                "adjuvant"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "with or without radiation",
                    "criterion": "radiation therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. a body mass index <35 kg/m2.",
            "criterions": [
                {
                    "exact_snippets": "body mass index <35 kg/m2",
                    "criterion": "body mass index",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 35,
                                "unit": "kg/m2"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 40 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 40 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 40,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 70 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 70 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 70,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. metastatic disease, a prior history of cancer, excluding non-melanoma skin cancer, or prior receipt of chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "metastatic disease",
                    "criterion": "metastatic disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "a prior history of cancer",
                    "criterion": "prior history of cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "excluding non-melanoma skin cancer",
                    "criterion": "non-melanoma skin cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "prior receipt of chemotherapy",
                    "criterion": "prior receipt of chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "2. autoimmune, vascular or neuromuscular disease that could alter skeletal muscle",
            "criterions": [
                {
                    "exact_snippets": "autoimmune ... disease that could alter skeletal muscle",
                    "criterion": "autoimmune disease",
                    "requirements": [
                        {
                            "requirement_type": "potential to alter skeletal muscle",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "vascular ... disease that could alter skeletal muscle",
                    "criterion": "vascular disease",
                    "requirements": [
                        {
                            "requirement_type": "potential to alter skeletal muscle",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "neuromuscular disease that could alter skeletal muscle",
                    "criterion": "neuromuscular disease",
                    "requirements": [
                        {
                            "requirement_type": "potential to alter skeletal muscle",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "3. prior knee or hip replacement",
            "criterions": [
                {
                    "exact_snippets": "prior knee or hip replacement",
                    "criterion": "knee replacement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "prior knee or hip replacement",
                    "criterion": "hip replacement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "4. contraindications for use of neuromuscular electrical stimulation, including an implanted cardiac defibrillator or pacemaker, lower extremity blood clot or coagulopathy",
            "criterions": [
                {
                    "exact_snippets": "contraindications for use of neuromuscular electrical stimulation, including an implanted cardiac defibrillator",
                    "criterion": "implanted cardiac defibrillator",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "contraindications for use of neuromuscular electrical stimulation, including ... pacemaker",
                    "criterion": "pacemaker",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "contraindications for use of neuromuscular electrical stimulation, including ... lower extremity blood clot",
                    "criterion": "lower extremity blood clot",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "contraindications for use of neuromuscular electrical stimulation, including ... coagulopathy",
                    "criterion": "coagulopathy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "5. pregnancy",
            "criterions": [
                {
                    "exact_snippets": "pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}