{
    "info": {
        "nct_id": "NCT02713087",
        "official_title": "Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors",
        "inclusion_criteria": "* Patients scheduled for supine-positioned elective craniotomy for supratentorial malignant and non-malignant brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)\n* ASA (American Society of Anesthesiologist) status 1-3 (27)\n* Written informed consent from participating patients\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Age younger than 18 yrs. or older than 75 yrs.\n* Pregnancy or nursing (negative pregnancy blood test)\n* History of allergic reactions to phenylephrine or ephedrine\n* eGFR < 60ml/min/1.73m2",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patients scheduled for supine-positioned elective craniotomy for supratentorial malignant and non-malignant brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)",
            "criterions": [
                {
                    "exact_snippets": "scheduled for supine-positioned elective craniotomy",
                    "criterion": "surgical procedure",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "supine-positioned elective craniotomy"
                        }
                    ]
                },
                {
                    "exact_snippets": "supratentorial malignant and non-malignant brain tumors",
                    "criterion": "brain tumor location",
                    "requirements": [
                        {
                            "requirement_type": "location",
                            "expected_value": "supratentorial"
                        }
                    ]
                },
                {
                    "exact_snippets": "malignant and non-malignant brain tumors",
                    "criterion": "brain tumor type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "malignant",
                                "non-malignant"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)",
                    "criterion": "brain tumor size",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ASA (American Society of Anesthesiologist) status 1-3 (27)",
            "criterions": [
                {
                    "exact_snippets": "ASA (American Society of Anesthesiologist) status 1-3",
                    "criterion": "ASA status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Written informed consent from participating patients",
            "criterions": [
                {
                    "exact_snippets": "Written informed consent from participating patients",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Age younger than 18 yrs. or older than 75 yrs.",
            "criterions": [
                {
                    "exact_snippets": "Age younger than 18 yrs.",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "yrs."
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Age ... older than 75 yrs.",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">",
                                "value": 75,
                                "unit": "yrs."
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnancy or nursing (negative pregnancy blood test)",
            "criterions": [
                {
                    "exact_snippets": "Pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "nursing",
                    "criterion": "nursing",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "negative pregnancy blood test",
                    "criterion": "pregnancy blood test",
                    "requirements": [
                        {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of allergic reactions to phenylephrine or ephedrine",
            "criterions": [
                {
                    "exact_snippets": "History of allergic reactions to phenylephrine",
                    "criterion": "allergic reactions to phenylephrine",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "History of allergic reactions to ... ephedrine",
                    "criterion": "allergic reactions to ephedrine",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* eGFR < 60ml/min/1.73m2",
            "criterions": [
                {
                    "exact_snippets": "eGFR < 60ml/min/1.73m2",
                    "criterion": "eGFR",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<",
                                "value": 60,
                                "unit": "ml/min/1.73m2"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}