{
    "info": {
        "nct_id": "NCT02476682",
        "official_title": "Evaluation of Stool and Blood Based Tests for Colorectal Advanced Mucosal Neoplasia",
        "inclusion_criteria": "* Individuals capable and willing of proving satisfactory informed consent\n* Individuals with colonic lesions larger than 20mm\n* Individuals diagnosed with laterally spreading or sessile polyp morphology\n* Individuals schedules for screening colonoscopy and with no prior history of CRC\n* Ability and willingness to collect stool sample at home\n* Ability and willingness to undergo venepuncture procedure\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Individuals not able or unwilling to provide informed consent\n* Individuals less than 18 year of age\n* Individuals who undergo an incomplete colonoscopy or resection, which raises doubt as to the status of the colon (post-hoc exclusion)\n* Individuals with a prior history of CRC\n* Individuals with a history of Irritable Bowel Disease (IBD), hereditary nonpolyposis colorectal cancer (HNPCC) or Familial adenomatous polyposis (FAP)\n* Individuals with bleeding diathesis\n* Pregnancy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Individuals capable and willing of proving satisfactory informed consent",
            "criterions": [
                {
                    "exact_snippets": "capable and willing of proving satisfactory informed consent",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "capability",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals with colonic lesions larger than 20mm",
            "criterions": [
                {
                    "exact_snippets": "colonic lesions larger than 20mm",
                    "criterion": "colonic lesions",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">",
                                "value": 20,
                                "unit": "mm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals diagnosed with laterally spreading or sessile polyp morphology",
            "criterions": [
                {
                    "exact_snippets": "diagnosed with laterally spreading ... polyp morphology",
                    "criterion": "laterally spreading polyp morphology",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "diagnosed with ... sessile polyp morphology",
                    "criterion": "sessile polyp morphology",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals schedules for screening colonoscopy and with no prior history of CRC",
            "criterions": [
                {
                    "exact_snippets": "Individuals schedules for screening colonoscopy",
                    "criterion": "screening colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "scheduled",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "no prior history of CRC",
                    "criterion": "prior history of CRC",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Ability and willingness to collect stool sample at home",
            "criterions": [
                {
                    "exact_snippets": "Ability and willingness to collect stool sample at home",
                    "criterion": "stool sample collection",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Ability and willingness to undergo venepuncture procedure",
            "criterions": [
                {
                    "exact_snippets": "Ability ... to undergo venepuncture procedure",
                    "criterion": "venepuncture procedure",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "willingness to undergo venepuncture procedure",
                    "criterion": "venepuncture procedure",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Individuals not able or unwilling to provide informed consent",
            "criterions": [
                {
                    "exact_snippets": "not able ... to provide informed consent",
                    "criterion": "ability to provide informed consent",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "not ... willing to provide informed consent",
                    "criterion": "willingness to provide informed consent",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals less than 18 year of age",
            "criterions": [
                {
                    "exact_snippets": "less than 18 year of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "year"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals who undergo an incomplete colonoscopy or resection, which raises doubt as to the status of the colon (post-hoc exclusion)",
            "criterions": [
                {
                    "exact_snippets": "undergo an incomplete colonoscopy",
                    "criterion": "colonoscopy",
                    "requirements": [
                        {
                            "requirement_type": "completeness",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "undergo an incomplete ... resection",
                    "criterion": "resection",
                    "requirements": [
                        {
                            "requirement_type": "completeness",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals with a prior history of CRC",
            "criterions": [
                {
                    "exact_snippets": "prior history of CRC",
                    "criterion": "CRC (Colorectal Cancer)",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals with a history of Irritable Bowel Disease (IBD), hereditary nonpolyposis colorectal cancer (HNPCC) or Familial adenomatous polyposis (FAP)",
            "criterions": [
                {
                    "exact_snippets": "history of Irritable Bowel Disease (IBD)",
                    "criterion": "Irritable Bowel Disease (IBD)",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of ... hereditary nonpolyposis colorectal cancer (HNPCC)",
                    "criterion": "hereditary nonpolyposis colorectal cancer (HNPCC)",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "history of ... Familial adenomatous polyposis (FAP)",
                    "criterion": "Familial adenomatous polyposis (FAP)",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Individuals with bleeding diathesis",
            "criterions": [
                {
                    "exact_snippets": "bleeding diathesis",
                    "criterion": "bleeding diathesis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnancy",
            "criterions": [
                {
                    "exact_snippets": "Pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}