{
    "info": {
        "nct_id": "NCT02075060",
        "official_title": "",
        "inclusion_criteria": "* Age > 18 years,\n* Primary or recurrent bladder tumor with endoscopic papillary aspect,\n* One or two bladder tumors,\n* Cytology before TURB showing no high-grade cells,\n* Patients without tutorship or subordination (ou curatorship),\n* Patients under the general social security system or qualifying through a third party,\n* Informed consent signed by the patient after clear and fair information.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Age < 18 years,\n* Allergy to mitomycin C,\n* Traumatic stenting,\n* Upper tract urothelial cancer,\n* Urethral invasion,\n* History of muscle invasive bladder cancer,\n* Extensive tumor (3 cm or more),\n* Any contraindication to TURB,\n* Simultaneous participation in another clinical research study,\n* Patients not insured by the social security or not qualifying through a third party,\n* Patients with enhanced protection, namely pregnant or lactating women, persons deprived of their liberty by a judicial or administrative decision, people staying in a health or social institution, adults under legal protection, and finally patients in emergency situations,\n* Pregnant or lactating females or women of childbearing potential not willing to use an adequate method of birth control for the duration of the study (i.e. hormonal / mechanical contraceptive : oral, injectable, transdermal, implantable, intrauterine or surgical device: tubal ligation, hysterectomy, total oophorectomy).",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age > 18 years,",
            "criterions": [
                {
                    "exact_snippets": "Age > 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Primary or recurrent bladder tumor with endoscopic papillary aspect,",
            "criterions": [
                {
                    "exact_snippets": "Primary or recurrent bladder tumor",
                    "criterion": "bladder tumor",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "primary",
                                "recurrent"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "endoscopic papillary aspect",
                    "criterion": "tumor aspect",
                    "requirements": [
                        {
                            "requirement_type": "appearance",
                            "expected_value": "endoscopic papillary"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* One or two bladder tumors,",
            "criterions": [
                {
                    "exact_snippets": "One or two bladder tumors",
                    "criterion": "bladder tumors",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Cytology before TURB showing no high-grade cells,",
            "criterions": [
                {
                    "exact_snippets": "Cytology before TURB showing no high-grade cells",
                    "criterion": "cytology before TURB",
                    "requirements": [
                        {
                            "requirement_type": "presence of high-grade cells",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients without tutorship or subordination (ou curatorship),",
            "criterions": [
                {
                    "exact_snippets": "Patients without tutorship or subordination (ou curatorship)",
                    "criterion": "tutorship or subordination",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients under the general social security system or qualifying through a third party,",
            "criterions": [
                {
                    "exact_snippets": "Patients under the general social security system",
                    "criterion": "social security system",
                    "requirements": [
                        {
                            "requirement_type": "enrollment",
                            "expected_value": "general"
                        }
                    ]
                },
                {
                    "exact_snippets": "qualifying through a third party",
                    "criterion": "third party qualification",
                    "requirements": [
                        {
                            "requirement_type": "qualification",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Informed consent signed by the patient after clear and fair information.",
            "criterions": [
                {
                    "exact_snippets": "Informed consent signed by the patient",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "after clear and fair information",
                    "criterion": "information provided",
                    "requirements": [
                        {
                            "requirement_type": "clarity and fairness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Age < 18 years,",
            "criterions": [
                {
                    "exact_snippets": "Age < 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Allergy to mitomycin C,",
            "criterions": [
                {
                    "exact_snippets": "Allergy to mitomycin C",
                    "criterion": "allergy",
                    "requirements": [
                        {
                            "requirement_type": "substance",
                            "expected_value": "mitomycin C"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Traumatic stenting,",
            "criterions": [
                {
                    "exact_snippets": "Traumatic stenting",
                    "criterion": "traumatic stenting",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Upper tract urothelial cancer,",
            "criterions": [
                {
                    "exact_snippets": "Upper tract urothelial cancer",
                    "criterion": "upper tract urothelial cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Urethral invasion,",
            "criterions": [
                {
                    "exact_snippets": "Urethral invasion",
                    "criterion": "urethral invasion",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of muscle invasive bladder cancer,",
            "criterions": [
                {
                    "exact_snippets": "History of muscle invasive bladder cancer",
                    "criterion": "muscle invasive bladder cancer",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Extensive tumor (3 cm or more),",
            "criterions": [
                {
                    "exact_snippets": "Extensive tumor (3 cm or more)",
                    "criterion": "tumor size",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Any contraindication to TURB,",
            "criterions": [
                {
                    "exact_snippets": "Any contraindication to TURB",
                    "criterion": "contraindication to TURB",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Simultaneous participation in another clinical research study,",
            "criterions": [
                {
                    "exact_snippets": "Simultaneous participation in another clinical research study",
                    "criterion": "simultaneous participation in another clinical research study",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients not insured by the social security or not qualifying through a third party,",
            "criterions": [
                {
                    "exact_snippets": "Patients not insured by the social security",
                    "criterion": "insurance status",
                    "requirements": [
                        {
                            "requirement_type": "coverage",
                            "expected_value": "not insured by the social security"
                        }
                    ]
                },
                {
                    "exact_snippets": "not qualifying through a third party",
                    "criterion": "insurance qualification",
                    "requirements": [
                        {
                            "requirement_type": "qualification",
                            "expected_value": "not qualifying through a third party"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with enhanced protection, namely pregnant or lactating women, persons deprived of their liberty by a judicial or administrative decision, people staying in a health or social institution, adults under legal protection, and finally patients in emergency situations,",
            "criterions": [
                {
                    "exact_snippets": "pregnant or lactating women",
                    "criterion": "pregnancy or lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "persons deprived of their liberty by a judicial or administrative decision",
                    "criterion": "deprivation of liberty",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "people staying in a health or social institution",
                    "criterion": "residence in health or social institution",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adults under legal protection",
                    "criterion": "legal protection status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "patients in emergency situations",
                    "criterion": "emergency situation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant or lactating females or women of childbearing potential not willing to use an adequate method of birth control for the duration of the study (i.e. hormonal / mechanical contraceptive : oral, injectable, transdermal, implantable, intrauterine or surgical device: tubal ligation, hysterectomy, total oophorectomy).",
            "criterions": [
                {
                    "exact_snippets": "Pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lactating",
                    "criterion": "lactation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "women of childbearing potential not willing to use an adequate method of birth control",
                    "criterion": "willingness to use birth control",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}