{
    "info": {
        "nct_id": "NCT01752101",
        "official_title": "Identification of a Plasma Proteomic Signature for Lung Cancer",
        "inclusion_criteria": "* age ≥ 40\n* any smoking status, e.g. current, former, or never\n* co-morbid conditions, e.g. COPD\n* Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity\n* Pathology: malignant - adenocarcinoma, squamous, or large cell\n* Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)\n* Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)\n* Clinical stage, Regional lymph nodes: N0 or N1 only\n* Clinical stage, Distant metastasis: M0 only\nHealthy volunteers allowed\nMust have minimum age of 40 Years",
        "exclusion_criteria": "* prior malignancy within 5 years of lung nodule diagnosis\n* No nodule size available\n* No pathology data available for those with\n* Current diagnosis of non-small cell lung cancer\n* Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* age ≥ 40",
            "criterions": [
                {
                    "exact_snippets": "age ≥ 40",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 40,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* any smoking status, e.g. current, former, or never",
            "criterions": [
                {
                    "exact_snippets": "any smoking status, e.g. current, former, or never",
                    "criterion": "smoking status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* co-morbid conditions, e.g. COPD",
            "criterions": [
                {
                    "exact_snippets": "co-morbid conditions",
                    "criterion": "co-morbid conditions",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "COPD",
                    "criterion": "COPD",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity",
            "criterions": [
                {
                    "exact_snippets": "Nodule size ≥ 4 mm and ≤ 30 mm",
                    "criterion": "nodule size",
                    "requirements": [
                        {
                            "requirement_type": "size",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "mm"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 30,
                                        "unit": "mm"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "up to Stage 2B eligible",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "B"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "any spiculation",
                    "criterion": "nodule spiculation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "ground glass opacity",
                    "criterion": "ground glass opacity",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pathology: malignant - adenocarcinoma, squamous, or large cell",
            "criterions": [
                {
                    "exact_snippets": "Pathology: malignant - adenocarcinoma, squamous, or large cell",
                    "criterion": "pathology",
                    "requirements": [
                        {
                            "requirement_type": "malignancy",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "adenocarcinoma",
                                "squamous",
                                "large cell"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)",
            "criterions": [
                {
                    "exact_snippets": "Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)",
                    "criterion": "clinical stage of primary tumor",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "T"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage, Regional lymph nodes: N0 or N1 only",
            "criterions": [
                {
                    "exact_snippets": "Clinical stage",
                    "criterion": "clinical stage",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N0 or N1 only"
                        }
                    ]
                },
                {
                    "exact_snippets": "Regional lymph nodes: N0 or N1 only",
                    "criterion": "regional lymph nodes",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N0 or N1 only"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage, Distant metastasis: M0 only",
            "criterions": [
                {
                    "exact_snippets": "Distant metastasis: M0 only",
                    "criterion": "distant metastasis",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "M0"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 40 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 40 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 40,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* prior malignancy within 5 years of lung nodule diagnosis",
            "criterions": [
                {
                    "exact_snippets": "prior malignancy within 5 years of lung nodule diagnosis",
                    "criterion": "prior malignancy",
                    "requirements": [
                        {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No nodule size available",
            "criterions": [
                {
                    "exact_snippets": "No nodule size available",
                    "criterion": "nodule size",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No pathology data available for those with",
            "criterions": [
                {
                    "exact_snippets": "No pathology data available",
                    "criterion": "pathology data",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Current diagnosis of non-small cell lung cancer",
            "criterions": [
                {
                    "exact_snippets": "Current diagnosis of non-small cell lung cancer",
                    "criterion": "non-small cell lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1",
            "criterions": [
                {
                    "exact_snippets": "Clinical stage: Primary tumor ≥T3",
                    "criterion": "primary tumor stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "T"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Regional lymph nodes: ≥N2",
                    "criterion": "regional lymph nodes stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Distant metastasis: ≥M1",
                    "criterion": "distant metastasis stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "M"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)",
            "criterions": [
                {
                    "exact_snippets": "Pathology: benign - inflammatory (e.g. granulomatous, infectious)",
                    "criterion": "pathology",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "benign"
                        },
                        {
                            "requirement_type": "subtype",
                            "expected_value": [
                                "inflammatory",
                                "granulomatous",
                                "infectious"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "Pathology: benign - non-inflammatory (e.g. hamartoma)",
                    "criterion": "pathology",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "benign"
                        },
                        {
                            "requirement_type": "subtype",
                            "expected_value": "non-inflammatory"
                        }
                    ]
                }
            ]
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}