{
    "info": {
        "nct_id": "NCT01691976",
        "official_title": "Mild Cognitive Impairment in Men Following Androgen Deprivation Therapy for Prostate Cancer: a Longitudinal fMRI and qEEG Pilot Study.",
        "inclusion_criteria": "* Male patients between the ages 50 to 90 years beginning ADT with LHRHa or PATCH participants randomised to either LHRHa or transdermal oestrogen for either newly diagnosed advanced prostate cancer or previously treated with radical radiotherapy or surgery and now having a rising prostate specific antigen will be included in the study.\nHealthy volunteers allowed\nMust be MALE\nMust have minimum age of 50 Years\nMust have maximum age of 90 Years",
        "exclusion_criteria": "* Patients with a known history of dementia will be excluded as well as those patients who have received any prior hormone therapy for localised prostate cancer.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Male patients between the ages 50 to 90 years beginning ADT with LHRHa or PATCH participants randomised to either LHRHa or transdermal oestrogen for either newly diagnosed advanced prostate cancer or previously treated with radical radiotherapy or surgery and now having a rising prostate specific antigen will be included in the study.",
            "criterions": [
                {
                    "exact_snippets": "Male patients",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "male"
                        }
                    ]
                },
                {
                    "exact_snippets": "between the ages 50 to 90 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 50,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 90,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "beginning ADT",
                    "criterion": "ADT status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "beginning"
                        }
                    ]
                },
                {
                    "exact_snippets": "LHRHa or PATCH participants randomised to either LHRHa or transdermal oestrogen",
                    "criterion": "treatment type",
                    "requirements": [
                        {
                            "requirement_type": "options",
                            "expected_value": [
                                "LHRHa",
                                "transdermal oestrogen"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "newly diagnosed advanced prostate cancer",
                    "criterion": "prostate cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "newly diagnosed advanced"
                        }
                    ]
                },
                {
                    "exact_snippets": "previously treated with radical radiotherapy or surgery",
                    "criterion": "previous treatment",
                    "requirements": [
                        {
                            "requirement_type": "options",
                            "expected_value": [
                                "radical radiotherapy",
                                "surgery"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "now having a rising prostate specific antigen",
                    "criterion": "prostate specific antigen status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "rising"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be MALE",
            "criterions": [
                {
                    "exact_snippets": "Must be MALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": "male"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 50 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 50 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 90 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 90 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Patients with a known history of dementia will be excluded as well as those patients who have received any prior hormone therapy for localised prostate cancer.",
            "criterions": [
                {
                    "exact_snippets": "known history of dementia",
                    "criterion": "dementia",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "received any prior hormone therapy for localised prostate cancer",
                    "criterion": "prior hormone therapy for localised prostate cancer",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}