{
    "info": {
        "nct_id": "NCT01660776",
        "official_title": "BMS_PD-L1_onco : Assessment of the PD-L1 Protein as a Biomarker in Oncology and Hematology",
        "inclusion_criteria": "General inclusion criteria :\n\n* Age ≥ 18 years and ≤ 75 years,\n* Life expectancy more than 4 months\n* Signed informed consent obtained\n* Social security affiliation is mandatory\n* Non previously treated (even by corticotherapy),\n* HIV negative, HBs negative, HCV negative\n\nInclusion criteria for DLBCL patients :\n\n* A biopsy proven diagnosis of de novo DLBCL according to the current WHO criteria,\n* Immunohistochemistry for GCB/nonGC classification according to Hans' algorithm\n* Patients with advanced-stage disease defined as Ann Arbor stages III or IV, or stages I or II with bulky disease (>7cm)\n\nInclusion criteria for non-small cell lung cancer patients :\n\n* A biopsy proven diagnosis of de novo non-small cell lung cancer (all stages) according to the current WHO criteria\n\nInclusion criteria for Hodgkin's lymphoma patients :\n\n* A biopsy proven diagnosis of Hodgkin's lymphoma according to the current WHO criteria\n\nInclusion criteria for metastatic breast cancer or with lymph node involvement :\n\n* A biopsy proven diagnosis infiltrating lobular or ductal breast carcinoma\n* with lymph node involvement or metastasis\n\nInclusion criteria for patients with immune thrombocytopenia (ITP) :\n\n* Primary ITP was defined by the IWG as a platelet count less than 100 G/L in the absence of other causes or disorders that may be associated with thrombocytopenia.\n* Bone marrow examination excluding a central aetiology of thrombocytopenia\n\nInclusion criteria for healthy volunteers :\n\n- Inclusion criteria for blood donation according to the Etablissement Français du Sang (EFS) criteria\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "General non-inclusion criteria :\n\n* Age < 18 years et > 75 years,\n* Pregnant women,\n* Person legally involved in a case\n* No social security affiliation\n* Signed informed consent not obtained,\n* Preliminary treatment (even corticoid treatment).\n* HIV positive, HBs positive, HCV positive\n\nNon-inclusion criteria for DLBCL patients :\n\n* Lymphoma other than DLBCL,\n* Transformation of a low grade lymphoma to a high grade lymphoma (DLBCL),\n* Extranodal marginal zone lymphoma of MALT lymphoma,\n* Post-transplant lymphoproliferative disorders,\n* Lymphoblastic lymphoma,\n* Burkitt's lymphoma,\n* Carcinoma or history of carcinoma except in situ cervical carcinoma.\n\nNon-inclusion criteria for non-small cell lung cancer patients : None\n\nNon-inclusion criteria for Hodgkin patients :\n\n- Non Hodgkin's lymphoma\n\nNon-inclusion criteria for metastatic breast cancer or with lymph node involvement :\n\n* Carcinoma other than infiltrating lobular or ductal breast carcinoma\n* Chemotherapy in 30 days preceding the inclusion\n* Hormonotherapy in 7 days preceding the inclusion\n* Carcinoma or history of carcinoma except in situ cervical carcinoma.\n* Hemoglobin level < 10g/dl\n\nNon-inclusion criteria for patients with immune thrombocytopenia (ITP) :\n\n- Central aetiology of the thrombocytopenia\n\nNon-inclusion criteria for healthy volunteers :\n\n- Exclusion criteria for blood donation according to the Etablissement Français du Sang (EFS) criteria",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age ≥ 18 years and ≤ 75 years,",
            "criterions": [
                {
                    "exact_snippets": "Age ≥ 18 years and ≤ 75 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Life expectancy more than 4 months",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy more than 4 months",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Signed informed consent obtained",
            "criterions": [
                {
                    "exact_snippets": "Signed informed consent obtained",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Social security affiliation is mandatory",
            "criterions": [
                {
                    "exact_snippets": "Social security affiliation is mandatory",
                    "criterion": "social security affiliation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Non previously treated (even by corticotherapy),",
            "criterions": [
                {
                    "exact_snippets": "Non previously treated",
                    "criterion": "previous treatment",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* HIV negative, HBs negative, HCV negative",
            "criterions": [
                {
                    "exact_snippets": "HIV negative",
                    "criterion": "HIV status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    ]
                },
                {
                    "exact_snippets": "HBs negative",
                    "criterion": "Hepatitis B surface antigen status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    ]
                },
                {
                    "exact_snippets": "HCV negative",
                    "criterion": "Hepatitis C virus status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion criteria for DLBCL patients :",
            "criterions": [
                {
                    "exact_snippets": "DLBCL patients",
                    "criterion": "DLBCL diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A biopsy proven diagnosis of de novo DLBCL according to the current WHO criteria,",
            "criterions": [
                {
                    "exact_snippets": "biopsy proven diagnosis of de novo DLBCL",
                    "criterion": "de novo DLBCL diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method of diagnosis",
                            "expected_value": "biopsy proven"
                        }
                    ]
                },
                {
                    "exact_snippets": "according to the current WHO criteria",
                    "criterion": "diagnosis criteria",
                    "requirements": [
                        {
                            "requirement_type": "standard",
                            "expected_value": "current WHO criteria"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Immunohistochemistry for GCB/nonGC classification according to Hans' algorithm",
            "criterions": [
                {
                    "exact_snippets": "Immunohistochemistry for GCB/nonGC classification according to Hans' algorithm",
                    "criterion": "GCB/nonGC classification",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "Immunohistochemistry"
                        },
                        {
                            "requirement_type": "algorithm",
                            "expected_value": "Hans' algorithm"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients with advanced-stage disease defined as Ann Arbor stages III or IV, or stages I or II with bulky disease (>7cm)",
            "criterions": [
                {
                    "exact_snippets": "advanced-stage disease defined as Ann Arbor stages III or IV",
                    "criterion": "disease stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "stages I or II with bulky disease (>7cm)",
                    "criterion": "disease stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "I",
                                "II"
                            ]
                        },
                        {
                            "requirement_type": "bulky disease",
                            "expected_value": {
                                "operator": ">",
                                "value": 7,
                                "unit": "cm"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion criteria for non-small cell lung cancer patients :",
            "criterions": [
                {
                    "exact_snippets": "non-small cell lung cancer",
                    "criterion": "non-small cell lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A biopsy proven diagnosis of de novo non-small cell lung cancer (all stages) according to the current WHO criteria",
            "criterions": [
                {
                    "exact_snippets": "biopsy proven diagnosis",
                    "criterion": "diagnosis method",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "biopsy"
                        }
                    ]
                },
                {
                    "exact_snippets": "de novo non-small cell lung cancer",
                    "criterion": "cancer type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": "de novo non-small cell lung cancer"
                        }
                    ]
                },
                {
                    "exact_snippets": "all stages",
                    "criterion": "cancer stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "all stages"
                        }
                    ]
                },
                {
                    "exact_snippets": "according to the current WHO criteria",
                    "criterion": "diagnosis criteria",
                    "requirements": [
                        {
                            "requirement_type": "criteria",
                            "expected_value": "current WHO criteria"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion criteria for Hodgkin's lymphoma patients :",
            "criterions": [
                {
                    "exact_snippets": "Hodgkin's lymphoma patients",
                    "criterion": "Hodgkin's lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A biopsy proven diagnosis of Hodgkin's lymphoma according to the current WHO criteria",
            "criterions": [
                {
                    "exact_snippets": "A biopsy proven diagnosis of Hodgkin's lymphoma",
                    "criterion": "Hodgkin's lymphoma diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "biopsy proven"
                        }
                    ]
                },
                {
                    "exact_snippets": "according to the current WHO criteria",
                    "criterion": "diagnosis criteria",
                    "requirements": [
                        {
                            "requirement_type": "standard",
                            "expected_value": "current WHO criteria"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion criteria for metastatic breast cancer or with lymph node involvement :",
            "criterions": [
                {
                    "exact_snippets": "metastatic breast cancer",
                    "criterion": "breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "metastatic"
                        }
                    ]
                },
                {
                    "exact_snippets": "lymph node involvement",
                    "criterion": "lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A biopsy proven diagnosis infiltrating lobular or ductal breast carcinoma",
            "criterions": [
                {
                    "exact_snippets": "biopsy proven diagnosis",
                    "criterion": "diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "method",
                            "expected_value": "biopsy proven"
                        }
                    ]
                },
                {
                    "exact_snippets": "infiltrating lobular or ductal breast carcinoma",
                    "criterion": "breast carcinoma type",
                    "requirements": [
                        {
                            "requirement_type": "type",
                            "expected_value": [
                                "infiltrating lobular",
                                "ductal"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* with lymph node involvement or metastasis",
            "criterions": [
                {
                    "exact_snippets": "lymph node involvement",
                    "criterion": "lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "metastasis",
                    "criterion": "metastasis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion criteria for patients with immune thrombocytopenia (ITP) :",
            "criterions": [
                {
                    "exact_snippets": "patients with immune thrombocytopenia (ITP)",
                    "criterion": "immune thrombocytopenia (ITP)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Primary ITP was defined by the IWG as a platelet count less than 100 G/L in the absence of other causes or disorders that may be associated with thrombocytopenia.",
            "criterions": [
                {
                    "exact_snippets": "platelet count less than 100 G/L",
                    "criterion": "platelet count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 100,
                                "unit": "G/L"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "absence of other causes or disorders that may be associated with thrombocytopenia",
                    "criterion": "other causes or disorders associated with thrombocytopenia",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Bone marrow examination excluding a central aetiology of thrombocytopenia",
            "criterions": [
                {
                    "exact_snippets": "Bone marrow examination",
                    "criterion": "bone marrow examination",
                    "requirements": [
                        {
                            "requirement_type": "purpose",
                            "expected_value": "excluding a central aetiology of thrombocytopenia"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion criteria for healthy volunteers :",
            "criterions": [
                {
                    "exact_snippets": "healthy volunteers",
                    "criterion": "health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "- Inclusion criteria for blood donation according to the Etablissement Français du Sang (EFS) criteria",
            "criterions": [
                {
                    "exact_snippets": "Inclusion criteria for blood donation according to the Etablissement Français du Sang (EFS) criteria",
                    "criterion": "blood donation eligibility",
                    "requirements": [
                        {
                            "requirement_type": "guideline",
                            "expected_value": "Etablissement Français du Sang (EFS) criteria"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 75 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Age < 18 years et > 75 years,",
            "criterions": [
                {
                    "exact_snippets": "Age < 18 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "Age ... > 75 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 75,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnant women,",
            "criterions": [
                {
                    "exact_snippets": "Pregnant women",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Person legally involved in a case",
            "criterions": [
                {
                    "exact_snippets": "Person legally involved in a case",
                    "criterion": "legal involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No social security affiliation",
            "criterions": [
                {
                    "exact_snippets": "No social security affiliation",
                    "criterion": "social security affiliation",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Signed informed consent not obtained,",
            "criterions": [
                {
                    "exact_snippets": "Signed informed consent not obtained",
                    "criterion": "informed consent",
                    "requirements": [
                        {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Preliminary treatment (even corticoid treatment).",
            "criterions": [
                {
                    "exact_snippets": "Preliminary treatment (even corticoid treatment)",
                    "criterion": "preliminary treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* HIV positive, HBs positive, HCV positive",
            "criterions": [
                {
                    "exact_snippets": "HIV positive",
                    "criterion": "HIV status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    ]
                },
                {
                    "exact_snippets": "HBs positive",
                    "criterion": "HBs status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    ]
                },
                {
                    "exact_snippets": "HCV positive",
                    "criterion": "HCV status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Non-inclusion criteria for DLBCL patients :",
            "criterions": [
                {
                    "exact_snippets": "DLBCL patients",
                    "criterion": "DLBCL diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Lymphoma other than DLBCL,",
            "criterions": [
                {
                    "exact_snippets": "Lymphoma other than DLBCL",
                    "criterion": "lymphoma type",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": "DLBCL"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Transformation of a low grade lymphoma to a high grade lymphoma (DLBCL),",
            "criterions": [
                {
                    "exact_snippets": "Transformation of a low grade lymphoma to a high grade lymphoma (DLBCL)",
                    "criterion": "lymphoma transformation",
                    "requirements": [
                        {
                            "requirement_type": "transformation",
                            "expected_value": "low grade to high grade (DLBCL)"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Extranodal marginal zone lymphoma of MALT lymphoma,",
            "criterions": [
                {
                    "exact_snippets": "Extranodal marginal zone lymphoma of MALT lymphoma",
                    "criterion": "extranodal marginal zone lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "MALT lymphoma",
                    "criterion": "MALT lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Post-transplant lymphoproliferative disorders,",
            "criterions": [
                {
                    "exact_snippets": "Post-transplant lymphoproliferative disorders",
                    "criterion": "post-transplant lymphoproliferative disorders",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Lymphoblastic lymphoma,",
            "criterions": [
                {
                    "exact_snippets": "Lymphoblastic lymphoma",
                    "criterion": "lymphoblastic lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Burkitt's lymphoma,",
            "criterions": [
                {
                    "exact_snippets": "Burkitt's lymphoma",
                    "criterion": "Burkitt's lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Carcinoma or history of carcinoma except in situ cervical carcinoma.",
            "criterions": [
                {
                    "exact_snippets": "Carcinoma",
                    "criterion": "carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "history of carcinoma",
                    "criterion": "history of carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "in situ cervical carcinoma",
                    "criterion": "in situ cervical carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Non-inclusion criteria for Hodgkin patients :",
            "criterions": [
                {
                    "exact_snippets": "Hodgkin patients",
                    "criterion": "Hodgkin disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "- Non Hodgkin's lymphoma",
            "criterions": [
                {
                    "exact_snippets": "Non Hodgkin's lymphoma",
                    "criterion": "Non Hodgkin's lymphoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Non-inclusion criteria for metastatic breast cancer or with lymph node involvement :",
            "criterions": [
                {
                    "exact_snippets": "metastatic breast cancer",
                    "criterion": "metastatic breast cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "lymph node involvement",
                    "criterion": "lymph node involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Carcinoma other than infiltrating lobular or ductal breast carcinoma",
            "criterions": [
                {
                    "exact_snippets": "Carcinoma other than infiltrating lobular or ductal breast carcinoma",
                    "criterion": "carcinoma type",
                    "requirements": [
                        {
                            "requirement_type": "exclusion",
                            "expected_value": [
                                "infiltrating lobular breast carcinoma",
                                "ductal breast carcinoma"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Chemotherapy in 30 days preceding the inclusion",
            "criterions": [
                {
                    "exact_snippets": "Chemotherapy in 30 days preceding the inclusion",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": "<=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Hormonotherapy in 7 days preceding the inclusion",
            "criterions": [
                {
                    "exact_snippets": "Hormonotherapy in 7 days preceding the inclusion",
                    "criterion": "hormonotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "7 days preceding the inclusion"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Carcinoma or history of carcinoma except in situ cervical carcinoma.",
            "criterions": [
                {
                    "exact_snippets": "Carcinoma",
                    "criterion": "carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "history of carcinoma",
                    "criterion": "history of carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "in situ cervical carcinoma",
                    "criterion": "in situ cervical carcinoma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Hemoglobin level < 10g/dl",
            "criterions": [
                {
                    "exact_snippets": "Hemoglobin level < 10g/dl",
                    "criterion": "hemoglobin level",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 10,
                                "unit": "g/dl"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Non-inclusion criteria for patients with immune thrombocytopenia (ITP) :",
            "criterions": [
                {
                    "exact_snippets": "immune thrombocytopenia (ITP)",
                    "criterion": "immune thrombocytopenia (ITP)",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "- Central aetiology of the thrombocytopenia",
            "criterions": [
                {
                    "exact_snippets": "Central aetiology of the thrombocytopenia",
                    "criterion": "thrombocytopenia",
                    "requirements": [
                        {
                            "requirement_type": "aetiology",
                            "expected_value": "central"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Non-inclusion criteria for healthy volunteers :",
            "criterions": [
                {
                    "exact_snippets": "healthy volunteers",
                    "criterion": "health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "- Exclusion criteria for blood donation according to the Etablissement Français du Sang (EFS) criteria",
            "criterions": [
                {
                    "exact_snippets": "Exclusion criteria for blood donation",
                    "criterion": "blood donation eligibility",
                    "requirements": [
                        {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "according to the Etablissement Français du Sang (EFS) criteria",
                    "criterion": "EFS criteria",
                    "requirements": [
                        {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "General inclusion criteria :",
            "criterions": []
        }
    ],
    "failed_exclusion": [
        {
            "line": "General non-inclusion criteria :",
            "criterions": []
        },
        {
            "line": "Non-inclusion criteria for non-small cell lung cancer patients : None",
            "criterions": []
        }
    ],
    "failed_miscellaneous": []
}