{
    "info": {
        "nct_id": "NCT01309282",
        "official_title": "Portuguese Observational Re-Treatment Study of MabThera (PORTSMAB) - A Two-centre Observational Study in Sero-positive Rheumatoid Arthritis (RA) Patients Who Are Non-responders or Intolerant to a Single Tumor Necrosis Factor (TNF) Inhibitor",
        "inclusion_criteria": "* Adult patients, >/= 18 years of age\n* Rheumatoid arthritis positive for rheumatoid factor and/or anti-CCP\n* Non-responder or intolerant to single TNF-inhibitor therapy\n* Initiating treatment with MabThera/Rituxan\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Contra-indications to MabThera/Rituxan therapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Adult patients, >/= 18 years of age",
            "criterions": [
                {
                    "exact_snippets": "Adult patients, >/= 18 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Rheumatoid arthritis positive for rheumatoid factor and/or anti-CCP",
            "criterions": [
                {
                    "exact_snippets": "Rheumatoid arthritis positive for rheumatoid factor",
                    "criterion": "rheumatoid factor",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Rheumatoid arthritis positive for ... anti-CCP",
                    "criterion": "anti-CCP",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Non-responder or intolerant to single TNF-inhibitor therapy",
            "criterions": [
                {
                    "exact_snippets": "Non-responder ... to single TNF-inhibitor therapy",
                    "criterion": "response to TNF-inhibitor therapy",
                    "requirements": [
                        {
                            "requirement_type": "response",
                            "expected_value": "non-responder"
                        }
                    ]
                },
                {
                    "exact_snippets": "intolerant to single TNF-inhibitor therapy",
                    "criterion": "tolerance to TNF-inhibitor therapy",
                    "requirements": [
                        {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Initiating treatment with MabThera/Rituxan",
            "criterions": [
                {
                    "exact_snippets": "Initiating treatment with MabThera/Rituxan",
                    "criterion": "treatment initiation",
                    "requirements": [
                        {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "MabThera",
                                "Rituxan"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Contra-indications to MabThera/Rituxan therapy",
            "criterions": [
                {
                    "exact_snippets": "Contra-indications to MabThera/Rituxan therapy",
                    "criterion": "MabThera/Rituxan therapy",
                    "requirements": [
                        {
                            "requirement_type": "contra-indications",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}