{
    "info": {
        "nct_id": "NCT01262820",
        "official_title": "A Multi-Center Open Label Phase II Study of Pazopanib in Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer After Progression on First Line Therapy Containing Bevacizumab",
        "inclusion_criteria": "* Age 18 or older\n* Stage IIIB (with malignant pleural or pericardial effusion or supraclavicular lymph node involvement) or stage IV NSCLC\n* Evidence of progression while on bevacizumab\n* Patients treated for CNS metastases who are asymptomatic with no requirement for steroids for 2 weeks prior to first dose of study drug\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Prior malignancy\n* Clinically significant gastrointestinal abnormalities\n* Presence of uncontrolled infection or nonhealing wound, fracture, or ulcer\n* History of cardiovascular conditions within the past 6 months",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age 18 or older",
            "criterions": [
                {
                    "exact_snippets": "Age 18 or older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Stage IIIB (with malignant pleural or pericardial effusion or supraclavicular lymph node involvement) or stage IV NSCLC",
            "criterions": [
                {
                    "exact_snippets": "Stage IIIB (with malignant pleural or pericardial effusion or supraclavicular lymph node involvement)",
                    "criterion": "NSCLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IIIB"
                        },
                        {
                            "requirement_type": "complications",
                            "expected_value": [
                                "malignant pleural effusion",
                                "malignant pericardial effusion",
                                "supraclavicular lymph node involvement"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "stage IV NSCLC",
                    "criterion": "NSCLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Evidence of progression while on bevacizumab",
            "criterions": [
                {
                    "exact_snippets": "Evidence of progression while on bevacizumab",
                    "criterion": "progression on bevacizumab",
                    "requirements": [
                        {
                            "requirement_type": "evidence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patients treated for CNS metastases who are asymptomatic with no requirement for steroids for 2 weeks prior to first dose of study drug",
            "criterions": [
                {
                    "exact_snippets": "Patients treated for CNS metastases",
                    "criterion": "CNS metastases treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "asymptomatic",
                    "criterion": "symptoms",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "no requirement for steroids",
                    "criterion": "steroid requirement",
                    "requirements": [
                        {
                            "requirement_type": "requirement",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "2 weeks prior to first dose of study drug",
                    "criterion": "steroid-free duration",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Prior malignancy",
            "criterions": [
                {
                    "exact_snippets": "Prior malignancy",
                    "criterion": "prior malignancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinically significant gastrointestinal abnormalities",
            "criterions": [
                {
                    "exact_snippets": "Clinically significant gastrointestinal abnormalities",
                    "criterion": "gastrointestinal abnormalities",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Presence of uncontrolled infection or nonhealing wound, fracture, or ulcer",
            "criterions": [
                {
                    "exact_snippets": "Presence of uncontrolled infection",
                    "criterion": "infection",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Presence of ... nonhealing wound",
                    "criterion": "wound",
                    "requirements": [
                        {
                            "requirement_type": "healing",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Presence of ... fracture",
                    "criterion": "fracture",
                    "requirements": [
                        {
                            "requirement_type": "healing",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "Presence of ... ulcer",
                    "criterion": "ulcer",
                    "requirements": [
                        {
                            "requirement_type": "healing",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* History of cardiovascular conditions within the past 6 months",
            "criterions": [
                {
                    "exact_snippets": "History of cardiovascular conditions within the past 6 months",
                    "criterion": "cardiovascular conditions",
                    "requirements": [
                        {
                            "requirement_type": "history",
                            "expected_value": {
                                "operator": "<=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}