{
    "info": {
        "nct_id": "NCT01193491",
        "official_title": "A Phase 1 Open-Label, Dose Escalation Study Evaluating the Safety and Tolerability of IPI-493 in Patients Experiencing Advanced Hematologic Malignancies With Client Proteins of Hsp90",
        "inclusion_criteria": "* >/=18 years old\n* ECOG 0-1\n* confirmed hematological malignancy\n* refractory to available therapy or for which no therapy is available\n* adequate hepatic, renal function\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* active CNS malignancy\n* prolonged QT interval\n* significant GI/liver disease\n* other serious concurrent illness or medical condition",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* >/=18 years old",
            "criterions": [
                {
                    "exact_snippets": ">/=18 years old",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* ECOG 0-1",
            "criterions": [
                {
                    "exact_snippets": "ECOG 0-1",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* confirmed hematological malignancy",
            "criterions": [
                {
                    "exact_snippets": "confirmed hematological malignancy",
                    "criterion": "hematological malignancy",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* refractory to available therapy or for which no therapy is available",
            "criterions": [
                {
                    "exact_snippets": "refractory to available therapy",
                    "criterion": "refractory to therapy",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "refractory"
                        }
                    ]
                },
                {
                    "exact_snippets": "no therapy is available",
                    "criterion": "availability of therapy",
                    "requirements": [
                        {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* adequate hepatic, renal function",
            "criterions": [
                {
                    "exact_snippets": "adequate hepatic",
                    "criterion": "hepatic function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "adequate ... renal function",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* active CNS malignancy",
            "criterions": [
                {
                    "exact_snippets": "active CNS malignancy",
                    "criterion": "CNS malignancy",
                    "requirements": [
                        {
                            "requirement_type": "activity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* prolonged QT interval",
            "criterions": [
                {
                    "exact_snippets": "prolonged QT interval",
                    "criterion": "QT interval",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": "prolonged"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* significant GI/liver disease",
            "criterions": [
                {
                    "exact_snippets": "significant GI/liver disease",
                    "criterion": "GI/liver disease",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* other serious concurrent illness or medical condition",
            "criterions": [
                {
                    "exact_snippets": "serious concurrent illness",
                    "criterion": "serious concurrent illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "serious concurrent ... medical condition",
                    "criterion": "serious concurrent medical condition",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}