{
    "info": {
        "nct_id": "NCT00971191",
        "official_title": "A Presurgical Study To Evaluate Molecular Changes That Occur In Human Non-Small Cell Lung Cancer Tissue After Short Term Exposure To PF-00299804",
        "inclusion_criteria": "* Radiographs consistent with lung cancer for which resection is indicated upon histologic confirmation of non-small cell lung cancer.\n* Patient willing to take PF-00299804 for 5 to 11 days and provide blood and tissue specimens as required in the study.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Prior or concurrent systemic anticancer therapy for cancer (immunotherapy, hormonotherapy, biological therapy, or chemotherapy) less than one year from time of consent.\n* Prior or concurrent radiation therapy to tumor at site of planned resection.\n* Congestive heart failure (LVEF < 50%), uncontrolled hypertension, significant ventricular arrythmia.\n* Drugs that are highly dependent on CYP2D6 for metabolism, or are generally accepted to have a risk of causing Torsades de Pointes.\n* Prior or concurrent radiation therapy to tumor at site of planned resection.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Radiographs consistent with lung cancer for which resection is indicated upon histologic confirmation of non-small cell lung cancer.",
            "criterions": [
                {
                    "exact_snippets": "Radiographs consistent with lung cancer",
                    "criterion": "lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "consistency",
                            "expected_value": "radiographs"
                        }
                    ]
                },
                {
                    "exact_snippets": "resection is indicated",
                    "criterion": "resection",
                    "requirements": [
                        {
                            "requirement_type": "indication",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "histologic confirmation of non-small cell lung cancer",
                    "criterion": "non-small cell lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "histologic"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Patient willing to take PF-00299804 for 5 to 11 days and provide blood and tissue specimens as required in the study.",
            "criterions": [
                {
                    "exact_snippets": "Patient willing to take PF-00299804",
                    "criterion": "willingness to take PF-00299804",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "provide blood and tissue specimens",
                    "criterion": "provision of blood and tissue specimens",
                    "requirements": [
                        {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Prior or concurrent systemic anticancer therapy for cancer (immunotherapy, hormonotherapy, biological therapy, or chemotherapy) less than one year from time of consent.",
            "criterions": [
                {
                    "exact_snippets": "Prior or concurrent systemic anticancer therapy for cancer (immunotherapy, hormonotherapy, biological therapy, or chemotherapy)",
                    "criterion": "systemic anticancer therapy",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": "prior or concurrent"
                        },
                        {
                            "requirement_type": "types",
                            "expected_value": [
                                "immunotherapy",
                                "hormonotherapy",
                                "biological therapy",
                                "chemotherapy"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "less than one year from time of consent",
                    "criterion": "time since last systemic anticancer therapy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior or concurrent radiation therapy to tumor at site of planned resection.",
            "criterions": [
                {
                    "exact_snippets": "Prior or concurrent radiation therapy to tumor at site of planned resection.",
                    "criterion": "radiation therapy to tumor",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": [
                                "prior",
                                "concurrent"
                            ]
                        },
                        {
                            "requirement_type": "location",
                            "expected_value": "site of planned resection"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Congestive heart failure (LVEF < 50%), uncontrolled hypertension, significant ventricular arrythmia.",
            "criterions": [
                {
                    "exact_snippets": "Congestive heart failure (LVEF < 50%)",
                    "criterion": "congestive heart failure",
                    "requirements": [
                        {
                            "requirement_type": "LVEF",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "uncontrolled hypertension",
                    "criterion": "hypertension",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": "uncontrolled"
                        }
                    ]
                },
                {
                    "exact_snippets": "significant ventricular arrythmia",
                    "criterion": "ventricular arrythmia",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Drugs that are highly dependent on CYP2D6 for metabolism, or are generally accepted to have a risk of causing Torsades de Pointes.",
            "criterions": [
                {
                    "exact_snippets": "Drugs that are highly dependent on CYP2D6 for metabolism",
                    "criterion": "CYP2D6 metabolism dependency",
                    "requirements": [
                        {
                            "requirement_type": "dependency",
                            "expected_value": "high"
                        }
                    ]
                },
                {
                    "exact_snippets": "Drugs that ... have a risk of causing Torsades de Pointes",
                    "criterion": "risk of causing Torsades de Pointes",
                    "requirements": [
                        {
                            "requirement_type": "risk",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior or concurrent radiation therapy to tumor at site of planned resection.",
            "criterions": [
                {
                    "exact_snippets": "Prior or concurrent radiation therapy to tumor at site of planned resection.",
                    "criterion": "radiation therapy to tumor",
                    "requirements": [
                        {
                            "requirement_type": "timing",
                            "expected_value": [
                                "prior",
                                "concurrent"
                            ]
                        },
                        {
                            "requirement_type": "location",
                            "expected_value": "site of planned resection"
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}