{
    "info": {
        "nct_id": "NCT00858520",
        "official_title": "Serum, Plasma, DNA and Tissue Bank of Patients With Chronic Obstructive Pulmonary Disease, Lung Cancer and Smoking Controls.",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 25 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "Inclusion Criteria for smokers:\n\n* A smoking history of at least 15 pack years and age of 50 years or older\n* Complete pulmonary function on day of visit\n* Chest CT-scan within one year of enrollment\n* 4 weeks from exacerbation\n\nExclusion Criteria for smokers:\n\n* Less than 15 pack years\n* Younger than 50 year\n* Other pulmonary diseases interfering with CT or pulmonary function\n* Asthma\n\nInclusion Criteria for lung cancer patients:\n\n* new diagnosis of proven lung cancer\n* chest CT scan within 2 months of enrollment\n* Complete pulmonary function\n\nExclusion Criteria for lung cancer patients\n\n* not able to perform pulmonary function\n* Absence of histological diagnosis of lung cancer"
    },
    "inclusion_lines": [
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 25 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 25 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 25,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "line": "Inclusion Criteria for smokers:",
            "criterions": [
                {
                    "exact_snippets": "smokers",
                    "criterion": "smoking status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "smoker"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* A smoking history of at least 15 pack years and age of 50 years or older",
            "criterions": [
                {
                    "exact_snippets": "smoking history of at least 15 pack years",
                    "criterion": "smoking history",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 15,
                                "unit": "pack years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "age of 50 years or older",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Complete pulmonary function on day of visit",
            "criterions": [
                {
                    "exact_snippets": "Complete pulmonary function",
                    "criterion": "pulmonary function",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Chest CT-scan within one year of enrollment",
            "criterions": [
                {
                    "exact_snippets": "Chest CT-scan within one year of enrollment",
                    "criterion": "Chest CT-scan",
                    "requirements": [
                        {
                            "requirement_type": "timeframe",
                            "expected_value": "within one year of enrollment"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* 4 weeks from exacerbation",
            "criterions": [
                {
                    "exact_snippets": "4 weeks from exacerbation",
                    "criterion": "time since exacerbation",
                    "requirements": [
                        {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Exclusion Criteria for smokers:",
            "criterions": [
                {
                    "exact_snippets": "Exclusion Criteria for smokers",
                    "criterion": "smoking status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "non-smoker"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Less than 15 pack years",
            "criterions": [
                {
                    "exact_snippets": "Less than 15 pack years",
                    "criterion": "smoking history",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 15,
                                "unit": "pack years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Younger than 50 year",
            "criterions": [
                {
                    "exact_snippets": "Younger than 50 year",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 50,
                                "unit": "year"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Other pulmonary diseases interfering with CT or pulmonary function",
            "criterions": [
                {
                    "exact_snippets": "Other pulmonary diseases interfering with CT",
                    "criterion": "pulmonary diseases",
                    "requirements": [
                        {
                            "requirement_type": "interference with CT",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Other pulmonary diseases interfering with ... pulmonary function",
                    "criterion": "pulmonary diseases",
                    "requirements": [
                        {
                            "requirement_type": "interference with pulmonary function",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Asthma",
            "criterions": [
                {
                    "exact_snippets": "Asthma",
                    "criterion": "asthma",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Inclusion Criteria for lung cancer patients:",
            "criterions": [
                {
                    "exact_snippets": "lung cancer patients",
                    "criterion": "lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* new diagnosis of proven lung cancer",
            "criterions": [
                {
                    "exact_snippets": "new diagnosis of proven lung cancer",
                    "criterion": "lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "diagnosis",
                            "expected_value": "new"
                        },
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "proven"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* chest CT scan within 2 months of enrollment",
            "criterions": [
                {
                    "exact_snippets": "chest CT scan within 2 months of enrollment",
                    "criterion": "chest CT scan",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within 2 months of enrollment"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Complete pulmonary function",
            "criterions": [
                {
                    "exact_snippets": "Complete pulmonary function",
                    "criterion": "pulmonary function",
                    "requirements": [
                        {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Exclusion Criteria for lung cancer patients",
            "criterions": [
                {
                    "exact_snippets": "lung cancer",
                    "criterion": "lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* not able to perform pulmonary function",
            "criterions": [
                {
                    "exact_snippets": "not able to perform pulmonary function",
                    "criterion": "pulmonary function",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Absence of histological diagnosis of lung cancer",
            "criterions": [
                {
                    "exact_snippets": "Absence of histological diagnosis of lung cancer",
                    "criterion": "histological diagnosis of lung cancer",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}