{
    "info": {
        "nct_id": "NCT00520676",
        "official_title": "A Randomized Phase 3 Study Comparing Pemetrexed-Carboplatin With Docetaxel-Carboplatin as First-Line Treatment for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer",
        "inclusion_criteria": "* Patient with locally advanced or metastatic (Stage IIIB/IV) NCSLC with no prior chemotherapy for advanced disease or molecular target treatment\n* Easter Cooperative Oncology Group (ECOG) performance status 0 to 2\n* Estimated life expectancy of at least 8 weeks\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Known or suspected brain metastases\n* Concurrent administration of any other tumor therapy\n* Serious concomitant disorders\n* Pregnancy or breast feeding\n* Inability or unwillingness to take folic acid or vitamin B12 supplementation",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patient with locally advanced or metastatic (Stage IIIB/IV) NCSLC with no prior chemotherapy for advanced disease or molecular target treatment",
            "criterions": [
                {
                    "exact_snippets": "locally advanced or metastatic (Stage IIIB/IV) NCSLC",
                    "criterion": "NCSLC stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "Stage IIIB",
                                "Stage IV"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "no prior chemotherapy for advanced disease",
                    "criterion": "prior chemotherapy for advanced disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "no prior ... molecular target treatment",
                    "criterion": "prior molecular target treatment",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Easter Cooperative Oncology Group (ECOG) performance status 0 to 2",
            "criterions": [
                {
                    "exact_snippets": "Easter Cooperative Oncology Group (ECOG) performance status 0 to 2",
                    "criterion": "ECOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Estimated life expectancy of at least 8 weeks",
            "criterions": [
                {
                    "exact_snippets": "Estimated life expectancy of at least 8 weeks",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Known or suspected brain metastases",
            "criterions": [
                {
                    "exact_snippets": "Known or suspected brain metastases",
                    "criterion": "brain metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Concurrent administration of any other tumor therapy",
            "criterions": [
                {
                    "exact_snippets": "Concurrent administration of any other tumor therapy",
                    "criterion": "concurrent tumor therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Serious concomitant disorders",
            "criterions": [
                {
                    "exact_snippets": "Serious concomitant disorders",
                    "criterion": "concomitant disorders",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Pregnancy or breast feeding",
            "criterions": [
                {
                    "exact_snippets": "Pregnancy",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "breast feeding",
                    "criterion": "breast feeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inability or unwillingness to take folic acid or vitamin B12 supplementation",
            "criterions": [
                {
                    "exact_snippets": "Inability or unwillingness to take folic acid",
                    "criterion": "folic acid supplementation",
                    "requirements": [
                        {
                            "requirement_type": "ability or willingness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Inability or unwillingness to take ... vitamin B12 supplementation",
                    "criterion": "vitamin B12 supplementation",
                    "requirements": [
                        {
                            "requirement_type": "ability or willingness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}