{
    "info": {
        "nct_id": "NCT00378131",
        "official_title": "A 12-Week, Double-Blind, Randomized, Placebo-Controlled, Parallel Group Phase II Study Comparing the Safety, Tolerability and Beneficial Effects of Daily Doses of RC-1291 and Placebo in Patients With Cancer Anorexia/Cachexia",
        "inclusion_criteria": "* Community-dwelling patients greater than 18 years of age with incurable, histologically diagnosed cancer.\n* Involuntary loss of body weight greater than 5% within the past 6 months\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Presently hospitalized or in a nursing care facility.\n* Inability to increase food intake from secondary causes.\n* Liver disease\n* If female-pregnant, breast-feeding or of childbearing potential.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Community-dwelling patients greater than 18 years of age with incurable, histologically diagnosed cancer.",
            "criterions": [
                {
                    "exact_snippets": "Community-dwelling patients",
                    "criterion": "residence status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "community-dwelling"
                        }
                    ]
                },
                {
                    "exact_snippets": "greater than 18 years of age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "incurable, histologically diagnosed cancer",
                    "criterion": "cancer diagnosis",
                    "requirements": [
                        {
                            "requirement_type": "curability",
                            "expected_value": "incurable"
                        },
                        {
                            "requirement_type": "diagnosis method",
                            "expected_value": "histologically diagnosed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Involuntary loss of body weight greater than 5% within the past 6 months",
            "criterions": [
                {
                    "exact_snippets": "Involuntary loss of body weight greater than 5% within the past 6 months",
                    "criterion": "body weight loss",
                    "requirements": [
                        {
                            "requirement_type": "involuntary",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "percentage",
                            "expected_value": {
                                "operator": ">",
                                "value": 5,
                                "unit": "%"
                            }
                        },
                        {
                            "requirement_type": "time frame",
                            "expected_value": "within the past 6 months"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Presently hospitalized or in a nursing care facility.",
            "criterions": [
                {
                    "exact_snippets": "Presently hospitalized",
                    "criterion": "hospitalization status",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "in a nursing care facility",
                    "criterion": "nursing care facility residency",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Inability to increase food intake from secondary causes.",
            "criterions": [
                {
                    "exact_snippets": "Inability to increase food intake",
                    "criterion": "food intake",
                    "requirements": [
                        {
                            "requirement_type": "ability",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "secondary causes",
                    "criterion": "secondary causes",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Liver disease",
            "criterions": [
                {
                    "exact_snippets": "Liver disease",
                    "criterion": "liver disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* If female-pregnant, breast-feeding or of childbearing potential.",
            "criterions": [
                {
                    "exact_snippets": "female-pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "breast-feeding",
                    "criterion": "breastfeeding",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "female ... of childbearing potential",
                    "criterion": "childbearing potential",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}