{
    "info": {
        "nct_id": "NCT00091273",
        "official_title": "Evaluation of Safety and Immunogenicity of a Peptide Vaccine in Patients With Epithelial Ovarian or Primary Peritoneal Cancer",
        "inclusion_criteria": "Healthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed ovarian epithelial or primary peritoneal cancer\n* Completed primary therapy (surgery and chemotherapy for newly diagnosed disease) within the past 12 months and meets 1 of the following criteria:\n\n  * Clinical or radiographic evidence of disease\n  * Serologic evidence of disease\n  * Initial diagnosis of stage III or IV disease AND completed anticancer therapy within the past 12 months\n* At least 2 intact axillary and/or inguinal lymph node basins\n\n  * Prior lymph node biopsy allowed provided lymphoscintigraphy demonstrates intact drainage to a node in that basin\n* HLA-A1-, -A2-, or -A3-positive\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* 18 and over\n\nPerformance status\n\n* GOG 0-2\n\nLife expectancy\n\n* Not specified\n\nHematopoietic\n\n* Absolute neutrophil count > 1,500/mm^3\n* Hemoglobin > 8.0 g/dL OR\n* Hematocrit > 25%\n* Platelet count ≥ 80,000/mm^3\n\nHepatic\n\n* AST and ALT ≤ 2.5 times upper limit of normal\n* Hepatitis C negative\n\nRenal\n\n* Not specified\n\nCardiovascular\n\n* No New York Heart Association class III or IV heart disease\n\nImmunologic\n\n* HIV negative\n* No active infection requiring antibiotics\n* No prior or active autoimmune disorder requiring cytotoxic or immunosuppressive therapy\n* No prior autoimmune disorder with visceral involvement\n* No known or suspected allergy to any component of the study vaccine\n* The following immunologic conditions are allowed:\n\n  * Laboratory evidence of autoimmune disease (e.g., positive antinuclear antibody titer) that is asymptomatic\n  * Clinical evidence of vitiligo or other forms of depigmenting illness\n  * Mild arthritis requiring non-steroidal anti-inflammatory drugs\n\nOther\n\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* Weight ≥ 110 lbs\n* No uncontrolled diabetes, defined as hemoglobin A1C ≥ 7%\n* No active hyperthyroidism\n* No current or recent (within the past year) addiction to alcohol or drugs\n* No medical contraindication or other potential medical problem that would preclude study compliance\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* More than 2 weeks since prior and no concurrent allergy desensitization injections\n* More than 2 weeks since prior and no concurrent growth factors (e.g., epoetin alfa or pegfilgrastim)\n* More than 1 month since prior and no other concurrent immunotherapy\n* More than 2 weeks since prior and no other concurrent potential immunomodulating agents, including any of the following:\n\n  * Interferon\n  * Tumor necrosis factor\n  * Interleukins or other cytokines\n  * Biologic response modifiers\n  * Monoclonal antibodies\n* No prior vaccination with all of the study peptides relevant to the patient's HLA-type\n\nChemotherapy\n\n* See Disease Characteristics\n* More than 1 month since prior chemotherapy and recovered\n* No concurrent cytotoxic chemotherapy\n\nEndocrine therapy\n\n* More than 2 weeks since prior and no concurrent parenteral or oral corticosteroids (e.g., prednisone or albuterol)\n\n  * Topical corticosteroids allowed\n\nRadiotherapy\n\n* More than 1 month since prior radiotherapy and recovered\n\nSurgery\n\n* See Disease Characteristics\n* More than 1 month since prior surgery and recovered\n\nOther\n\n* More than 1 month since other prior treatment and recovered\n* More than 1 month since prior and no other concurrent investigational agents"
    },
    "inclusion_lines": [
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": "Must be FEMALE",
                    "criterion": "gender",
                    "requirements": [
                        {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "line": "DISEASE CHARACTERISTICS:",
            "criterions": [
                {
                    "exact_snippets": "DISEASE CHARACTERISTICS",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Histologically confirmed ovarian epithelial or primary peritoneal cancer",
            "criterions": [
                {
                    "exact_snippets": "Histologically confirmed ovarian epithelial",
                    "criterion": "ovarian epithelial cancer",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    ]
                },
                {
                    "exact_snippets": "Histologically confirmed ... primary peritoneal cancer",
                    "criterion": "primary peritoneal cancer",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Completed primary therapy (surgery and chemotherapy for newly diagnosed disease) within the past 12 months and meets 1 of the following criteria:",
            "criterions": [
                {
                    "exact_snippets": "Completed primary therapy (surgery and chemotherapy for newly diagnosed disease)",
                    "criterion": "primary therapy completion",
                    "requirements": [
                        {
                            "requirement_type": "completion",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "within the past 12 months",
                    "criterion": "time since primary therapy completion",
                    "requirements": [
                        {
                            "requirement_type": "time since completion",
                            "expected_value": {
                                "operator": "<=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical or radiographic evidence of disease",
            "criterions": [
                {
                    "exact_snippets": "Clinical or radiographic evidence of disease",
                    "criterion": "disease evidence",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Serologic evidence of disease",
            "criterions": [
                {
                    "exact_snippets": "Serologic evidence of disease",
                    "criterion": "serologic evidence of disease",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Initial diagnosis of stage III or IV disease AND completed anticancer therapy within the past 12 months",
            "criterions": [
                {
                    "exact_snippets": "Initial diagnosis of stage III or IV disease",
                    "criterion": "disease stage",
                    "requirements": [
                        {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    ]
                },
                {
                    "exact_snippets": "completed anticancer therapy within the past 12 months",
                    "criterion": "anticancer therapy completion",
                    "requirements": [
                        {
                            "requirement_type": "completion time",
                            "expected_value": {
                                "operator": "<=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* At least 2 intact axillary and/or inguinal lymph node basins",
            "criterions": [
                {
                    "exact_snippets": "At least 2 intact axillary and/or inguinal lymph node basins",
                    "criterion": "intact axillary and/or inguinal lymph node basins",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Prior lymph node biopsy allowed provided lymphoscintigraphy demonstrates intact drainage to a node in that basin",
            "criterions": [
                {
                    "exact_snippets": "Prior lymph node biopsy allowed",
                    "criterion": "prior lymph node biopsy",
                    "requirements": [
                        {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "lymphoscintigraphy demonstrates intact drainage to a node in that basin",
                    "criterion": "lymphoscintigraphy",
                    "requirements": [
                        {
                            "requirement_type": "drainage",
                            "expected_value": "intact"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* HLA-A1-, -A2-, or -A3-positive",
            "criterions": [
                {
                    "exact_snippets": "HLA-A1-, -A2-, or -A3-positive",
                    "criterion": "HLA type",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": [
                                "HLA-A1",
                                "HLA-A2",
                                "HLA-A3"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "Age",
            "criterions": [
                {
                    "exact_snippets": "Age",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* 18 and over",
            "criterions": [
                {
                    "exact_snippets": "18 and over",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Performance status",
            "criterions": [
                {
                    "exact_snippets": "Performance status",
                    "criterion": "performance status",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* GOG 0-2",
            "criterions": [
                {
                    "exact_snippets": "GOG 0-2",
                    "criterion": "GOG performance status",
                    "requirements": [
                        {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Life expectancy",
            "criterions": [
                {
                    "exact_snippets": "Life expectancy",
                    "criterion": "life expectancy",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Hematopoietic",
            "criterions": [
                {
                    "exact_snippets": "Hematopoietic",
                    "criterion": "hematopoietic system",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Absolute neutrophil count > 1,500/mm^3",
            "criterions": [
                {
                    "exact_snippets": "Absolute neutrophil count > 1,500/mm^3",
                    "criterion": "absolute neutrophil count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Hemoglobin > 8.0 g/dL OR",
            "criterions": [
                {
                    "exact_snippets": "Hemoglobin > 8.0 g/dL",
                    "criterion": "hemoglobin level",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 8.0,
                                "unit": "g/dL"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Hematocrit > 25%",
            "criterions": [
                {
                    "exact_snippets": "Hematocrit > 25%",
                    "criterion": "hematocrit",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Platelet count ≥ 80,000/mm^3",
            "criterions": [
                {
                    "exact_snippets": "Platelet count ≥ 80,000/mm^3",
                    "criterion": "platelet count",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 80000,
                                "unit": "mm^3"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Hepatic",
            "criterions": [
                {
                    "exact_snippets": "Hepatic",
                    "criterion": "hepatic function",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* AST and ALT ≤ 2.5 times upper limit of normal",
            "criterions": [
                {
                    "exact_snippets": "AST and ALT ≤ 2.5 times upper limit of normal",
                    "criterion": "AST",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "times upper limit of normal"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "AST and ALT ≤ 2.5 times upper limit of normal",
                    "criterion": "ALT",
                    "requirements": [
                        {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "times upper limit of normal"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Hepatitis C negative",
            "criterions": [
                {
                    "exact_snippets": "Hepatitis C negative",
                    "criterion": "Hepatitis C",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Renal",
            "criterions": [
                {
                    "exact_snippets": "Renal",
                    "criterion": "renal function",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Cardiovascular",
            "criterions": [
                {
                    "exact_snippets": "Cardiovascular",
                    "criterion": "cardiovascular condition",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No New York Heart Association class III or IV heart disease",
            "criterions": [
                {
                    "exact_snippets": "No New York Heart Association class III or IV heart disease",
                    "criterion": "New York Heart Association heart disease class",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "!=",
                                "value": 3,
                                "unit": "class"
                            }
                        },
                        {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "!=",
                                "value": 4,
                                "unit": "class"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Immunologic",
            "criterions": [
                {
                    "exact_snippets": "Immunologic",
                    "criterion": "immunologic status",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "immunologic"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* HIV negative",
            "criterions": [
                {
                    "exact_snippets": "HIV negative",
                    "criterion": "HIV status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No active infection requiring antibiotics",
            "criterions": [
                {
                    "exact_snippets": "No active infection requiring antibiotics",
                    "criterion": "active infection",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No active infection requiring antibiotics",
                    "criterion": "antibiotics requirement",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No prior or active autoimmune disorder requiring cytotoxic or immunosuppressive therapy",
            "criterions": [
                {
                    "exact_snippets": "No prior or active autoimmune disorder",
                    "criterion": "autoimmune disorder",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "requiring cytotoxic or immunosuppressive therapy",
                    "criterion": "autoimmune disorder treatment",
                    "requirements": [
                        {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "cytotoxic",
                                "immunosuppressive"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No prior autoimmune disorder with visceral involvement",
            "criterions": [
                {
                    "exact_snippets": "No prior autoimmune disorder with visceral involvement",
                    "criterion": "autoimmune disorder with visceral involvement",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No known or suspected allergy to any component of the study vaccine",
            "criterions": [
                {
                    "exact_snippets": "No known or suspected allergy to any component of the study vaccine",
                    "criterion": "allergy to study vaccine components",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* The following immunologic conditions are allowed:",
            "criterions": [
                {
                    "exact_snippets": "immunologic conditions",
                    "criterion": "immunologic conditions",
                    "requirements": [
                        {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Laboratory evidence of autoimmune disease (e.g., positive antinuclear antibody titer) that is asymptomatic",
            "criterions": [
                {
                    "exact_snippets": "Laboratory evidence of autoimmune disease",
                    "criterion": "autoimmune disease",
                    "requirements": [
                        {
                            "requirement_type": "evidence",
                            "expected_value": "laboratory"
                        }
                    ]
                },
                {
                    "exact_snippets": "positive antinuclear antibody titer",
                    "criterion": "antinuclear antibody titer",
                    "requirements": [
                        {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    ]
                },
                {
                    "exact_snippets": "asymptomatic",
                    "criterion": "autoimmune disease",
                    "requirements": [
                        {
                            "requirement_type": "symptoms",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Clinical evidence of vitiligo or other forms of depigmenting illness",
            "criterions": [
                {
                    "exact_snippets": "Clinical evidence of vitiligo",
                    "criterion": "vitiligo",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other forms of depigmenting illness",
                    "criterion": "depigmenting illness",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Mild arthritis requiring non-steroidal anti-inflammatory drugs",
            "criterions": [
                {
                    "exact_snippets": "Mild arthritis",
                    "criterion": "arthritis",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "mild"
                        }
                    ]
                },
                {
                    "exact_snippets": "requiring non-steroidal anti-inflammatory drugs",
                    "criterion": "non-steroidal anti-inflammatory drugs",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Negative pregnancy test",
            "criterions": [
                {
                    "exact_snippets": "Negative pregnancy test",
                    "criterion": "pregnancy test",
                    "requirements": [
                        {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Fertile patients must use effective contraception",
            "criterions": [
                {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    ]
                },
                {
                    "exact_snippets": "must use effective contraception",
                    "criterion": "contraception use",
                    "requirements": [
                        {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Weight ≥ 110 lbs",
            "criterions": [
                {
                    "exact_snippets": "Weight ≥ 110 lbs",
                    "criterion": "weight",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 110,
                                "unit": "lbs"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No uncontrolled diabetes, defined as hemoglobin A1C ≥ 7%",
            "criterions": [
                {
                    "exact_snippets": "uncontrolled diabetes, defined as hemoglobin A1C ≥ 7%",
                    "criterion": "diabetes",
                    "requirements": [
                        {
                            "requirement_type": "control",
                            "expected_value": false
                        },
                        {
                            "requirement_type": "hemoglobin A1C",
                            "expected_value": {
                                "operator": ">=",
                                "value": 7,
                                "unit": "%"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No active hyperthyroidism",
            "criterions": [
                {
                    "exact_snippets": "No active hyperthyroidism",
                    "criterion": "hyperthyroidism",
                    "requirements": [
                        {
                            "requirement_type": "activity",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No current or recent (within the past year) addiction to alcohol or drugs",
            "criterions": [
                {
                    "exact_snippets": "No current or recent (within the past year) addiction to alcohol",
                    "criterion": "addiction to alcohol",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No current or recent (within the past year) addiction to ... drugs",
                    "criterion": "addiction to drugs",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No medical contraindication or other potential medical problem that would preclude study compliance",
            "criterions": [
                {
                    "exact_snippets": "No medical contraindication",
                    "criterion": "medical contraindication",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "other potential medical problem that would preclude study compliance",
                    "criterion": "potential medical problem",
                    "requirements": [
                        {
                            "requirement_type": "impact on study compliance",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "PRIOR CONCURRENT THERAPY:",
            "criterions": [
                {
                    "exact_snippets": "PRIOR CONCURRENT THERAPY",
                    "criterion": "prior concurrent therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Biologic therapy",
            "criterions": [
                {
                    "exact_snippets": "Biologic therapy",
                    "criterion": "biologic therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 2 weeks since prior and no concurrent allergy desensitization injections",
            "criterions": [
                {
                    "exact_snippets": "More than 2 weeks since prior ... allergy desensitization injections",
                    "criterion": "allergy desensitization injections",
                    "requirements": [
                        {
                            "requirement_type": "time since prior",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "weeks"
                            }
                        },
                        {
                            "requirement_type": "concurrent administration",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 2 weeks since prior and no concurrent growth factors (e.g., epoetin alfa or pegfilgrastim)",
            "criterions": [
                {
                    "exact_snippets": "More than 2 weeks since prior ... growth factors",
                    "criterion": "growth factors",
                    "requirements": [
                        {
                            "requirement_type": "time since prior",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "weeks"
                            }
                        },
                        {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 1 month since prior and no other concurrent immunotherapy",
            "criterions": [
                {
                    "exact_snippets": "More than 1 month since prior ... immunotherapy",
                    "criterion": "immunotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time since prior treatment",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        },
                        {
                            "requirement_type": "concurrent treatment",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 2 weeks since prior and no other concurrent potential immunomodulating agents, including any of the following:",
            "criterions": [
                {
                    "exact_snippets": "More than 2 weeks since prior ... concurrent potential immunomodulating agents",
                    "criterion": "immunomodulating agents",
                    "requirements": [
                        {
                            "requirement_type": "time since prior use",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "weeks"
                            }
                        },
                        {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Interferon",
            "criterions": [
                {
                    "exact_snippets": "Interferon",
                    "criterion": "interferon",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Tumor necrosis factor",
            "criterions": [
                {
                    "exact_snippets": "Tumor necrosis factor",
                    "criterion": "tumor necrosis factor",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Interleukins or other cytokines",
            "criterions": [
                {
                    "exact_snippets": "Interleukins",
                    "criterion": "interleukins",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "other cytokines",
                    "criterion": "cytokines",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Biologic response modifiers",
            "criterions": [
                {
                    "exact_snippets": "Biologic response modifiers",
                    "criterion": "biologic response modifiers",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Monoclonal antibodies",
            "criterions": [
                {
                    "exact_snippets": "Monoclonal antibodies",
                    "criterion": "monoclonal antibodies",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No prior vaccination with all of the study peptides relevant to the patient's HLA-type",
            "criterions": [
                {
                    "exact_snippets": "No prior vaccination with all of the study peptides relevant to the patient's HLA-type",
                    "criterion": "prior vaccination with study peptides",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "Chemotherapy",
                    "criterion": "chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* See Disease Characteristics",
            "criterions": [
                {
                    "exact_snippets": "Disease Characteristics",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "see details"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 1 month since prior chemotherapy and recovered",
            "criterions": [
                {
                    "exact_snippets": "More than 1 month since prior chemotherapy",
                    "criterion": "time since prior chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "recovered",
                    "criterion": "recovery from prior chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "recovery status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No concurrent cytotoxic chemotherapy",
            "criterions": [
                {
                    "exact_snippets": "No concurrent cytotoxic chemotherapy",
                    "criterion": "cytotoxic chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Endocrine therapy",
            "criterions": [
                {
                    "exact_snippets": "Endocrine therapy",
                    "criterion": "endocrine therapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 2 weeks since prior and no concurrent parenteral or oral corticosteroids (e.g., prednisone or albuterol)",
            "criterions": [
                {
                    "exact_snippets": "More than 2 weeks since prior ... parenteral or oral corticosteroids",
                    "criterion": "time since prior corticosteroids",
                    "requirements": [
                        {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "no concurrent parenteral or oral corticosteroids",
                    "criterion": "concurrent corticosteroids",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Topical corticosteroids allowed",
            "criterions": [
                {
                    "exact_snippets": "Topical corticosteroids allowed",
                    "criterion": "topical corticosteroids",
                    "requirements": [
                        {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Radiotherapy",
            "criterions": [
                {
                    "exact_snippets": "Radiotherapy",
                    "criterion": "radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 1 month since prior radiotherapy and recovered",
            "criterions": [
                {
                    "exact_snippets": "More than 1 month since prior radiotherapy",
                    "criterion": "time since prior radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "recovered",
                    "criterion": "recovery from prior radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "recovery status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "Surgery",
            "criterions": [
                {
                    "exact_snippets": "Surgery",
                    "criterion": "surgery",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* See Disease Characteristics",
            "criterions": [
                {
                    "exact_snippets": "Disease Characteristics",
                    "criterion": "disease characteristics",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": "see disease characteristics"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 1 month since prior surgery and recovered",
            "criterions": [
                {
                    "exact_snippets": "More than 1 month since prior surgery",
                    "criterion": "time since prior surgery",
                    "requirements": [
                        {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "recovered",
                    "criterion": "recovery from prior surgery",
                    "requirements": [
                        {
                            "requirement_type": "recovery status",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 1 month since other prior treatment and recovered",
            "criterions": [
                {
                    "exact_snippets": "More than 1 month since other prior treatment",
                    "criterion": "time since prior treatment",
                    "requirements": [
                        {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "recovered",
                    "criterion": "recovery from prior treatment",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* More than 1 month since prior and no other concurrent investigational agents",
            "criterions": [
                {
                    "exact_snippets": "More than 1 month since prior ... investigational agents",
                    "criterion": "time since prior investigational agents",
                    "requirements": [
                        {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    ]
                },
                {
                    "exact_snippets": "no other concurrent investigational agents",
                    "criterion": "concurrent investigational agents",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "line": "PATIENT CHARACTERISTICS:",
            "criterions": []
        },
        {
            "line": "* Not specified",
            "criterions": []
        },
        {
            "line": "* Not specified",
            "criterions": []
        },
        {
            "line": "Other",
            "criterions": []
        },
        {
            "line": "* Not pregnant or nursing",
            "criterions": [
                {
                    "exact_snippets": "Not pregnant",
                    "criterion": "pregnancy",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "not ... nursing",
                    "criterion": "nursing",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "Other",
            "criterions": []
        }
    ]
}