{
    "info": {
        "nct_id": "NCT03297125",
        "official_title": "Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using Advanced MRI",
        "inclusion_criteria": "* Newly diagnosed glioblastoma (GBM), World Health Organization (WHO) grade IV.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Optune compliance < 75%; they would be excluded from the final analyses.\n* History of craniectomy or significant skull defect (contraindication to Optune).\n* Active implantable medical device (e.g., deep brain stimulator (DBS), spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).\n* Karnofsky Performance Status (KPS) < 60.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Newly diagnosed glioblastoma (GBM), World Health Organization (WHO) grade IV.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Newly diagnosed glioblastoma (GBM)"
                        ],
                        "criterion": "glioblastoma",
                        "requirement_type": "diagnosis status",
                        "expected_value": "newly diagnosed"
                    },
                    {
                        "exact_snippets": [
                            "World Health Organization (WHO) grade IV"
                        ],
                        "criterion": "glioblastoma",
                        "requirement_type": "grade",
                        "expected_value": "World Health Organization (WHO) grade IV"
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Newly diagnosed glioblastoma (GBM)"
                        ],
                        "criterion": "glioblastoma",
                        "requirement_type": "diagnosis status",
                        "expected_value": "newly diagnosed"
                    },
                    {
                        "exact_snippets": [
                            "World Health Organization (WHO) grade IV"
                        ],
                        "criterion": "glioblastoma",
                        "requirement_type": "grade",
                        "expected_value": "World Health Organization (WHO) grade IV"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "Healthy volunteers allowed"
                        ],
                        "criterion": "healthy volunteers",
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": [
                            "minimum age of 18 Years"
                        ],
                        "criterion": "age",
                        "requirement_type": "minimum",
                        "expected_value": {
                            "operator": ">=",
                            "value": 18
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Optune compliance < 75%; they would be excluded from the final analyses.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Optune compliance < 75%"
                        ],
                        "criterion": "Optune compliance",
                        "requirement_type": "quantity",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<",
                                    "value": 75
                                }
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Optune compliance < 75%"
                    ],
                    "criterion": "Optune compliance",
                    "requirement_type": "quantity",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 75
                            }
                        ]
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* History of craniectomy or significant skull defect (contraindication to Optune).",
                "criterions": [
                    {
                        "exact_snippets": [
                            "History of craniectomy"
                        ],
                        "criterion": "craniectomy",
                        "requirement_type": "history",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "significant skull defect"
                        ],
                        "criterion": "skull defect",
                        "requirement_type": "severity",
                        "expected_value": "significant"
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "History of craniectomy"
                        ],
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                        "requirement_type": "history",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "significant skull defect"
                        ],
                        "criterion": "skull defect",
                        "requirement_type": "severity",
                        "expected_value": "significant"
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active implantable medical device (e.g., deep brain stimulator (DBS), spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Active implantable medical device"
                        ],
                        "criterion": "implantable medical device",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "deep brain stimulator (DBS)"
                        ],
                        "criterion": "deep brain stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "spinal cord stimulator"
                        ],
                        "criterion": "spinal cord stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "pacemaker"
                        ],
                        "criterion": "pacemaker",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "defibrillator"
                        ],
                        "criterion": "defibrillator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "vagus nerve stimulator"
                        ],
                        "criterion": "vagus nerve stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "programmable shunt"
                        ],
                        "criterion": "programmable shunt",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": [
                            "Active implantable medical device"
                        ],
                        "criterion": "implantable medical device",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "deep brain stimulator (DBS)"
                        ],
                        "criterion": "deep brain stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "spinal cord stimulator"
                        ],
                        "criterion": "spinal cord stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "pacemaker"
                        ],
                        "criterion": "pacemaker",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "defibrillator"
                        ],
                        "criterion": "defibrillator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "vagus nerve stimulator"
                        ],
                        "criterion": "vagus nerve stimulator",
                        "requirement_type": "presence",
                        "expected_value": true
                    },
                    {
                        "exact_snippets": [
                            "programmable shunt"
                        ],
                        "criterion": "programmable shunt",
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky Performance Status (KPS) < 60.",
                "criterions": [
                    {
                        "exact_snippets": [
                            "Karnofsky Performance Status (KPS) < 60"
                        ],
                        "criterion": "Karnofsky Performance Status",
                        "requirement_type": "value",
                        "expected_value": {
                            "operator": "<",
                            "value": 60
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": [
                        "Karnofsky Performance Status (KPS) < 60"
                    ],
                    "criterion": "Karnofsky Performance Status",
                    "requirement_type": "value",
                    "expected_value": {
                        "operator": "<",
                        "value": 60
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}